Advanced technologies in the modern era for augmented patient health care and drug delivery

Dev, Asish; Khanra, Soma; Shah, Nilay D.

doi:10.22270/jddt.v10i1.3838

Cited by 3 publications

(1 citation statement)

References 11 publications

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“…Bioelectronic medicine has an important advantage over other therapies, as it can employ electrical, magnetic, optical, and ultrasound technologies to deliver targeted, personalized therapy and eliminate the need for drug‐centered therapy. The long‐term objective is to improve clinical and economical outcomes 33–35 …”

Section: Introductionmentioning

confidence: 99%

An Open‐Label Pilot Study Investigating Noninvasive High‐Frequency Peripheral Nerve Fiber Stimulation in Chronic Pain

Hegarty

Bretherton

2021

Pain Practice

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Objective Providing sustained and effective treatment via the peripheral nervous system for the management of chronic pain is challenging. Application of noninvasive high‐frequency stimulation at or near the painful area may benefit those with chronic pain. This open‐label pilot survey examined the impact of this stimulation on pain intensity, activities of daily living, functional capacity, and medication consumption after 2 weeks of treatment. Methods Stimulation was administered at home using the summation of two high‐frequency sinusoidal alternating signals at 3858 and 3980 Hz delivered between two electrodes placed directly over one or two locations of pain. Individuals completed a survey after 2 weeks to assess pain, activities of daily living (ADL), pain medication consumption, quality of life (QoL), mood, sleep, functional outcomes, and satisfaction. Results 463 individuals (372 males; 91 females) retuned the completed survey after 2 weeks of treatment. Pain and ADL scores significantly improved at follow‐up compared with baseline (pain mean difference: 3.05; 95% confidence interval [CI]: 2.86, 3.24; ADL mean difference: 1.82; 95% CI: 1.60, 2.04). Corresponding improvements in QoL, sleep, mood, functional outcomes, and satisfaction were noted. On average, 8.00 ± 11.11 hours of pain relief were reported with 54% experiencing reductions in pain medication consumption. 98% would use the stimulation in the future. Conclusion Two weeks of noninvasive high‐frequency peripheral nerve fiber stimulation appeared to confer positive effects in individuals with chronic pain. Future research employing a control group/arm is needed to establish the long‐term impact of this bioelectric technique in specific pain cohorts.

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Section: Introductionmentioning

confidence: 99%

An Open‐Label Pilot Study Investigating Noninvasive High‐Frequency Peripheral Nerve Fiber Stimulation in Chronic Pain

Hegarty

Bretherton

2021

Pain Practice

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Personalized Patient Safety Management: Sensors and Real-Time Data Analysis

Uddin

Munni²

2021

Vision, Sensing and Analytics: Integrative Approaches

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Practical Application of 3D Printing for Pharmaceuticals in Hospitals and Pharmacies

et al. 2023

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Three-dimensional (3D) printing is an unrivaled technique that uses computer-aided design and programming to create 3D products by stacking materials on a substrate. Today, 3D printing technology is used in the whole drug development process, from preclinical research to clinical trials to frontline medical treatment. From 2009 to 2020, the number of research articles on 3D printing in healthcare applications surged from around 10 to 2000. Three-dimensional printing technology has been applied to several kinds of drug delivery systems, such as oral controlled release systems, micropills, microchips, implants, microneedles, rapid dissolving tablets, and multiphase release dosage forms. Compared with conventional manufacturing methods of pharmaceutical products, 3D printing has many advantages, including high production rates due to the flexible operating systems and high drug loading with the desired precision and accuracy for potent drugs administered in small doses. The cost of production via 3D printing can be decreased by reducing material wastage, and the process can be adapted to multiple classes of pharmaceutically active ingredients, including those with poor solubility. Although several studies have addressed the benefits of 3D printing technology, hospitals and pharmacies have only implemented this process for a small number of practical applications. This article discusses recent 3D printing applications in hospitals and pharmacies for medicinal preparation. The article also covers the potential future applications of 3D printing in pharmaceuticals.

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Advanced technologies in the modern era for augmented patient health care and drug delivery

Cited by 3 publications

References 11 publications

An Open‐Label Pilot Study Investigating Noninvasive High‐Frequency Peripheral Nerve Fiber Stimulation in Chronic Pain

An Open‐Label Pilot Study Investigating Noninvasive High‐Frequency Peripheral Nerve Fiber Stimulation in Chronic Pain

Personalized Patient Safety Management: Sensors and Real-Time Data Analysis

Practical Application of 3D Printing for Pharmaceuticals in Hospitals and Pharmacies

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