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A rapid and easy approach for producing very stable gold nanoparticles has been discovered. Calix[4]pyrrole tetrahydrazide (CPTAH) was utilized effectively in the synthesis of gold nanoparticles as a reducing and stabilizing agent. These functionalized AuNPs were characterized by Surface Plasmon Resonance, Transmission Electron Microscopy, Selected Area Electron Diffraction, and Energy Dispersive X‐ray techniques. CPTAH‐AuNPs possessed a particle size of 11±2 nm and are highly stable at pH 7.0 for more than 150 days. The selectivity and sensitivity of CPTAH‐AuNPs as a fungicide sensor was assessed for Metalaxyl, Mancozeb, Tebuconazole, Tricyclozole, Dimoxystrobin, Kresoxim‐methyl, and Carbendazim, amongst which Dimoxystrobin (DMX) was sensed exclusively with naked eyes by means of aggregation of CPTAH‐AuNPs with a detection limit of the order of 5 ppm using “Turn‐on” fluorescence enhancement. Additionally, the CPTAH‐AuNPs were found to be effective cytotoxic agent against the human cervix cancer cell line KB‐3‐1 with IC50 value of 64.63 μg/mL which admits the employability of CPTAH‐AuNPs in the study of development of anti‐cancer drug.

No abstract

A calix[4]pyrrole tetrahydrazide functionalized silver nanoparticles (CPTPH-AgNPs) coupled with colorimetric findings were prepared. In the variety of essential amino acids, it detected the L-Histidine exclusively with an LOD of 6.1 μM and LOQ of 18.5 μM. The CPTPH-AgNPs were exhibited the SPR spectrum at 408nm, which further characterized with TEM, EDEX and SAED in that they show the monodispersed spherical morphology of AgNPs with 13±2nm size. The antimicrobial potential of CPTPH-AgNPs towards Gram-positive bacterial-Staphylococcus aureus, Bacillus subtilis, Gram-negative bacteria-Escherichia coli, Pseudomonas aeruginosa and fungi-Aspergillus niger was evaluated.; in which it is found to give reasonable response comparable to standard antibiotic drugs.