Synthetic Strategies, Reactivity and Applications of 1,5-Naphthyridines

Abstract

This review covers the synthesis and reactivity of 1,5-naphthyridine derivatives published in the last 18 years. These heterocycles present a significant importance in the field of medicinal chemistry because many of them exhibit a great variety of biological activities. First, the published strategies related to the synthesis of 1,5-naphthyridines are presented followed by the reactivity of these compounds with electrophilic or nucleophilic reagents, in oxidations, reductions, cross-coupling reactions, modification of side chains or formation of metal complexes. Finally, some properties and applications of these heterocycles studied during this period are examined.

New dinuclear gold(III) complex with 1,5-naphthyridine as bridging ligand: synthesis, characterization, DNA/BSA binding studies, and anticancer activity

“…Therefore, the mentioned nitrogen-donor ligand can be used in central nervous system, for cardiovascular or hormonal diseases. [14] Although previous work suggests the proteins are the primary target for gold(III) complexes, there is also huge importance to study the interactions with DNA molecules. [8] [15,16] DNA molecules affect cellular function and represent an excellent drug target, especially for cancer.…”

Naphthyridine Derivatives Induce Programmed Cell Death in Naegleria fowleri

“…The low toxicity of natural products containing chromene and their broad pharmacological properties are attractive features for medicinal chemists and a source of inspiration for the design of novel therapeutic agents [27]. The naphthyridine (Figure 1) ring has gained attention, becoming an important pharmacophore in the discovery of new biological agents due to its attractive biological activities [29]. In this sense, several naphthyridine derivatives present good pharmacological activity with low toxicity [30].…”

“…In recent years, our collaborating group has developed the synthesis of fused 1,5 naphthyridine derivatives such as chromeno 4,3-b 1,5 naphthyridine (I) and chromenone 4,3-b 1,5 naphthyridine (II) and fused 1,8 naphthyridine derivatives such as chromeno The naphthyridine (Figure 1) ring has gained attention, becoming an important pharmacophore in the discovery of new biological agents due to its attractive biological activities [29]. In this sense, several naphthyridine derivatives present good pharmacological activity with low toxicity [30].…”