Recent Advances in Multicomponent Electro‐Organic (Electrochemical) Synthesis of Heterocycles

Abstract

In terms of pharmaceuticals and biological applications, synthesis of complex organic molecules is a significant and fast‐developing area. In this context, organic electrosynthesis is an alternative way to the traditional methods for chemo‐, regio‐, and stereoselective syntheses. Electro‐organic reactions occur at room temperature and normal pressure, through transferring electrons. It has been found that electrosynthesis is a mild approach for preparing electrophilic substrates, bases, and nucleophiles in situ, from highly stable and low‐level reagents; which can be further applied to make heterocycles more accessible. While several promising methods exist, multi‐component reactions (MCRs) have drawn much attention both in academia and industry worldwide, since they are cost‐efficient and environmentally friendly. Combining the electrosynthesis and MCRs has produced a great strategy in the field of organic synthesis for industry and research. This review focuses on recent advances in the electrochemical synthesis of heterocyclic compounds via multi‐component reactions, reported between 2015 and March 2023.

Latest developments in coumarin-based anticancer agents: mechanism of action and structure–activity relationship studies

“…It is worth noting that we recently published some interesting review articles regarding multicomponent reactions. 63,64 A novel series of coumarin-benzimidazole hybrids was obtained and their growth inhibitory effect (in vitro) was studied against six cancer cell lines (A549, H460, HT29, MKN-45, U87MG, and SMMC-7721) using foretinib as the standard reference. 65 The studies indicated that compounds 26a-d (Fig.…”

“…It is worth noting that we recently published some interesting review articles regarding multicomponent reactions. 63,64…”

Recent Advances in the Multicomponent Synthesis of Heterocycles Using 5-Aminotetrazole

“…In this work, we have reviewed recent progress in multicomponent reactions using 5-aminotetrazole as a building block. 31 32 33 34 35 36 This article discusses 5-aminotetrazole as a key molecule in synthesizing heterocyclic compounds reported in the literature from 2017 to 2023.…”

Producing p‐tolylmethanol derivatives through an eco‐friendly electro‐organic method: A highly efficient Grignard reaction utilizing a magnesium electrode

“…31 Electrochemistry also provides precise control over reaction conditions, leading to improved selectivity and yield, thereby reducing the need for resource-intensive purification steps. 32 Additionally, electro-synthesis often involves the use of benign and readily available starting materials, contributing to the overall eco-friendliness of the process. As the demand for sustainable manufacturing practices continues to rise, electro-synthesis emerges as a promising avenue for achieving green chemistry objectives, paving the way for a more environmentally conscious and responsible approach to chemical synthesis.…”

“…This innovative technique leverages renewable energy sources, such as solar or wind power, to generate the required electrical energy, aligning with the principles of sustainability 31 . Electrochemistry also provides precise control over reaction conditions, leading to improved selectivity and yield, thereby reducing the need for resource‐intensive purification steps 32 . Additionally, electro‐synthesis often involves the use of benign and readily available starting materials, contributing to the overall eco‐friendliness of the process.…”