Synthetic approaches to radiochemical probes for imaging of bacterial infections

Dutta, Jyotibon; Naicker, Tricia; Ebenhan, Thomas; Kruger, Hendrik G.; Arvidsson, Per I.; Govender, Thavendran

doi:10.1016/j.ejmech.2017.03.060

Cited by 22 publications

(12 citation statements)

References 188 publications

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“…The increasing incidence of bacterial infection with drug resistance is a major issue for human health ( Dutta et al, 2017 ). AuNPs are easily taken up by immune cells, due to their excellent cell affinity, which leads to precise delivery at the infected area, facilitating inhibition and damage to microbial pathogens ( Saha et al, 2007 ).…”

Section: Medical Applications Of Multifunctional Aunpsmentioning

confidence: 99%

Multifunctional Gold Nanoparticles: A Novel Nanomaterial for Various Medical Applications and Biological Activities

Zhang

Ding

et al. 2020

Front. Bioeng. Biotechnol.

362

206

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Nanotechnology has become a trending area in science and has made great advances with the development of functional, engineered nanoparticles. Various metal nanoparticles have been widely exploited for a wide range of medical applications. Among them, gold nanoparticles (AuNPs) are widely reported to guide an impressive resurgence and are highly remarkable. AuNPs, with their multiple, unique functional properties, and easy of synthesis, have attracted extensive attention. Their intrinsic features (optics, electronics, and physicochemical characteristics) can be altered by changing the characterization of the nanoparticles, such as shape, size and aspect ratio. They can be applied to a wide range of medical applications, including drug and gene delivery, photothermal therapy (PTT), photodynamic therapy (PDT) and radiation therapy (RT), diagnosis, X-ray imaging, computed tomography (CT) and other biological activities. However, to the best of our knowledge, there is no comprehensive review that summarized the applications of AuNPs in the medical field. Therefore, in this article we systematically review the methods of synthesis, the modification and characterization techniques of AuNPs, medical applications, and some biological activities of AuNPs, to provide a reference for future studies.

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Section: Medical Applications Of Multifunctional Aunpsmentioning

confidence: 99%

Multifunctional Gold Nanoparticles: A Novel Nanomaterial for Various Medical Applications and Biological Activities

Zhang

Ding

et al. 2020

Front. Bioeng. Biotechnol.

362

206

View full text Add to dashboard Cite

show abstract

“…In clinic, many infectious diseases are still diagnosed by their clinical presentation, but the clinical symptoms and signs of clinical manifestations are often unobvious in the early stage [5]. Although newly developed 67 Ga-citrate, 18 F-FDG, and radiolabeled leukocytes have been marketed as tracers for infection imaging and provide good sensitivity for early-stage diagnosis, these leukocyte and metabolic imaging methods are inherently non-specific, still failing to distinguish bacterial infections from other inflammatory disorders [6]. All of these prompt the continuous increase of misdiagnosis and subsequent mismanagement.…”

Section: Introductionmentioning

confidence: 99%

Beyond Antibiotics: Photo/Sonodynamic Approaches for Bacterial Theranostics

Pang

Zhu

et al. 2020

Nano-Micro Lett.

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Rapid evolution and propagation of multidrug resistance among bacterial pathogens are outpacing the development of new antibiotics, but antimicrobial photodynamic therapy (aPDT) provides an excellent alternative. This treatment depends on the interaction between light and photoactivated sensitizer to generate reactive oxygen species (ROS), which are highly cytotoxic to induce apoptosis in virtually all microorganisms without resistance concern. When replacing light with low-frequency ultrasonic wave to activate sensitizer, a novel ultrasound-driven treatment emerges as antimicrobial sonodynamic therapy (aSDT). Recent advances in aPDT and aSDT reveal golden opportunities for the management of multidrug resistant bacterial infections, especially in the theranostic application where imaging diagnosis can be accomplished facilely with the inherent optical characteristics of sensitizers, and the generated ROS by aPDT/SDT cause broad-spectrum oxidative damage for sterilization. In this review, we systemically outline the mechanisms, targets, and current progress of aPDT/SDT for bacterial theranostic application. Furthermore, potential limitations and future perspectives are also highlighted.

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“…In the study performed by Ozdemir et al., amoxicillin was labeled with 99m Tc. And in the review by Dutta et al., 99m Tc‐amoxicillin molecular structure was shown . Amoxicillin has similar structure ampicillin.…”

Section: Resultsmentioning

confidence: 98%

Preparation and evaluation of effect on Escherichia coli and Staphylococcus aureus of radiolabeled ampicillin‐loaded graphene oxide nanoflakes

et al. 2018

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Ampicillin is a one of effective antibiotics against Gram-positive and Gram-negative bacteria. This study aimed to label ampicillin-loaded graphene oxide nanoflake (AMP-GO) with Tc and evaluate of its in vitro binding to Staphylococcus aureus and Escherichia coli. Firstly, ampicillin was loaded into graphene oxide nanoflake prepared. AMP-GO was characterized by Fourier transform infrared spectroscopy (FTIR) and scanning electron microscope (SEM) techniques, and the amount of loaded ampicillin onto GO was determined by UV-Vis absorption spectroscopy. AMP and AMP-GO were labeled with Tc using stannous chloride reducing agent. Labeling efficiency of Tc-AMP-GO was found to be 97.66 ± 2.06%. Tc-AMP-GO has higher binding efficiencies to both S. aureus and E. coli than Tc-AMP. Tc-AMP-GO could be promising candidate as agent infection nuclear imaging. Furthermore, in vivo studies of Tc-AMP-GO with infected rats are planned to be performed.

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Synthetic approaches to radiochemical probes for imaging of bacterial infections

Cited by 22 publications

References 188 publications

Multifunctional Gold Nanoparticles: A Novel Nanomaterial for Various Medical Applications and Biological Activities

Multifunctional Gold Nanoparticles: A Novel Nanomaterial for Various Medical Applications and Biological Activities

Beyond Antibiotics: Photo/Sonodynamic Approaches for Bacterial Theranostics

Preparation and evaluation of effect on Escherichia coli and Staphylococcus aureus of radiolabeled ampicillin‐loaded graphene oxide nanoflakes

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