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Abstract

Pyrazoline, among the various 5-membered heterocyclic compound derivatives has drawn attention towards it because of its various pharmacologically activities associated with it. Pyrazolines are a five membered heterocyclic having two adjacent nitrogen atoms within the ring with only one endocyclic double bond and is basic in nature.

Synthesis, characterization and antitubercular evaluation of some new isoxazole appended 1-carboxamido-4,5-dihydro-1H-pyrazoles

“…Dihydropyrazole (Pyrazoline) is a heterocyclic scaffold of interest to medicinal chemists worldwide because of its ease of synthesis and a broad spectrum of bioactivities. In the recent past, scientists have reviewed [2][3][4][5][6] the pharmacological and physicochemical properties of dihydropyrazoles. Pyrazolines possess sundry of activities including antimicrobial [7][8][9], anticancer [10][11][12], antioxidant [13], antiamoebic [14], antiinflammatory [15], antidiabetic [16], diuretic [17] and carbonic anhydrase inhibition [18].…”

3-Pyrazolines (2,3-dihydro-1H-pyrazoles): synthesis, reactivity, and physical and biological properties

“…The main advantage of the old names is that the numbering of the atoms is the same for 2-pyrazolines, for instance a 3-methyl substituent in a 2-pyrazoline maintains the numbering in a 2,3-dihydro-1H-pyrazole but not for 3-pyrazolines, e.g., 3-methyl-3-pyrazoline corresponds to 5methyl-2,3-dihydro-1H-pyrazole. A search of the literature affords compounds that are named 3-or 4pyrazolines but are actually 2-pyrazolines, [1][2][3][4][5][6] or 1-pyrazolines 1,7-11 and 2,3-dihydro-1H-pyrazoles when they are 4,5-dihydro-1H-pyrazoles. This discrepancy in nomenclature made it difficult to search databases.…”