System-on-Chip Considerations for Heterogeneous Integration of CMOS and Fluidic Bio-Interfaces

Datta-Chaudhuri, Timir; Smela, Elisabeth; Abshire, Pamela

doi:10.1109/tbcas.2016.2522402

Cited by 29 publications

(18 citation statements)

References 84 publications

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“…Datta‐Chaudhuri et al have extensively reviewed the challenges faced by SoCs associated with the design, packaging, and integration of systems that interface CMOS with biology and fluidics. These include electrochemical effects, nonstandard packaging, surface treatments, sterilization, microfabrication of surface structures, and microfluidic integration . They further discuss a number of approaches used for packaging CMOS dice in LOC systems .…”

Section: Packaging Compatibility Between Cmos and Microfluidicsmentioning

confidence: 99%

“…Technology has now advanced so much that there are fully integrated sample‐in‐results‐out chips for genetic analysis, sensors that can detect a handful of molecules, and many other similar systems . Complementary metal oxide semiconductor (CMOS) integrated LOC systems can be developed using CMOS technologies as sensors, signal conditioners, data processing circuitry, actuators, and wireless communication capabilities . CMOS is a set of microfabrication and nanofabrication processes, which is used to manufacture semiconductor chips present inside computer, smartphone, or any electronic gadgets.…”

Section: Introductionmentioning

confidence: 99%

“…CMOS plays a significant role in the realization of portable and versatile microfluidic platforms by integrating them with microscale sensors, interfaces, and actuators to form autonomous hybrid systems . Adding interface electronics to the same CMOS chip as sensors, actuators, data processing, and communication capabilities creates a universal platform for LOC technologies.…”

Section: Introductionmentioning

confidence: 99%

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CMOS Enabled Microfluidic Systems for Healthcare Based Applications

et al. 2018

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additional parts, such as syringe pumps, control valves, and microscopes, which not only increase the complexity and cost of the system but also create a dependence of the system on a laboratorybased environment. Technology has now advanced so much that there are fully integrated sample-in-results-out chips for genetic analysis, [8] sensors that can detect a handful of molecules, and many other similar systems. [9] Complementary metal oxide semiconductor (CMOS) integrated LOC systems can be developed using CMOS technologies as sensors, signal conditioners, data processing circuitry, actuators, and wireless communication capabilities. [10][11][12][13][14][15][16][17] CMOS is a set of microfabrication and nanofabrication processes, which is used to manufacture semiconductor chips present inside computer, smartphone, or any electronic gadgets. Consequently, these chips are referred to as CMOS enabled or CMOS based chips. CMOS based chips can act as a processor, memory, and digital logic circuitry for data management. In this review, we will discuss how CMOS based devices have enabled both management of data from microfluidic devices as well as sensors and actuators to help complement the functionality of LOC devices. CMOS logics are simple to make, and consume little to no current in idle state. With the advancements in Moore's law we have seen the size of CMOS devices getting smaller and smaller allowing for more functionality to fit in a smaller area. [18] CMOS plays a significant role in the realization of portable and versatile microfluidic platforms by integrating them with microscale sensors, interfaces, and actuators to form autonomous hybrid systems. [10,12,16] Adding interface electronics to the same CMOS chip as sensors, actuators, data processing, and communication capabilities creates a universal platform for LOC technologies. Having signal amplification and noise removal right at the sensor interface without any signal loss makes the device output more accurate and sensitive, and also removes parasitic and mismatch errors. [1] By using CMOScompatible processes, it is possible to interface directly with the readout circuitry to form an integrated circuit system on a single chip. Signal acquisition from a large array of sensors to a single system requires a complex integration scheme, but CMOS microfabrication processes enable the integration of analogue multiplexers with biosensors on small dice. [19] CMOS also has the capability to actuate pumps and valves in microfluidic devices or to directly influence the fluid itself using electric With the increased global population, it is more important than ever to expand accessibility to affordable personalized healthcare. In this context, a seamless integration of microfluidic technology for bioanalysis and drug delivery and complementary metal oxide semiconductor (CMOS) technology enabled data-management circuitry is critical. Therefore, here, the fundamentals, integration aspects, and applications of CMOS-enabled microfluidic systems for affordable persona...

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Section: Packaging Compatibility Between Cmos and Microfluidicsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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CMOS Enabled Microfluidic Systems for Healthcare Based Applications

et al. 2018

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“…Furthermore, an IC can be used to recognize spikes in hardware, when and where they occur on the chip surface, and report this information off-chip using just a few wires for subsequent pattern recognition [25,26]. However, the integration of living cells with commercial CMOS technology had significant, unique challenges that had to be overcome for this demonstration, including packaging [27], circuit design, and other issues [28,29]. In this work we apply this technology development to olfaction, integrating a perfusion system and adapting mammalian cell culture and surface treatments to the culture of salamander olfactory sensory neurons on the surface of the chip.…”

Section: Introductionmentioning

confidence: 99%

Olfaction on a chip

Datta-Chaudhuri

Araneda

Abshire

et al. 2016

Sensors and Actuators B: Chemical

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On-chip sensing of physical signals is now relatively straightforward, with on-chip tilt sensors and cell phone cameras now ubiquitous, but sensing of odorants has proven to be far more challenging. A general purpose, mobile electronic nose would address pressing needs in security and food safety. We demonstrate here an approach that combines living olfactory sensory neurons (OSNs) with integrated circuitry. The hybrid bio-electronic chip harnesses the as-yet unparalleled capabilities of olfactory sensory neurons-in variety, selectivity, and ability to function in the real world-and takes advantage of modern silicon chip technology for detecting and processing electrical signals. OSNs were cultured directly over an array of electrodes on the surface of a custom integrated circuit so that the signals, a series of "spikes" upon odorant binding, could be locally detected and processed. Consistent and selective responses to specific odorants were recorded from individual neurons.

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“…Bioelectronic medicine continues to benefit from improved technology for neural modulation generated by the multidisciplinary team work of material scientists, electrical engineers, mechanical engineers, neuroscientists and colleagues from other disciplines (Cogan, 2008;Datta-Chaudhuri et al, 2016;Negi et al, 2010;Olafsdottir et al, 2018). The latest advances in flexible electrodes and other components for neuromodulation of peripheral nerves were outlined in Bioelectronic Medicine by Giagka and Serdijn (Giagka & Serdijn, 2018).…”

mentioning

confidence: 99%