“…The histologic features of gastric syphilis are not specific for diagnosis. Our observation is consistent with previous reports that gastritis was infiltrated with dense mixed inflammatory cells, mainly composed of lymphocyte and plasmocyte [1,4,16]. According to IHC staining, most lymphocytes were B cells, and their amount was more than that of plasmocyte.…”
Gastric syphilis is an uncommon disease, presenting nonspecific clinical and histological features. We present a rare case of 17-year-old women who had 2-week abdominal pain and sought for medical help. The patient was diagnosed with gastric syphilis, concomitantly infected with Helicobacter pylori (HP) and human immunodeficiency virus (HIV). The coexistence of HP and Treponema pallidum (TP) in gastric tissue was proved by immunohistochemical (IHC) staining. Multiple infections made diagnosis difficult. Comprehensive analysis of clinical, endoscopic, serological, and histopathologic data can avoid missed diagnosis.
“…The histologic features of gastric syphilis are not specific for diagnosis. Our observation is consistent with previous reports that gastritis was infiltrated with dense mixed inflammatory cells, mainly composed of lymphocyte and plasmocyte [1,4,16]. According to IHC staining, most lymphocytes were B cells, and their amount was more than that of plasmocyte.…”
Gastric syphilis is an uncommon disease, presenting nonspecific clinical and histological features. We present a rare case of 17-year-old women who had 2-week abdominal pain and sought for medical help. The patient was diagnosed with gastric syphilis, concomitantly infected with Helicobacter pylori (HP) and human immunodeficiency virus (HIV). The coexistence of HP and Treponema pallidum (TP) in gastric tissue was proved by immunohistochemical (IHC) staining. Multiple infections made diagnosis difficult. Comprehensive analysis of clinical, endoscopic, serological, and histopathologic data can avoid missed diagnosis.
“…Syphilitic gastritis is one of the rare manifestations of syphilis. Our study showed that similar to H. pylori infection, Treponema dominated other microbiota with a relative abundance of 65% [29].…”
Helicobacter pylori (H. pylori) related chronic gastritis is a well-known major etiological factor for gastric cancer development. However, H. pylori-negative gastritis (HpN) is not well described. We aimed to examine gastric mucosal microbiota in HpN compared to H. pylori-positive gastritis (HpP) and H. pylori-negative non-gastritis group (control). Here, we studied 11 subjects with HpN, 40 with HpP and 24 controls. We performed endoscopy with six gastric biopsies. Comparison groups were defined based on strict histological criteria for the disease and H. pylori diagnosis. We used 16S rRNA gene amplicon sequencing to profile the gastric microbiota according to comparison groups. These results demonstrate that the HpP group had significantly lower bacterial richness by the operational taxonomic unit (OTU) counts, and Shannon and Simpson indices as compared to HpN or controls. The linear discriminant analysis effect size analysis showed the enrichment of Firmicutes, Fusobacteria, Bacteroidetes and Actinobacteria at phylum level in the HpN group. In the age-adjusted multivariate analysis, Streptococcus sp. and Haemophilus parainfluenzae were at a significantly increased risk for HpN (odds ratio 18.9 and 12.3, respectively) based on abundance. Treponema sp. was uniquely found in HpN based on occurrence. In this paper, we conclude that Streptococcus sp., Haemophilus parainfluenzae and Treponema sp. are candidate pathogenic bacterial species for HpN. These results if confirmed may have important clinical implications.
“…Even though physical examinations were performed (revealing genital ulcers in 25% of patients), clinical suspicion of syphilis was only present in 7.8% of cases. However, only a concurrently positive serologic test (reported in 79% of patients) assisted in reaching the correct diagnosis, along with a complete medical (including sexual) history, an accurate physical examination, and a high clinical suspicion [46][47][48][49][50][51][52][53][54][55][56].…”
Despite the fact that gastric syphilis is considered rare, it is reported as a type of organic involvement that is present in a large proportion of secondary syphilis cases, even though gastritis presenting with symptoms is extremely rare. Clinical, radiological, and endoscopic findings are non-specific and frequently mimic the symptoms of gastric adenocarcinoma or lymphoma, making diagnosis difficult. Immunostaining is required for this diagnosis. We would like to emphasize the importance of being suspicious of GS when a gastric mass exhibits the histologic features of an inflammatory pseudotumor (IPT), as previously reported for nodal IPT caused by luetic infection. We described a 56-year-old man who presented to the oncology department with a 3-month history of anorexia, epigastric pain, nausea, vomiting, and weight loss, as well as an initial radiological and endoscopic suspicion of gastric adenocarcinoma, in which immune staining allowed us to diagnose GS. In addition, we conducted an updated scoping review of the scientific literature to show the clinical, laboratory, and therapeutic findings in GS patients over the last 65 years.
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