Bioelectronic medicine: updates, challenges and paths forward

Pavlov, Valentin A.; Tracey, Kevin J.

doi:10.1186/s42234-019-0018-y

Cited by 48 publications

(44 citation statements)

References 43 publications

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“…A class of therapies that has gained considerable interest in recent years is bioelectronic medicine, which targets autonomic nerves to detect and alter neural activity for restoring autonomic functions [14][15][16] . The variety of bioelectronic medicine applications that target the vagus nerve have led to clinical trials on vagus nerve stimulation (VNS) for patients with epilepsy 17 , stroke 18 , depression 19 , rheumatoid arthritis 20 , obesity 21 , and type-2 diabetes 22 , among others.…”

Section: Introductionmentioning

confidence: 99%

Multi-channel intraneural vagus nerve recordings with a novel high-density carbon fiber microelectrode array

Jiman

Ratze

Welle

et al. 2020

Preprint

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25Autonomic nerves convey essential neural signals that regulate vital body functions. Recording 26 clearly distinctive physiological neural signals from autonomic nerves will help develop new 27 treatments for restoring regulatory functions. However, this is very challenging due to the small 28 nature of autonomic nerves and the low-amplitude signals from their small axons. We developed 29 a multi-channel, high-density, intraneural carbon fiber microelectrode array (CFMA) with ultra-30 small electrodes (8-9 µm in diameter, 150-250 µm in length) for recording physiological action 31 potentials from small autonomic nerves. In this study, we inserted CFMA with up to 16 32 recording carbon fibers in the cervical vagus nerve of 22 isoflurane-anesthetized rats. We 33 recorded action potentials with peak-to-peak amplitudes of 15.1-91.7 µV and signal-to-noise 34 ratios of 2.0-8.3 on multiple carbon fibers per experiment, determined conduction velocities of 35 some vagal signals in the afferent (0.7-1.0 m/sec) and efferent (0.7-8.8 m/sec) directions, and 36 monitored firing rate changes in breathing and blood glucose modulated conditions. Overall, 37 these experiments demonstrated that CFMAs are a novel interface for in-vivo intraneural action 38 potential recordings from autonomic nerves. This work is a milestone towards the 39 comprehensive understanding of physiological neural signaling and the development of 40 innovative treatment modalities for restoring vital functions controlled by autonomic nerves. 41 42

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Section: Introductionmentioning

confidence: 99%

Multi-channel intraneural vagus nerve recordings with a novel high-density carbon fiber microelectrode array

Jiman

Ratze

Welle

et al. 2020

Preprint

View full text Add to dashboard Cite

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“…In addition to the vagus nerve, studies on the regulatory role of other peripheral and CNS circuitries and the therapeutic usage of their modulation are considerably adding to progress in bioelectronic medicine ( Fig. 3; Talbot et al 2015;Guduru et al 2018;Güemes and Georgiou 2018;Jiman et al 2018;Kibleur and David 2018;Kovatchev 2018;Zhang et al 2018;Pavlov and Tracey 2019). These studies use methodological advances in material science, bioengineering, neuroscience, data analytics, computer modeling and mathematics, immunology, molecular biology, and other disciplines ( Fig.…”

Section: Bioelectronic Medicine: An Expanding Fieldmentioning

confidence: 99%

“…These studies use methodological advances in material science, bioengineering, neuroscience, data analytics, computer modeling and mathematics, immunology, molecular biology, and other disciplines ( Fig. 3; Bettinger 2018; Giagka and Serdijn 2018;Guduru et al 2018;Kovatchev 2018;Qing et al 2018;Sanjuan-Alberte et al 2018;Silverman et al 2018;Pavlov and Tracey 2019). Applying multidisciplinary approaches has been instrumental in discovering new molecular mechanisms of CNS and peripheral neural regulation, and identifying new therapeutic targets (Fig.…”

Section: Bioelectronic Medicine: An Expanding Fieldmentioning

confidence: 99%

“…These studies ultimately led to conceptually new developments in disease management and treatment under the umbrella of bioelectronic medicine ( Fig. 1; Tracey 2014; Olofsson and Tracey 2017;Pavlov and Tracey 2019). Here, we outline key aspects of the studies stemming from the discovery of the immunomodulatory function of the vagus nerve and the inflammatory reflex and leading to current clinical translation in bioelectronic medicine.…”

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confidence: 99%

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Bioelectronic Medicine: From Preclinical Studies on the Inflammatory Reflex to New Approaches in Disease Diagnosis and Treatment

Pavlov

Chavan

Tracey

2019

Cold Spring Harb Perspect Med

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Bioelectronic medicine is an evolving field in which new insights into the regulatory role of the nervous system and new developments in bioelectronic technology result in novel approaches in disease diagnosis and treatment. Studies on the immunoregulatory function of the vagus nerve and the inflammatory reflex have a specific place in bioelectronic medicine. These studies recently led to clinical trials with bioelectronic vagus nerve stimulation in inflammatory diseases and other conditions. Here, we outline key findings from this preclinical and clinical research. We also point to other aspects and pillars of interdisciplinary research and technological developments in bioelectronic medicine.

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“…Some researchers and pharmaceutical companies are already taking this potential new class of treatments seriously and due to promising results, others are expected to follow. [19] Imagine a prescription from your doctor, not for tablets but for a tiny electrical device implanted on a nerve in your neck. The device will monitor and treat your condition -whether it is diabetes, asthma, hypertension or even cancer -by modulating electrical impulses.…”

Section: Bioelectronics Medicinesmentioning

confidence: 99%

Advanced technologies in the modern era for augmented patient health care and drug delivery

Dev

Khanra

Shah

2020

J. Drug Delivery Ther.

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The objective of the work is to recognize the recent advancements in the modern health care and drug delivery systems. The article describes few recent developments in technology like artificial intelligence, personalized medicines, customized medicines, 3D printing, bioelectronic devices and tele pharmacy, which have the potential to augment health care and drug delivery in coming times. Personalized medication ensures precise health care as per the individual genetic makeup of the patients. The 3D printing technology enables to deliver tailor made solutions to fulfil individual patient requirements. Bioelectronic medicines and devices are new technology where the patient wears a device and its electrical signal cures certain ailments. Tele pharmacy ensures that the technological advances of telecommunications are also passed on to the patient health care sector. Moreover, it can be said that all these modern developments ensure that the quality of life improves and there comes a better control on the health care costs. Keywords: artificial intelligence, personalized medicines, customized medicines, 3D printing, bioelectronic devices and tele pharmacy

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Bioelectronic medicine: updates, challenges and paths forward

Cited by 48 publications

References 43 publications

Multi-channel intraneural vagus nerve recordings with a novel high-density carbon fiber microelectrode array

Multi-channel intraneural vagus nerve recordings with a novel high-density carbon fiber microelectrode array

Bioelectronic Medicine: From Preclinical Studies on the Inflammatory Reflex to New Approaches in Disease Diagnosis and Treatment

Advanced technologies in the modern era for augmented patient health care and drug delivery

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