Synthetic Studies on Erythromycin Derivatives: Reactivity of the C12-21 Alkene

Chen, Weimin

doi:10.3390/11010121

Cited by 3 publications

(2 citation statements)

References 14 publications

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“…Currently, the largest tung oil producing country is China which produces about 80,000 tons of oil per year or supplies around 70%-80% of tung oil in the world market [2]. However, the current production of tung oil has not been able to meet the needs of the international market [3]. The trade value of Tung oil in the international market is estimated to increase to US$ 330 billion in 2025, from around US$ 270 billion in 2018.…”

Section: Introductionmentioning

confidence: 99%

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Gamma irradiation effects on seed germination, growth and morphological traits of kemiri sunan (Reutialis trisperma(Blanco) Airy Shaw)

Ajijah,

Tresniawati,

Izza

et al. 2023

E3S Web Conf.

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Kemiri Sunan is a biodiesel producing tree that has an ecological function as a reforestation plant since it can adapt to the marginal, dry and ex-mining land. It is necessary to increase the genetic diversity of kemiri sunan through mutation in order to support its breeding program. Dried seeds of Karmindo1 and M03 varieties were exposed to gamma sources with doses ranging from 50 to 1000 Gy to evaluate the effect of gamma irradiation on the germination and growth of kemiri sunan seeds. The percentage of germination, as well as physiological parameters of seedlings (shoot length and number of leaves) decreased with increasing irradiation doses. However, the two varieties showed a difference in sensitivity responses to gamma rays. The recommendation doses for the two varieties are 100 – 200 Gy and 50 – 100 Gy for Karmindo1 and M03 respectively. No morphological variation was found in seedlings except for one mutant with early branch formation. The development of this plant is important, not only as an alternative source of renewable energy, but also as one of the crops that can adapt to the threat of global climate change such as drought.

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Section: Introductionmentioning

confidence: 99%

“…The trade value of Tung oil in the international market is estimated to increase to US$ 330 billion in 2025, from around US$ 270 billion in 2018. Therefore, it is important to develop research on kemiri sunan as both biodiesel and tung oil producing plant [3].…”

Section: Introductionmentioning

confidence: 99%

Gamma irradiation effects on seed germination, growth and morphological traits of kemiri sunan (Reutialis trisperma(Blanco) Airy Shaw)

Ajijah,

Tresniawati,

Izza

et al. 2023

E3S Web Conf.

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Synthesis and antibacterial activity of C-12 pyrazolinyl spiro ketolides

Lan

Song

et al. 2010

European Journal of Medicinal Chemistry

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Structure-Activity Relationships and Mechanism of Action of Macrolides Derived from Erythromycin as Antibacterial Agents

Liang

Han

2013

CTMC

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Enormous efforts were focused on the 3-descladinosyl erythromycin derivatives which led to 3-keto (ketolides), 3-O-acyl (acylides), 3-O-carbamate (carbamolides), and 3-O-alkyl (alkylides) and cladinosyl-containing erythromycin derivatives such as 4"-O-acyl, 4"-O-carbamate, and 4"-O-alkyl derivatives as recently exemplified by macrolones (macrolide-quinolone hybrids). Ketolides acquire activity against MLSB-resistant pathogens via a featured arylalkyl extension suspended on the macrolide core, which interacts with a base pair formed by A752Ec and U2609Ec located in the nascent peptide release tunnel of the bacterial rRNA. A base pair formed by C2610Ec and G2505Ec probably is another novel binding site for 3-descladinosyl non-ketolides. It is believed that 4"-derived compounds perhaps interfere with the formation of polypeptide because the extension oriented into peptidyl transferase center (PTC) region. Although macrolones are hybrids of macrolides and quinolones, they do not have dual modes of action, and serve only as protein synthesis inhibitors.

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Synthetic Studies on Erythromycin Derivatives: Reactivity of the C12-21 Alkene

Cited by 3 publications

References 14 publications

Gamma irradiation effects on seed germination, growth and morphological traits of kemiri sunan (Reutialis trisperma(Blanco) Airy Shaw)

Gamma irradiation effects on seed germination, growth and morphological traits of kemiri sunan (Reutialis trisperma(Blanco) Airy Shaw)

Synthesis and antibacterial activity of C-12 pyrazolinyl spiro ketolides

Structure-Activity Relationships and Mechanism of Action of Macrolides Derived from Erythromycin as Antibacterial Agents

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