Synthesis and antibacterial activity of C-12 pyrazolinyl spiro ketolides

Hu, Lei; Lan, Ping; Song, Qiuling; Huang, Zhijian; Sun, Ping‐Hua; Zhuo, Chao; Wang, Ying; Xiao, Shunian; Chen, Weimin

doi:10.1016/j.ejmech.2010.09.060

Cited by 13 publications

(3 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Spiro compounds have been mainly used in insecticides, while there have been fewer reports of their application in herbicides, fungicides, antiviral agents, and as plant growth regulators (Figure , right). Medical reviews of spiro compounds have been widely documented, − but, to our knowledge, their use within pesticides has not been reviewed. This review summarizes the application of spiro compounds in pesticides with the aim of assisting further research in related fields.…”

Section: Introductionmentioning

confidence: 99%

Spiro Derivatives in the Discovery of New Pesticides: A Research Review

Dai

Zhang

et al. 2022

J. Agric. Food Chem.

View full text Add to dashboard Cite

Spiro compounds are biologically active organic compounds with unique structures, found in a wide variety of natural products and drugs. They do not readily lead to drug resistance due to their unique mechanisms of action and have, therefore, attracted considerable attention regarding pesticide development. Analyzing structure−activity relationships (SARs) and summarizing the characteristics of spiro compounds with high activity are crucial steps in the design and development of new pesticides. This review mainly summarizes spiro compounds with insecticidal, bactericidal, fungicidal, herbicidal, antiviral, and plant growth regulating functions to provide insight for the creation of new spiro compound pesticides.

show abstract

Section: Introductionmentioning

confidence: 99%

Spiro Derivatives in the Discovery of New Pesticides: A Research Review

Dai

Zhang

et al. 2022

J. Agric. Food Chem.

View full text Add to dashboard Cite

show abstract

“…Currently, due to the nature of high quantum yield and readily synthetic process, some pyrazoline derivatives have been synthesized and used in fluorescence probes, for orientation 4 , detecting cation 5 – 8 , hydrazine 9 , 10 , thiols 11 – 13 , and DNA 14 . Moreover, their biological roles have been studied in insecticidal function 15 – 17 , human monoamine oxidase activity inhibition 18 , 19 , anti-inflammation 20 – 22 , antimicrobial 23 , 24 , analgesia 25 . In addition, pyrazoline derivatives could inhibit the proliferation of cancer cells with satisfactory activity 26 , 27 .…”

Section: Introductionmentioning

confidence: 99%

Discovery of new fluorescent thiazole–pyrazoline derivatives as autophagy inducers by inhibiting mTOR activity in A549 human lung cancer cells

et al. 2020

View full text Add to dashboard Cite

A series of fluorescent thiazole–pyrazoline derivatives was synthesized and their structures were characterized by 1H NMR, 13C NMR, and HRMS. Biological evaluation demonstrated that these compounds could effectively inhibit the growth of human non-small cell lung cancer (NSCLC) A549 cells in a dose- and time-dependent manner in vitro and inhibit tumor growth in vivo. The structure–activity relationship (SAR) of the compounds was analyzed. Further mechanism research revealed they could induce autophagy and cell cycle arrest while had no influence on cell necrosis. Compound 5e inhibited the activity of mTOR via FKBP12, which could be reversed by 3BDO, an mTOR activator and autophagy inhibitor. Compound 5e inhibited growth, promoted autophagy of A549 cells in vivo. Moreover, compound 5e showed good selectivity with no influence on normal vascular endothelial cell growth and the normal chick embryo chorioallantoic membrane (CAM) capillary formation. Therefore, our research provides potential lead compounds for the development of new anticancer drugs against human lung cancer.

show abstract

“…Dawane et al 22 synthesize some new series of 1-(4-(4'-chlorophenyl)-2-thiazolyl)-3-aryl-5 -(2-butyl-4-chloro-1H-imidazol-5yl) -2 -pyrazolines (1v)and their antimicrobial profile was studied. Potential anti-bacterial activities of C-12 pyrazolinyl spiro ketolide derivatives (1w) were reported by L. Hu et al 23 .…”

Section: P Vaidya Et Almentioning

confidence: 99%

Untitled

2015

IJPSR

View full text Add to dashboard Cite

show abstract

Synthesis and antibacterial activity of C-12 pyrazolinyl spiro ketolides

Cited by 13 publications

References 13 publications

Spiro Derivatives in the Discovery of New Pesticides: A Research Review

Spiro Derivatives in the Discovery of New Pesticides: A Research Review

Discovery of new fluorescent thiazole–pyrazoline derivatives as autophagy inducers by inhibiting mTOR activity in A549 human lung cancer cells

Untitled

Contact Info

Product

Resources

About