Layered scaffolds in periodontal regeneration

Abedi, Niloufar; Rajabi, Negar; Kharaziha, Mahshid; Nejatidanesh, Farahnaz; Tayebi, Lobat

doi:10.1016/j.jobcr.2022.09.001

Cited by 13 publications

(20 citation statements)

References 112 publications

(117 reference statements)

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“…In this approach, 3D structures are generated layer-by-layer based on CAD, incorporating stem cells, biomaterials, and growth factors, facilitating the development of multiphasic scaffolds, with each layer designed to regenerate a specific section of the periodontium. 82 These scaffolds are designed according to a hierarchical architecture capable of guiding the tissue regeneration that takes place simultaneously. This is an ideal approach for tissues with sophisticated anatomy and is useful for establishing connections between soft and hard tissues.…”

Section: Current Trends and Future Perspectives In Regenerative Denti...mentioning

confidence: 99%

Advances in Regenerative Dentistry Approaches: An Update

Thalakiriyawa

Dissanayaka

2024

International Dental Journal

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Section: Current Trends and Future Perspectives In Regenerative Denti...mentioning

confidence: 99%

Advances in Regenerative Dentistry Approaches: An Update

Thalakiriyawa

Dissanayaka

2024

International Dental Journal

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“…On the other hand, techniques such as SLA could overcome these limitations, but novel materials with better characteristics should be developed [ 6 ]. The fabrication of layered scaffolds through conventional methods including electrospinning, solvent casting, gas-foaming, and freeze drying may have benefits regarding high porosity, good pore interconnectivity, and low production costs, but the complexity of alveolar bone and periodontium requires novel fabrication techniques [ 224 ].…”

Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

Recent Advances in Scaffolds for Guided Bone Regeneration

Valamvanos,

Dereka,

Katifelis

et al. 2024

Biomimetics

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The rehabilitation of alveolar bone defects of moderate to severe size is often challenging. Currently, the therapeutic approaches used include, among others, the guided bone regeneration technique combined with various bone grafts. Although these techniques are widely applied, several limitations and complications have been reported such as morbidity, suboptimal graft/membrane resorption rate, low structural integrity, and dimensional stability. Thus, the development of biomimetic scaffolds with tailor-made characteristics that can modulate cell and tissue interaction may be a promising tool. This article presents a critical consideration in scaffold’s design and development while also providing information on various fabrication methods of these nanosystems. Their utilization as delivery systems will also be mentioned.

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“…Periodontal tissue (periodontium) is a sophisticated and functional tooth-surrounding tissue. Periodontium includes both hard and soft tissue, such as alveolar bone, periodontal ligament (PDL), cementum, and gingiva [ 99 ]. One of the most inflammatory diseases in dentistry is periodontitis.…”

Section: Role Of Antioxidant Materials In the Tissue Regeneration Pro...mentioning

confidence: 99%

Antioxidant Materials in Oral and Maxillofacial Tissue Regeneration: A Narrative Review of the Literature

et al. 2023

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Oral and maxillofacial tissue defects caused by trauma, tumor reactions, congenital anomalies, ischemic diseases, infectious diseases, surgical resection, and odontogenic cysts present a formidable challenge for reconstruction. Tissue regeneration using functional biomaterials and cell therapy strategies has raised great concerns in the treatment of damaged tissue during the past few decades. However, during biomaterials implantation and cell transplantation, the production of excessive reactive oxygen species (ROS) may hinder tissue repair as it commonly causes severe tissue injuries leading to the cell damage. These products exist in form of oxidant molecules such as hydrogen peroxide, superoxide ions, hydroxyl radicals, and nitrogen oxide. These days, many scientists have focused on the application of ROS-scavenging components in the body during the tissue regeneration process. One of these scavenging components is antioxidants, which are beneficial materials for the treatment of damaged tissues and keeping tissues safe against free radicals. Antioxidants are divided into natural and synthetic sources. In the current review article, different antioxidant sources and their mechanism of action are discussed. The applications of antioxidants in the regeneration of oral and maxillofacial tissues, including hard tissues of cranial, alveolar bone, dental tissue, oral soft tissue (dental pulp, periodontal soft tissue), facial nerve, and cartilage tissues, are also highlighted in the following parts.

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Layered scaffolds in periodontal regeneration

Cited by 13 publications

References 112 publications

Advances in Regenerative Dentistry Approaches: An Update

Advances in Regenerative Dentistry Approaches: An Update

Recent Advances in Scaffolds for Guided Bone Regeneration

Antioxidant Materials in Oral and Maxillofacial Tissue Regeneration: A Narrative Review of the Literature

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