Application of phenacyl bromide analogs as a versatile organic intermediate for the synthesis of heterocyclic compounds via multicomponent reactions

Recent advances in the multicomponent synthesis of heterocycles using tetronic acid

“…A novel, convenient, and signicant domino synthetic protocol has been described by Van 23) was employed, utilizing the reaction between tetronic acid (1) and substituted anilines (15). 46 The model reaction was used for the preparation of furo[3,4-b] quinoline-1,5,10(3H)-trione derivatives as a way to demonstrate the convenient strategy for the preparation of furo [3,4-b]quinoline-1,5,10(3H)-trione derivatives (34). In order to produce the nal product, some sequential multi-step reactions must be carried out including Knoevenagel condensation, Michael's addition, the shi of hydrogen, intramolecular cyclocondensation reaction, and nally through the loss of water molecules.…”

“…As such, the amalgamation of one-pot multicomponent strategies with diverse methodologies expedites the synthesis of biologically pertinent heterocycles, a cornerstone of 21st-century organic chemistry. [24][25][26][27][28] In a bid to extend research in the eld of heterocyclic scaffold synthesis through multicomponent reactions, [29][30][31][32][33][34] this work emphasizes the recurrent use of tetronic acid as an initial substrate in the synthesis of these compounds. The objective of this study is to examine the recent advancements in multicomponent reactions involving tetronic acid, a highly versatile moiety in heterocyclic chemistry, as a central structural motif for heterocyclic compounds.…”

“…In a bid to extend research in the field of heterocyclic scaffold synthesis through multicomponent reactions, 29–34 this work emphasizes the recurrent use of tetronic acid as an initial substrate in the synthesis of these compounds. The objective of this study is to examine the recent advancements in multicomponent reactions involving tetronic acid, a highly versatile moiety in heterocyclic chemistry, as a central structural motif for heterocyclic compounds.…”

Recent Advances in Multicomponent Electro‐Organic (Electrochemical) Synthesis of Heterocycles

“…Electrochemical multicomponent reactions can be used as a sustainable tool to synthesize, develop and study novel heterocycle scaffolds [7–12] . With continued progress and development, electro‐organic heterocycle synthesis has the potential to revolutionize heterocyclic chemistry.…”

“…[4][5][6] Electrochemical multicomponent reactions can be used as a sustainable tool to synthesize, develop and study novel heterocycle scaffolds. [7][8][9][10][11][12] With continued progress and development, electro-organic heterocycle synthesis has the potential to revolutionize heterocyclic chemistry. This review describes recent progresses (from 2015 to 2023) made in the synthesis of heterocyclic frameworks using multi-component electro-organic reactions.…”