System-level Study on Synergism and Antagonism of Active Ingredients in Traditional Chinese Medicine by Using Molecular Imprinting Technology

Chen, Tengfei; Gu, Jiangyong; Zhang, Xinzhuang; Cao, Liang; Wang, Zhenzhong; Chen, Lirong; Xu, Xiaojie; Xiao, Wei

doi:10.1038/srep07159

Cited by 11 publications

(5 citation statements)

References 47 publications

(45 reference statements)

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“…This is not however a unique challenge and all “biological systems are extremely complex and have emergent properties that cannot explained, or even predicted, by studying their individual parts” (Van Regenmortel, 2004 ). Emergent properties have been demonstrated in the networks of biological signaling pathways (Bhalla and Iyengar, 1999 ); in system-level study of traditional Chinese medicine (Chen et al, 2014 ), and in microbial communities (Wintermute and Silver, 2010 ; Chiu et al, 2014 ). To adequately explain the biological complexity present in plants and their interactions with the environment, Lüttge ( 2012 ) and Bertolli et al ( 2014 ) emphasize that classic reductionist biology/chemistry is indeed insufficient.…”

Section: Terminology and Definitionsmentioning

confidence: 99%

Biostimulants in Plant Science: A Global Perspective

Yakhin

Lubyanov²,

Yakhin³

et al. 2017

Front. Plant Sci.

922

661

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This review presents a comprehensive and systematic study of the field of plant biostimulants and considers the fundamental and innovative principles underlying this technology. The elucidation of the biological basis of biostimulant function is a prerequisite for the development of science-based biostimulant industry and sound regulations governing these compounds. The task of defining the biological basis of biostimulants as a class of compounds, however, is made more complex by the diverse sources of biostimulants present in the market, which include bacteria, fungi, seaweeds, higher plants, animals and humate-containing raw materials, and the wide diversity of industrial processes utilized in their preparation. To distinguish biostimulants from the existing legislative product categories we propose the following definition of a biostimulant as “a formulated product of biological origin that improves plant productivity as a consequence of the novel or emergent properties of the complex of constituents, and not as a sole consequence of the presence of known essential plant nutrients, plant growth regulators, or plant protective compounds.” The definition provided here is important as it emphasizes the principle that biological function can be positively modulated through application of molecules, or mixtures of molecules, for which an explicit mode of action has not been defined. Given the difficulty in determining a “mode of action” for a biostimulant, and recognizing the need for the market in biostimulants to attain legitimacy, we suggest that the focus of biostimulant research and validation should be upon proof of efficacy and safety and the determination of a broad mechanism of action, without a requirement for the determination of a specific mode of action. While there is a clear commercial imperative to rationalize biostimulants as a discrete class of products, there is also a compelling biological case for the science-based development of, and experimentation with biostimulants in the expectation that this may lead to the identification of novel biological molecules and phenomenon, pathways and processes, that would not have been discovered if the category of biostimulants did not exist, or was not considered legitimate.

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Section: Terminology and Definitionsmentioning

confidence: 99%

Biostimulants in Plant Science: A Global Perspective

Yakhin

Lubyanov²,

Yakhin³

et al. 2017

Front. Plant Sci.

922

661

View full text Add to dashboard Cite

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“…30 Antagonistic effects are caused by the competitive binding of the same compound in the infusion in combination with the same target protein pathway. 37 The α-glucosidase enzyme is an enzyme that plays an important role in the breakdown of carbohydrates in human. It works by hydrolyzing carbohydrates, releasing glucose that causes the increasing of post prandial glucose in the blood.…”

Section: Discussionmentioning

confidence: 99%

In vitro Antioxidant Properties and α-Glucosidase Inhibition of Combined Leaf Infusions from Psidium guajava L., Syzygium polyanthum L., and Annona muricata L.

Rahayu¹,

Heng²,

Timotius³

2019

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develop into permanent cell dysfunction. 10-12 Superoxide radicals in DM cause various damage through multiple pathways, such as Advanced Glycation End Products (AGEs), polyol pathways, hexosamine pathways and Kinase C proteins. This widespread impairment eventually leads to complications of microvascular disease. 13,14 According to Glamočlija and Jevrić-Čaušević, 15 there are five main classes of oral pharmacological agents to treat type 2 diabetes: sulfonylureas, megglitinides, metformin (a biguanide), thiazolidinediones, and α-glucosidase inhibitors. α-Glucosidase anchored in ABSTRACT Introduction: Guava (P. guajava), bay (S. polyanthum), and soursop (A. muricata) known as natural medicine. Limited report is available on their antioxidant and α-glucosidase inhibitory activities of leaf infusion. The aims of this research were to compare the antioxidant and α-glucosidase inhibitory activities of leaf infusion from guava, bay, and either as individual or combined infusions, and to analyze the chemical composition of the leaf infusion. Methods: Air dried leaf powder of guava, bay and soursop were infused separately with boiled aquadest. The infusions were analyzed for their antioxidant activity against DPPH. The α-glucosidase inhibitory assay was conducted against α-glucosidase from Saccharomyces cerevisiae. Then the infusions scanned with UV-Vis spectroscopy and analyzed with LC-MS. The synergism activities of the combined infusion were measured. Results: Antioxidant activities of leaf infusions of guava and bay showed a comparable result IC 50 12.53 ± 0.55 and 10.76 ± 0.20 µg GAE/mL, but the infusion of soursop showed lower (IC 50 19.77 ± 0.35 µg GAE/mL) than BHT as positive control (11.6 ± 0.31 µg GAE/mL). If soursop infusion was not added, then the mixture of the guava and bay infusion showed an antioxidative synergistic effect. The α-glucosidase inhibitory activities of the guava, bay and soursop infusion (0.083 ± 0.01; 0.025 ± 0.007; 0.533 ± 0.039 µg GAE/mL, respectively) were stronger than acarbose (1285 ± 148 µg/mL). The α-glucosidase inhibitory activities of the combined infusions showed a synergistic effect. The main constituents of the guava infusion were identified tentatively as chrysin and caffeoylquinic acid, for the bay infusion it was caffeoylquinic, and for the soursop infusion it was luteolin. Conclusions: There is a significant synergism of antioxidant activity of Guava and Bay mixture. The combined infusion of Bay and Soursop or Guava and Soursop showed antagonistic effect.

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“…Moreover, to offer potential clients seamless healthcare experiences, telehealth, telemedicine and other technology-based health solutions should be effectively integrated Chinese medicine as a tourism recoverydrawcard in current TCM systems so potential clients can communicate with TCM doctors and access healthcare in a timely, cost-effective manner regardless of whether clients reside in China or elsewhere (Chen et al, 2014(Chen et al, , 2015Li and Su, 2008;Litscher, 2020). Advanced TCM-centred technologies could also alleviate physician burdensolutions such as robot-controlled acupuncture are already available (Lan and Litscher, 2019).…”

Section: Leverage Tcm As a Tool For Economic Recoverymentioning

confidence: 99%

Traditional Chinese medicine as a tourism recovery drawcard to boost China's inbound tourism after COVID-19

Wen

Wang

Goh

et al. 2021

APJML

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PurposeThis paper explores the role of traditional Chinese medicine (TCM) as a tourism recovery drawcard to boost China's inbound tourism after COVID-19.Design/methodology/approachThis paper employed a mixed method involving a cross-disciplinary literature review along with reflections from experts in TCM and health communication to inform tourism management. Specifically, this paper examines TCM and its potential benefits as a medical tourism drawcard to combat COVID-19. The selected literature focusses on the image and merits of TCM to frame how this medical philosophy can be used to position China as a tourist destination. Reflections on the use of TCM as a tourism marketing tool can guide promotional strategies from the Chinese government and destination managers during and after COVID-19.FindingsThe Chinese government, the tourism industry (e.g. destination managers), the media and tourists must focus on three aspects of the role of TCM: to provide medical benefits to travellers amid COVID-19 and beyond, elevate China as a destination for global medical tourists and be leveraged as a tool for economic recovery.Practical implicationsThe paper builds a tourism recovery framework for stakeholders to adopt tailored TCM communication strategies to boost its inbound tourism programme.Originality/valueThis paper is the first academic paper to review TCM comprehensively and critically in relation to China tourism and post-COVID-19 recovery measures.

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System-level Study on Synergism and Antagonism of Active Ingredients in Traditional Chinese Medicine by Using Molecular Imprinting Technology

Cited by 11 publications

References 47 publications

Biostimulants in Plant Science: A Global Perspective

Biostimulants in Plant Science: A Global Perspective

In vitro Antioxidant Properties and α-Glucosidase Inhibition of Combined Leaf Infusions from Psidium guajava L., Syzygium polyanthum L., and Annona muricata L.

Traditional Chinese medicine as a tourism recovery drawcard to boost China's inbound tourism after COVID-19

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