Synthetic approach toward spiro quinoxaline-β-lactam based heterocyclic compounds: Spectral characterization, SAR, pharmacokinetic and biomolecular interaction studies

Dabhi, Ravi A.; Dhaduk, Milan P.; Bhatt, Vaibhav D.; Bhatt, Bhupesh S.

doi:10.1080/07391102.2022.2086176

Cited by 8 publications

(1 citation statement)

References 55 publications

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“…Absorption, distribution, metabolism, and excretion (ADME) analysis predict the druggability of a molecule by studying its adherence with the ‘Lipinski Five’ Rules [ 60 ]. The pharmacokinetic properties and drug-likeness of novel amidic derivatives of Quinazolinone ( 7a-j ) were studied and compared with standard drug (Etoposide) using an online accessible web tool: ADMET lab 2.0 and SwissADME program of the Molecular Modelling Group of the Swiss Institute of Bioinformatics [ [61] , [62] , [63] , [64] , [65] , [66] ] which are publicly available at https://admet mesh.scbdd.com and http://www . Swissadme.ch, respectively.…”

Section: Resultsmentioning

confidence: 99%

Design, synthesis, in-silico studies and apoptotic activity of novel amide enriched 2-(1H)- quinazolinone derivatives

Gariganti,

Bandi,

Gatta

et al. 2024

Heliyon

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Section: Resultsmentioning

confidence: 99%

Design, synthesis, in-silico studies and apoptotic activity of novel amide enriched 2-(1H)- quinazolinone derivatives

Gariganti,

Bandi,

Gatta

et al. 2024

Heliyon

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Calix[4]pyrrole‐Grafted Gold Nanoparticles as a Turn‐On Fluorescence Sensor for Noxious Fungicide Dimoxystrobin and Their Anti‐Cancer Activity against the KB‐3‐1 Cell Line

Pomal

Bhatt

Kundariya³

et al. 2023

ChemistrySelect

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A rapid and easy approach for producing very stable gold nanoparticles has been discovered. Calix[4]pyrrole tetrahydrazide (CPTAH) was utilized effectively in the synthesis of gold nanoparticles as a reducing and stabilizing agent. These functionalized AuNPs were characterized by Surface Plasmon Resonance, Transmission Electron Microscopy, Selected Area Electron Diffraction, and Energy Dispersive X‐ray techniques. CPTAH‐AuNPs possessed a particle size of 11±2 nm and are highly stable at pH 7.0 for more than 150 days. The selectivity and sensitivity of CPTAH‐AuNPs as a fungicide sensor was assessed for Metalaxyl, Mancozeb, Tebuconazole, Tricyclozole, Dimoxystrobin, Kresoxim‐methyl, and Carbendazim, amongst which Dimoxystrobin (DMX) was sensed exclusively with naked eyes by means of aggregation of CPTAH‐AuNPs with a detection limit of the order of 5 ppm using “Turn‐on” fluorescence enhancement. Additionally, the CPTAH‐AuNPs were found to be effective cytotoxic agent against the human cervix cancer cell line KB‐3‐1 with IC50 value of 64.63 μg/mL which admits the employability of CPTAH‐AuNPs in the study of development of anti‐cancer drug.

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Synthesis of novel benzothieno-[3,2’-f][1,3] oxazepines and their isomeric 2-oxo-2H-spiro[benzothiophene-3,3’-pyrrolines] via 1,4-dipolar cycloaddition reaction and their evaluation as cytotoxic anticancer leads

Al-Mahadeen,

Jaber,

Zahra

et al. 2024

Med Chem Res

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Synthetic approach toward spiro quinoxaline-β-lactam based heterocyclic compounds: Spectral characterization, SAR, pharmacokinetic and biomolecular interaction studies

Cited by 8 publications

References 55 publications

Design, synthesis, in-silico studies and apoptotic activity of novel amide enriched 2-(1H)- quinazolinone derivatives

Design, synthesis, in-silico studies and apoptotic activity of novel amide enriched 2-(1H)- quinazolinone derivatives

Calix[4]pyrrole‐Grafted Gold Nanoparticles as a Turn‐On Fluorescence Sensor for Noxious Fungicide Dimoxystrobin and Their Anti‐Cancer Activity against the KB‐3‐1 Cell Line

Synthesis of novel benzothieno-[3,2’-f][1,3] oxazepines and their isomeric 2-oxo-2H-spiro[benzothiophene-3,3’-pyrrolines] via 1,4-dipolar cycloaddition reaction and their evaluation as cytotoxic anticancer leads

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