Synthetic routes to rhodanine scaffolds

Recent advances in the multicomponent synthesis of heterocycles using tetronic acid

“…Subsequently, an intermolecular Michael addition between intermediate B and anilolactone (29) yielded intermediate C. This was further transformed into its enamine form. The desired product (30) was nally obtained through cyclocondensation and tautomerization, facilitated by the intramolecular nucleophilic attack of the enamine N atom on the cyano group. (32) with yields ranging from satisfactory to high.…”

“…Although its luminescence properties were still preliminary, the results indicated its potential use as a chemical sensor across different solvents and pH levels. 29), benzaldehydes (2), and ammonium acetate (30) in glacial acetic acid using a microwave reaction. Yields ranged from good to moderate (Scheme 10).…”

“…As such, the amalgamation of one-pot multicomponent strategies with diverse methodologies expedites the synthesis of biologically pertinent heterocycles, a cornerstone of 21st-century organic chemistry. [24][25][26][27][28] In a bid to extend research in the eld of heterocyclic scaffold synthesis through multicomponent reactions, [29][30][31][32][33][34] this work emphasizes the recurrent use of tetronic acid as an initial substrate in the synthesis of these compounds. The objective of this study is to examine the recent advancements in multicomponent reactions involving tetronic acid, a highly versatile moiety in heterocyclic chemistry, as a central structural motif for heterocyclic compounds.…”

Recent applications of aminouracil in multicomponent reactions

“…In this case, 7-aminonaphthalene-1,3-disulfonic acid (ANDSA)-functionalized magnetic Fe3O4@SiO2 particles were employed as a hetrerogeneous catalyst. They carried out an efficient and one-pot multicomponent procedure for the synthesis of substituted pyrimido [4,5-d]pyrimidines (52) via reaction of N,N'-dimethyl-6-aminouracil (2), isothiocyanate (51), and aromatic aldehydes (1) in water as a green solvent and without using any other harmful organic reagents under the optimized conditions (Scheme 27). Scheme 27.…”

“…This method proved to be of considerable utility to researchers to obtain desired complex heterocyclic frameworks by condensation of more than two reactants in a single operational step. [41][42][43][44][45][46][47][48] Herein, in continuation of studies towards the synthesis of heterocyclic scaffolds via multicomponent reactions, [49][50][51][52] and because the 6-aminouracil is frequently used as a starting material in synthesizing these compounds. This review is devoted to recent applications of 6-aminouracil and its derivatives in synthesizing diverse heterocyclic compounds based on MCRs from 2015 to 2020.…”