Synthetic polymeric biomaterials for tissue engineering

Kannan, Rahasudha; Wei, Guobao; Peter, X.

doi:10.1016/b978-0-12-820508-2.00023-4

Cited by 7 publications

(13 citation statements)

References 134 publications

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“…When applied in vivo, PCL proves to be stable and shows no visible degradation after 6 months [18]. PCL has been used in the production of hard (bone and dental applications) and soft tis- [16,[37][38][39][40][41] 2.1.1. Poly(ε-caprolactone) (PCL) PCL is an extremely tough aliphatic polyester and is widely used in various biomedical applications [16].…”

Section: Poly(ε-caprolactone) (Pcl)mentioning

confidence: 99%

“…PCL has been used in the production of hard (bone and dental applications) and soft tis- [16,[37][38][39][40][41] 2.1.1. Poly(ε-caprolactone) (PCL) PCL is an extremely tough aliphatic polyester and is widely used in various biomedical applications [16]. It is a polymer with repeating hexanoate units and has a low melting point of 60 • C. PCL is bioresorbable and has good stiffness, mechanical elasticity, thermal stability, biocompatibility, and rheological and viscoelastic properties.…”

Section: Poly(ε-caprolactone) (Pcl)mentioning

confidence: 99%

“…It is a polymer with repeating hexanoate units and has a low melting point of 60 • C. PCL is bioresorbable and has good stiffness, mechanical elasticity, thermal stability, biocompatibility, and rheological and viscoelastic properties. It has low decomposition rates and is highly flammable, non-toxic, and inexpensive [16]. On the other hand, poor cell adhesion and slow degradability are disadvantages of this synthetic biopolymer [17].…”

Section: Poly(ε-caprolactone) (Pcl)mentioning

confidence: 99%

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Resorbable Biomaterials Used for 3D Scaffolds in Tissue Engineering: A Review

Vach Agocsova,

Culenova,

Birova

et al. 2023

Materials

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This article provides a thorough overview of the available resorbable biomaterials appropriate for producing replacements for damaged tissues. In addition, their various properties and application possibilities are discussed as well. Biomaterials are fundamental components in tissue engineering (TE) of scaffolds and play a critical role. They need to exhibit biocompatibility, bioactivity, biodegradability, and non-toxicity, to ensure their ability to function effectively with an appropriate host response. With ongoing research and advancements in biomaterials for medical implants, the objective of this review is to explore recently developed implantable scaffold materials for various tissues. The categorization of biomaterials in this paper includes fossil-based materials (e.g., PCL, PVA, PU, PEG, and PPF), natural or bio-based materials (e.g., HA, PLA, PHB, PHBV, chitosan, fibrin, collagen, starch, and hydrogels), and hybrid biomaterials (e.g., PCL/PLA, PCL/PEG, PLA/PEG, PLA/PHB PCL/collagen, PCL/chitosan, PCL/starch, and PLA/bioceramics). The application of these biomaterials in both hard and soft TE is considered, with a particular focus on their physicochemical, mechanical, and biological properties. Furthermore, the interactions between scaffolds and the host immune system in the context of scaffold-driven tissue regeneration are discussed. Additionally, the article briefly mentions the concept of in situ TE, which leverages the self-renewal capacities of affected tissues and highlights the crucial role played by biopolymer-based scaffolds in this strategy.

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Section: Poly(ε-caprolactone) (Pcl)mentioning

confidence: 99%

Section: Poly(ε-caprolactone) (Pcl)mentioning

confidence: 99%

Section: Poly(ε-caprolactone) (Pcl)mentioning

confidence: 99%

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Resorbable Biomaterials Used for 3D Scaffolds in Tissue Engineering: A Review

Vach Agocsova,

Culenova,

Birova

et al. 2023

Materials

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“…Compared to natural polymers, synthetic ones are cost-efficient, present suitable mechanical properties, and show consistent results. 75 From a wide range of synthetic polymers, Poly lactic acid (PLA), PCL, PLCL, PGA, PLGA and Poly vinyl alcohol (PVA) are the most used in periodontal research. 76 PLA, which is used as a bioabsorbable membrane in some research, demonstrates high hydrophilicity, low cytotoxicity, high alkalinity and due to its predictable results, it is widely used in different periodontal studies.…”

Section: Synthetic Polymer-based Layered Scaffolds For Periodontal Re...mentioning

confidence: 99%

Layered scaffolds in periodontal regeneration

Abedi¹,

Rajabi²,

Kharaziha³

et al. 2022

Journal of Oral Biology and Craniofacial Research

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“…Polymeric hydrogel is often utilized for injecting vocal folds due to its ease of usage, biomimicry, and capacity to produce irregular shapes in confined spaces [ 59 ]. Polymeric hydrogel can be fabricated using synthetic or natural molecules [ 60 ], as shown in Supplementary Figure S1 . It can be crosslinked by either physical or chemical processes.…”

Section: Tissue Engineering As a Promising Treatment For Glottic Insu...mentioning

confidence: 99%

Tissue Engineering as a Promising Treatment for Glottic Insufficiency: A Review on Biomolecules and Cell-Laden Hydrogel

Lokanathan

Baki

et al. 2022

Biomedicines

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Glottic insufficiency is widespread in the elderly population and occurs as a result of secondary damage or systemic disease. Tissue engineering is a viable treatment for glottic insufficiency since it aims to restore damaged nerve tissue and revitalize aging muscle. After injection into the biological system, injectable biomaterial delivers cost- and time-effectiveness while acting as a protective shield for cells and biomolecules. This article focuses on injectable biomaterials that transport cells and biomolecules in regenerated tissue, particularly adipose, muscle, and nerve tissue. We propose Wharton’s Jelly mesenchymal stem cells (WJMSCs), induced pluripotent stem cells (IP-SCs), basic fibroblast growth factor (bFGF), vascular endothelial growth factor (VEGF), hepatocyte growth factor (HGF), insulin growth factor-1 (IGF-1) and extracellular vesicle (EV) as potential cells and macromolecules to be included into biomaterials, with some particular testing to support them as a promising translational medicine for vocal fold regeneration.

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Synthetic polymeric biomaterials for tissue engineering

Cited by 7 publications

References 134 publications

Resorbable Biomaterials Used for 3D Scaffolds in Tissue Engineering: A Review

Resorbable Biomaterials Used for 3D Scaffolds in Tissue Engineering: A Review

Layered scaffolds in periodontal regeneration

Tissue Engineering as a Promising Treatment for Glottic Insufficiency: A Review on Biomolecules and Cell-Laden Hydrogel

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