Synthetic Biodegradable Polymers for Medical Applications

Suggs, Laura J.; Moore, Scott A.; Mikos, Antonios G.

doi:10.1007/978-0-387-69002-5_55

Cited by 28 publications

(20 citation statements)

References 68 publications

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“…However, PPF has greater hydrophobicity than OPF and has greater stiffness and strength [110, 111]. PPF has demonstrated to be photocrosslinkable [112], biocompatible in soft and hard tissues [113], osteoconductive [114], and effective in regenerating bone in a variety of animal models [111, 115, 116].…”

Section: Gelatin-based Compositesmentioning

confidence: 99%

Gelatin carriers for drug and cell delivery in tissue engineering

Santoro

Tatara

Mikos

2014

Journal of Controlled Release

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326

202

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The ability of gelatin to form complexes with different drugs has been investigated for controlled release applications. Gelatin parameters, such as crosslinking density and isoelectric point, have been tuned in order to optimize gelatin degradation and drug delivery kinetics. In recent years, focus has shifted away from the use of gelatin in isolation towards the modification of gelatin with functional groups and the fabrication of material composites with embedded gelatin carriers. In this review, we highlight some of the latest work being performed in these areas and comment on trends in the field. Specifically, we discuss gelatin modifications for immune system evasion, drug stabilization, and targeted delivery, as well as gelatin composite systems based on ceramics, naturally-occurring polymers, and synthetic polymers.

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Section: Gelatin-based Compositesmentioning

confidence: 99%

Gelatin carriers for drug and cell delivery in tissue engineering

Santoro

Tatara

Mikos

2014

Journal of Controlled Release

Self Cite

326

202

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“…The coiled heater that surrounds the syringe increases the temperature of the material in the syringe uniformly above the melting point. PCL, with a melting point of 57°C, was utilized in this material [33]. In order to extrude relatively low viscous polymer melts, the workable range of the processing temperature was determined to be 150 ± 5°C, which is higher than the melting temperature of PCL.…”

Section: The Dpmd Processmentioning

confidence: 99%

Development of dual scale scaffolds via direct polymer melt deposition and electrospinning for applications in tissue regeneration

et al. 2008

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“…PLGA has been demonstrated to be biocompatible and biodegradable. It is approved by the FDA for specific human clinical applications [2]. …”

Section: Introductionmentioning

confidence: 99%

Development of a novel bioerodible dexamethasone implant for uveitis and postoperative cataract inflammation

Chennamaneni

Mamalis

Archer

et al. 2013

Journal of Controlled Release

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Delivery of anti-inflammatory steroids concurrently to both anterior and posterior segments of the eye is a challenge. The anterior ocular structures limit topical delivery. Injection can be disproportionately and repeatedly invasive and selective for only one ocular hemisphere. We developed a novel implant that can compensate for the limited conveyance of topical medicine and reduce the repetitive invasiveness of injection from the capsular bag allowing dexamethasone (DXM) delivery to both the anterior and posterior chambers. To establish proof of concept, microparticles were prepared with PLGA [poly(d,l-lactide-co-glycolide), 50:50, MW. 7000–17000], hydroxypropyl methyl cellulose (HPMC), and DXM by oil-in-water emulsion/solvent evaporation technique. Zeatsizer Nano and SEM (scanning electron microscopy) results showed microspheres in the range of 8 ± 1 μM. The target load of DXM in the microparticles was ~20.0% with a % recovery of 99.9% (w/w). Dose related pharmacokinetics with near zero order kinetics was observed for up to 6 weeks in rabbits with intracapsular bag implants. DXM flow was bidirectional from the endocapsular space and significant concentrations were found in the anterior and posterior chambers after up to 6 weeks. Whereas, with topical drops the exposure was minimal in all the ocular tissues with greater systemic exposure. Intraocular pressure was normal in all of the study groups, slit lamp biomicroscopy examinations revealed that no cells or fibrin formation in the anterior and posterior chamber with implants but flare, cells and fibrin was present in the topical drops group. Histological examination revealed normal tissues and no signs of inflammation in all the groups. The implant did not migrate to the center of the eye or obstruct the visual axis. We believe these findings demonstrate the feasibility of drug delivery from the capsular bag to the anterior and posterior segments effectively compared to topical alternatives.

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Synthetic Biodegradable Polymers for Medical Applications

Cited by 28 publications

References 68 publications

Gelatin carriers for drug and cell delivery in tissue engineering

Gelatin carriers for drug and cell delivery in tissue engineering

Development of dual scale scaffolds via direct polymer melt deposition and electrospinning for applications in tissue regeneration

Development of a novel bioerodible dexamethasone implant for uveitis and postoperative cataract inflammation

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