Synthetic zeolites as a new tool for drug delivery

Abstract

Synthetic zeolites were studied in order to investigate their ability to encapsulate and to release drugs. In particular, a zeolite X and a zeolitic product obtained from a cocrystallization of zeolite X and zeolite A were examined. These materials were characterized by chemical analyses (ICP-AES), X-ray diffraction, nitrogen adsorption isotherm, scanning electron microscopy, laser diffraction, and infrared spectroscopy. Since ketoprofen was chosen as a model drug for the formulation of controlled-release dosage forms, it was encapsulated into these two types of synthetic zeolites by a soaking procedure. Drug-loaded matrices were then characterized for entrapped drug amount and thermogravimetric behavior. In both types of activated zeolites, the total amount of ketoprofen (800 mg) was encapsulated in 2 g of matrix. By using HPLC measurements, ketoprofen release studies were done at different pH conditions so as to mimick gastrointestinal fluids. The absence of release in acid conditions and a double phased release, at two different pH values (5 and 6.8), suggest that after activation these materials offer good potential for a modified release delivery system of ketoprofen.

Silver nanoparticles embedded in zeolite membranes: release of silver ions and mechanism of antibacterial action

“…Another study demonstrated the feasibility of zeolites as a vehicle for drug delivery by releasing ketoprofen under different physiological conditions. 30 We have shown that surface-modified zeolites can release paraquat under controlled conditions. 31 However, this study is the first to demonstrate that zeolite membranes can serve as supports, and we demonstrate this functionality using AgNP for antibacterial use.…”

Zeolite-based biomaterials for biomedical application: A review

“…Zeolites crystals are already popular materials as catalysts, adsorbents and ion exchangers, however, they are new materials in the field of drug reservoirs in the delivery of controlled drug [39][40][41] and new categories of biomedical materials. The large pores observed in the zeolite framework made easy the leisurely release of materials so that it can be accepted for medicine delivery implementation [42].…”

Synthesis and Characterization of Mesoporous NaX Zeolite from Kaolin Loading of Soursop Leaves Extract (Annona muricata Linn.)

“…Zeolite with various types is very potential in this case. X zeolite synthetic has been quite effective with no negative effect when encapsulated on ketopofren drug based on research of Rimoli et al (2007).…”