Syphilis and HIV-1 among parturient women in Salvador, Brazil: low prevalence of syphilis and high rate of loss to follow-up in HIV-infected women

Nóbrega, Isabella; Dantas, Paula Fernanda de Carvalho; Rocha, Priscila Lima; Rios, Isabela; Abraão, Marcos; Netto, Eduardo Martins; Brites, Carlos

doi:10.1016/j.bjid.2012.10.018

Cited by 10 publications

(10 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…We detected a 2.6 higher likelihood of syphilis in parturients with a late presentation to antenatal care. This confirms previous studies in Bahia, that found a close association between late/incomplete antenatal care engagement and syphilis . The association between syphilis and late presentation to antenatal care indicates existing barriers to access health services, lack of interest, or low awareness of the importance of early pregnancy screening and monitoring …”

Section: Acknowledgementssupporting

confidence: 90%

“…We detected a high prevalence (3.7%) of probable cases of congenital syphilis and a higher proportion of maternal syphilis with previous inadequate treatment than observed in previous published works . The rapid test was positive in 4.7% of parturients.…”

Section: Acknowledgementssupporting

confidence: 42%

“…Available data from Brazil show that the frequency of treatment for women′s sexual partners among congenital cases of syphilis varied between 11.5%, to 23.6% . In addition, the proportion of cases with missing information on treatment of the parturent′s sexual partners was high (46.9%), as well as the lack of information on preventive and therapeutic measures for syphilis in medical records.…”

Section: Acknowledgementsmentioning

confidence: 99%

See 2 more Smart Citations

High prevalence of syphilis in parturient women and congenital syphilis cases in public maternities in Salvador‐Bahia, Brazil

Vargas

Amaral

Arriaga

et al. 2018

BJOG

View full text Add to dashboard Cite

Section: Acknowledgementssupporting

confidence: 90%

Section: Acknowledgementssupporting

confidence: 42%

Section: Acknowledgementsmentioning

confidence: 99%

See 1 more Smart Citation

High prevalence of syphilis in parturient women and congenital syphilis cases in public maternities in Salvador‐Bahia, Brazil

Vargas

Amaral

Arriaga

et al. 2018

BJOG

View full text Add to dashboard Cite

“…The consistent use of condoms during intercourse was low, and 20% of the surveyed women had contact with HIV-1-positive individuals. Although drugs were not used intravenously, this variable promotes other variables of risk, including unprotected sexual relations with anal intercourse, as previously shown in other studies [12, 13]. Even with the existence of a free treatment program widely distributed across the country, a large percentage of this population was not using ART, and even worse, nearly one third of this population had never used the treatment facilities.…”

Section: Discussionmentioning

confidence: 68%

Lower genetic variability of HIV-1 and antiretroviral drug resistance in pregnant women from the state of Pará, Brazil

et al. 2017

View full text Add to dashboard Cite

BackgroundThe present study aimed to describe the genetic diversity of HIV-1, as well as the resistance profile of the viruses identified in HIV-1 infected pregnant women under antiretroviral therapy in the state of Pará, Northern Brazil.MethodsBlood samples were collected from 45 HIV-1 infected pregnant to determine the virus subtypes according to the HIV-1 protease (PR) gene and part of the HIV-1 reverse transcriptase (RT) gene by sequencing the nucleotides of these regions. Drug resistance mutations and susceptibility to antiretroviral drugs were analyzed by the Stanford HIV Drug Resistance Database.ResultsOut of 45 samples, only 34 could be amplified for PR and 30 for RT. Regarding the PR gene, subtypes B (97.1%) and C (2.9%) were identified; for the RT gene, subtypes B (90.0%), F (6.7%), and C (3.3%) were detected. Resistance to protease inhibitors (PI) was identified in 5.8% of the pregnant, and mutations conferring resistance to nucleoside reverse transcriptase inhibitors were found in 3.3%, while mutations conferring resistance to non-nucleoside reverse transcriptase inhibitors were found in 3.3%.ConclusionsThese results showed a low frequency of strains resistant to antiretroviral drugs, the prevalence of subtypes B and F, and the persistent low transmission of subtype C in pregnant of the state of Pará, Brazil.

show abstract

“…Esse valor foi significativamente superior ao que foi obtido com estudos realizados na mesma região em anos anteriores, em que a prevalência encontrada não alcançou o valor de 1% (NÓBREGA, 2014). Isso corrobora a hipótese de que há uma subestimação (e, adicionalmente, uma subnotificação) do número de casos de sífilis em gestantes na população soteropolitana, levantada pelos estudos de vigilância epidemiológica, realizada até o momento.…”

Section: Discussionunclassified

Sífilis em Gestantes de Salvador: Análise da Soroprevalência e Possíveis Fatores para Transmissão Vertical

Duarte

Lima

2016

Iniciac cient Cesumar

View full text Add to dashboard Cite

RESUMO:A transmissão vertical da sífilis se mantém como um grande desafio para a saúde pública, demandando novas estratégias de vigilância epidemiológica. Apesar de as medidas de controle da sífilis materna e congênita estarem disponíveis no Brasil, existem dificuldades da rede em prover o diagnóstico laboratorial da infecção durante o pré-natal. O conhecimento da prevalência da doença funciona como um importante indicador da qualidade da assistência pré-natal, fornecida pelo Sistema Único de Saúde. O presente trabalho visa identificar a soroprevalência da sífilis em gestantes e recém-nascidos em Salvador, Bahia, por meio dos métodos sorológicos treponêmicos e não treponêmicos, e determinar possíveis fatores de risco socioeconômicos, associados à chance de se adquirir a infecção, por meio de análise estatística dos dados obtidos por um questionário. A soroprevalência encontrada foi de 4,07% (31 pacientes de 762 participantes), significativamente superior à relatada nos últimos boletins epidemiológicos. Os dados socioeconômicos não apresentaram valores estatisticamente significativos, mas descrevem hábitos de risco da população gestante de Salvador que demandam mais educação em saúde, a fim de se controlar a propagação da infecção. PALAVRAS-CHAVE:Imunologia; Sífilis Congênita; Soroepidemiologia. SYPHILIS IN PREGNANT WOMEN IN SALVADOR, BRAZIL: ANALYSIS OF SERUM PREVALENCE AND POSSIBLE FACTORS FOR VERTICAL TRANSMISSION ABSTRACT:The vertical transmission of syphilis is still a great challenge in public health and requires new strategies in epidemiological surveillance. In spite of the control in maternal syphilis, several difficulties exist to diagnose the infection in the laboratory during the pre-natal period. Prevalence of the disease is an important indicator for the pre-natal assistance quality provided by the Brazilian Health System. Current essay identifies the serum prevalence of syphilis in pregnant women and newly-born children in Salvador, Brazil, by treponemic and não-treponemic serological methods, and determines possible socio-economical risk factors associated to possibility in being infected by statistical data analyses provided by a questionnaire. Sero-prevalence reached 4.07% (31 patients in 762 participants), significantly higher than that reported in the latest Epidemiological Bulletins. Socio-economic data failed to provide significant statistical rates but describes risk habits of the pregnant population in Salvador, demanding more health information to control the spread of the disease. KEYWORDS: INTRODUÇÃOA sífilis é uma doença infecciosa de evolução geralmente crônica, causada pela bactéria Treponema pallidum. A transmissão pode ocorrer por meio do contato sexual (desenvolvendo a forma adquirida da infecção), por transfusão sanguínea e por transmissão vertical (infecção congênita), tendo destaque, nesse segundo caso, por ser a segunda doença com maiores taxas de transmissão durante o ciclo grávido-puerperal (BRASIL, 2006). É interessante ressaltar que, embora seja uma doença que ainda hoje ...

show abstract

Syphilis and HIV-1 among parturient women in Salvador, Brazil: low prevalence of syphilis and high rate of loss to follow-up in HIV-infected women

Cited by 10 publications

References 14 publications

High prevalence of syphilis in parturient women and congenital syphilis cases in public maternities in Salvador‐Bahia, Brazil

High prevalence of syphilis in parturient women and congenital syphilis cases in public maternities in Salvador‐Bahia, Brazil

Lower genetic variability of HIV-1 and antiretroviral drug resistance in pregnant women from the state of Pará, Brazil

Sífilis em Gestantes de Salvador: Análise da Soroprevalência e Possíveis Fatores para Transmissão Vertical

Contact Info

Product

Resources

About