Synthetic Organic Compounds

Synthesis of 2,5-bisarylthiophenes was accomplished by sequential Suzuki cross coupling reaction of 2-bromo-5-chloro thiophenes. Density functional theory (DFT) studies were carried out at the B3LYP/6-31G(d, p) level of theory to compare the geometric parameters of 2,5-bisarylthiophenes with those from X-ray diffraction results. The synthesized compounds are screened for in vitro bacteria scavenging abilities. At the concentration of 50 and 100 μg/mL, compounds 2b, 2c, 2d, 3c, and 3f with IC50-values of 51.4, 52.10, 58.0, 56.2, and 56.5 μg/mL respectively, were found most potent against E. coli. Among all the synthesized compounds 2a, 2d, 3c, and 3e with the least values of IC50 77, 76.26, 79.13 μg/mL respectively showed significant antioxidant activities. Almost all of the compounds showed good antibacterial activity against Escherichia coli, whereas 2-chloro-5-(4-methoxyphenyl) thiophene (2b) was found most active among all synthesized compound with an IC50 value of 51.4 μg/mL. All of the synthesized compounds were screened for nitric oxide scavenging activity as well. Frontier molecular orbitals (FMOs) and molecular electrostatic potentials of the target compounds were also studied theoretically to account for their relative reactivity

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“…By following procedure reported by Garrat and co-workers [ 51 ] nitric oxide scavenging activity of all compounds was carried out.…”

Section: Methodsmentioning

confidence: 99%

One Pot Selective Arylation of 2-Bromo-5-Chloro Thiophene; Molecular Structure Investigation via Density Functional Theory (DFT), X-ray Analysis, and Their Biological Activities

Rasool

Kanwal

Rasheed

et al. 2016

IJMS

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“…For this , hippocampal tissue homogenate was combined with 10mM sodium nitroprusside that had been dissolved in phosphate buffered saline. 0.5 ml of Griess reagent was added after incubation, and absorbance was measured at 550 nm [26].…”

Section: Estimation Of Nitric Oxide (No) Activitymentioning

confidence: 99%

Neuroprotective Effects of Carotenoid Rich Verbesina encelioides Flower Extract in Scopolamine Induced Memory Impaired Rats Mimicking Alzheimer’s Disease

Dey,

Srivastava,

Sharma

et al. 2024

Preprint

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Neuron degeneration is the most common old age complications worldwide. Alzheimer's disease (AD) is one of the most common neurodegenerative condition with limited drug options and significant adverse effects. Hence, there is a growing interest in exploring natural products for their potential pharmacological activities against AD. This study investigates the efficacy of Verbesina encelioides flower extract (VFE) in alleviating neurobehavioral damage induced by Scopolamine in rat mimicking AD model. GC-MS analysis showed that V. encelioides flower extract is rich in carotenoids like spirilloxanthin. Various behavioural models were used to assess the rats' learning and memory capabilities. Additionally, biochemical tests were conducted on the AD rat models to evaluate oxidative stress in the brain, including superoxide dismutase (SOD), nitric oxide (NO), reduced glutathione (GSH), and anti-acetylcholinesterase (AChE) enzyme assays. Findings from this study suggest that the VFE significantly improved the rats' cognitive aptitude and alleviated them from oxidative stress by reducing free radical generation. Based on the results obtained from GC-MS analysis, in silico interaction analysis of gingkolide A and spirilloxanthin with acetylcholinesterase was carried out. In summary, this study suggests that V. enceloides flower extract improves learning abilities and mitigates cognitive deficits caused by scopolamine. Thus V. enceloides could be potentially seen as natural therapeutic intervention against neurodegenerative disorders likes Alzheimer’s disease and dementia.

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Aleksandr Nikolaevich Nesmeyanov

Sladkov¹

1969

Russ. Chem. Rev.

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We apply a classical treatment to the study of acoustoelectric interaction in nondegenerate n-type GaAs samples immersed in a magnetic field. The threshold electric field, and the incubation time as a function of the magnetic field, are compared with the experimental results by introducing in D L White's coefficient of amplification the mobility and diffusion constant corresponding to a mixed mode scattering. The variations of the saturation current are treated by taking into account the trapping of the carriers by the potential wave associated with the acoustic flux.

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Synthetic Organic Compounds

Cited by 4 publications

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One Pot Selective Arylation of 2-Bromo-5-Chloro Thiophene; Molecular Structure Investigation via Density Functional Theory (DFT), X-ray Analysis, and Their Biological Activities

One Pot Selective Arylation of 2-Bromo-5-Chloro Thiophene; Molecular Structure Investigation via Density Functional Theory (DFT), X-ray Analysis, and Their Biological Activities

Neuroprotective Effects of Carotenoid Rich Verbesina encelioides Flower Extract in Scopolamine Induced Memory Impaired Rats Mimicking Alzheimer’s Disease

Aleksandr Nikolaevich Nesmeyanov

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