Recent Advances in Scaffolds for Guided Bone Regeneration

Abstract

The rehabilitation of alveolar bone defects of moderate to severe size is often challenging. Currently, the therapeutic approaches used include, among others, the guided bone regeneration technique combined with various bone grafts. Although these techniques are widely applied, several limitations and complications have been reported such as morbidity, suboptimal graft/membrane resorption rate, low structural integrity, and dimensional stability. Thus, the development of biomimetic scaffolds with tailor-made characteristics that can modulate cell and tissue interaction may be a promising tool. This article presents a critical consideration in scaffold’s design and development while also providing information on various fabrication methods of these nanosystems. Their utilization as delivery systems will also be mentioned.

Dentistry and Cranio Facial District: The Role of Biomimetics

“…Valamvanos et al [23] reviewed the latest developments in scaffolds for guided bone regeneration. They highlighted the design of biomimetic scaffolds with controlled features in which cell and tissue interaction can be modulated.…”

“…This article highlights, with promising preclinical work, that more research needs to be undertaken in order to translate these findings to the clinic. This review underscores the critical role of biomimetic scaffolds in advancing regenerative medicine and improving outcomes in bone repair [23].…”