Synthetic routes to singly and doubly bridged porphyrins

Synthèse de méso-α,γ bis(diamino-2,6 phényl) porphyrines

“…Les spectres de rmn "C et 'La synthkse du diacttamido-2,6 benzaldthyde a CtC rCalisCe au laboratoire par une autre mCthode qui sera dtcrite dans une autre publication. 33,09,23,73,22,45,14,53,13,93,11,25,10,63 (nBu,2 pyrroles Me, C02-CH,); sm (M = 223): pics a 223, 180, 134.…”

“…La recherche de modeles de l'hkmoglobine a conduit divers groupes a synthktiser des porphyrines a piquets (1) ou des porphyrines a anses (2). Les porphyrines a anses dkja synthktiskes ne cornportent qu'une seule anse, ou deux anses indkpendantes (une sur chaque face du squelette porphyrinique).…”

Cyclophanes as Synthetic Analogs of Enzymes and Receptors

“…The structure of vancomycin (3) l21>143>14 4 shows that the polycyclic cyclophane system included in the structure holds the binding sites in the polypeptide backbone 3 Vancomycin R = Sugars in positions that are appropriate for substrate binding. Thus, antibiotics of the vancomycin group owe their biological activity to their capacity to form complexes with Af-acyl derivatives of DAla-DAla, leading to the prevention of the biosynthesis of bacterial cell walls.…”