Synthetic biology-driven microbial production of folates: Advances and perspectives

Yang, Han Mo; Zhang, Xiaolong; Liu, Yanfeng; Liu, Long; Li, Jianghua; Du, Guocheng; Chen, Jian

doi:10.1016/j.biortech.2020.124624

Cited by 7 publications

(3 citation statements)

References 136 publications

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“…Many microorganisms themselves can produce folate, such as lactic acid bacteria such as Lactococcus lactis, Streptococcus thermophilus, bifidobacteria, yeast, etc., but their production can only reach the level of micrograms based solely on their own metabolism [64,65]. For example, the Kefir yeast strains isolated by Patring et al had an average folate production of only 43 µg/L [66].…”

Section: Folatementioning

confidence: 99%

A New Direction for the Green, Environmentally Friendly and Sustainable Bioproduction of Aminobenzoic Acid and Its Derivatives

Xiao,

Zeng,

Wang

et al. 2024

Sustainability

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Aminobenzoic acid and its derivatives are a class of aromatic compounds that are important foundational chemicals for various dyes, food additives, and pharmaceuticals. Their production relies on chemical synthesis using petroleum-derived substances such as benzene as precursors, but due to the toxicity, environmental pollution, and non-renewable nature of raw materials in chemical synthesis, some suitable alternative methods are gradually being developed. Green, environmentally friendly, and sustainable biosynthesis methods have gradually been favored by researchers, especially after the discovery of the synthetic pathways of aminobenzoic acid and its derivatives in plants and microorganisms. Based on the purpose of protecting the ecological environment, reducing the use of non-renewable resources, and providing theoretical support for industrial green development, this article reviews the biosynthesis pathways of ortho-aminobenzoic acid, meta-aminobenzoic acid, para-aminobenzoic acid, and its derivatives such as catechol, folic acid, etc., and lists some examples of biosynthesis, analyzes their advantages and disadvantages, summarizes and looks forward to the future development direction of biosynthesis of aminobenzoic acid and its derivatives.

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Section: Folatementioning

confidence: 99%

A New Direction for the Green, Environmentally Friendly and Sustainable Bioproduction of Aminobenzoic Acid and Its Derivatives

Xiao,

Zeng,

Wang

et al. 2024

Sustainability

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“…Many properties should be considered when selecting hosts for natural products production. Due to a long history of research, microorganisms have been widely chosen because of mature techniques such as gene editing and large-scale fermentation, particularly for metabolic engineering ( Yang et al, 2021 ). With the increasing demand for resveratrol, many studies have focused on heterologous resveratrol production in prokaryotes such as Escherichia coli , Corynebacterium glutamicum and Streptomyces venezuelae , and in eukaryotes, including Saccharomyces cerevisiae and Yarrowia lipolytica ( Dudnik et al, 2018 ; Cravens et al, 2019 ).…”

Section: Microorganism Hosts For Resveratrol Productionmentioning

confidence: 99%

Synthetic Biology-Driven Microbial Production of Resveratrol: Advances and Perspectives

Feng

Chen

et al. 2022

Front. Bioeng. Biotechnol.

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Resveratrol, a bioactive natural product found in many plants, is a secondary metabolite and has attracted much attention in the medicine and health care products fields due to its remarkable biological activities including anti-cancer, anti-oxidation, anti-aging, anti-inflammation, neuroprotection and anti-glycation. However, traditional chemical synthesis and plant extraction methods are impractical for industrial resveratrol production because of low yield, toxic chemical solvents and environmental pollution during the production process. Recently, the biosynthesis of resveratrol by constructing microbial cell factories has attracted much attention, because it provides a safe and efficient route for the resveratrol production. This review discusses the physiological functions and market applications of resveratrol. In addition, recent significant biotechnology advances in resveratrol biosynthesis are systematically summarized. Furthermore, we discuss the current challenges and future prospects for strain development for large-scale resveratrol production at an industrial level.

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“…Vitamins are chemical substances whose derivatives are engaged in the vital metabolic pathways of all living organisms [1]. Since only bacteria, yeast and plants have endogenous routes for vitamin production, humans must obtain most of these crucial nutrients from food [2].…”

Section: Introductionmentioning

confidence: 99%

Folic Acid Ionic-Liquids-Based Separation: Extraction and Modelling

et al. 2023

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Folic acid (vitamin B9) is an essential micronutrient for human health. It can be obtained using different biological pathways as a competitive option for chemical synthesis, but the price of its separation is the key obstacle preventing the implementation of biological methods on a broad scale. Published studies have confirmed that ionic liquids can be used to separate organic compounds. In this article, we investigated folic acid separation by analyzing 5 ionic liquids (CYPHOS IL103, CYPHOS IL104, [HMIM][PF6], [BMIM][PF6], [OMIM][PF6]) and 3 organic solvents (heptane, chloroform, and octanol) as the extraction medium. The best obtained results indicated that ionic liquids are potentially valuable for the recovery of vitamin B9 from diluted aqueous solutions as fermentation broths; the efficiency of the process reached 99.56% for 120 g/L CYPHOS IL103 dissolved in heptane and pH 4 of the aqueous folic acid solution. Artificial Neural Networks (ANNs) were combined with Grey Wolf Optimizer (GWO) for modelling the process, considering its characteristics.

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Synthetic biology-driven microbial production of folates: Advances and perspectives

Cited by 7 publications

References 136 publications

A New Direction for the Green, Environmentally Friendly and Sustainable Bioproduction of Aminobenzoic Acid and Its Derivatives

A New Direction for the Green, Environmentally Friendly and Sustainable Bioproduction of Aminobenzoic Acid and Its Derivatives

Synthetic Biology-Driven Microbial Production of Resveratrol: Advances and Perspectives

Folic Acid Ionic-Liquids-Based Separation: Extraction and Modelling

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