2022
DOI: 10.1039/d2nr04040a
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Synthesizing the biochemical and semiconductor worlds: the future of nucleic acid nanotechnology

Abstract: Since its inception nearly 40 years ago [Kallenbach et al., Nature 305, 829, (1983); Seeman NC., J. Theoretical Biology 99, 237 (1982)], Nucleic Acid Nanotechnology (NAN) has matured and is...

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Cited by 3 publications
(1 citation statement)
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“…Several companies are nearing delivery of enzyme-based DNA synthesis technologies and making these commercially available to licensed vendors or acting as providers themselves. 458,459 This will be a welcome addition since it bypasses the initial costly phosphoramidite synthesis and will be a far greener approach in the long run. It is, however, not currently clear how these technologies can implement insertion of modified and much bulkier dye-labeled bases into nascent oligonucleotides.…”
Section: Discussionmentioning
confidence: 99%
“…Several companies are nearing delivery of enzyme-based DNA synthesis technologies and making these commercially available to licensed vendors or acting as providers themselves. 458,459 This will be a welcome addition since it bypasses the initial costly phosphoramidite synthesis and will be a far greener approach in the long run. It is, however, not currently clear how these technologies can implement insertion of modified and much bulkier dye-labeled bases into nascent oligonucleotides.…”
Section: Discussionmentioning
confidence: 99%