Pursuing excitonic energy transfer with programmable DNA-based optical breadboards

Abstract

Nanoscale dye-based excitonic systems assembled on DNA origami in solution excited by a laser. Dyes engage in cascaded FRET with exciton movement guided by programmed elements engaging in homo- and hetero-energy transfer.

Multiplexed DNA and Protease Detection with Orthogonal Energy Transfer on a Single Quantum Dot Scaffolded Biosensor

“…Coming full circle back to what makes all of this possible, it is the unique photophysical properties of the QD and its ability to act as a nanoscale scaffold and participate in different forms of FRET and CT as a donor, (TG)-acceptor, and/or relay depending upon how it is applied. Moreover, the unique structural properties of DNA assemblies can help achieve the requisite donor–acceptor positioning required for creating complex FRET systems around a QD. , …”

“…Moreover, the unique structural properties of DNA assemblies can help achieve the requisite donor−acceptor positioning required for creating complex FRET systems around a QD. 83,84 ■ ASSOCIATED CONTENT…”

Effect of hydrophilicity-imparting substituents on exciton delocalization in squaraine dye aggregates covalently templated to DNA Holliday junctions

“…Some examples include artificial light-harvesting, 2,5 nanoscale computing using quantum gates, 4,6–8 and biological and environmental sensing. 9,10 In a recent review, Mathur et al 11 suggested that quantum computing may be the most extensive impactful application of exciton delocalization, using methodologies provided by Yurke. 4,8…”

Dominant Analytical Techniques in DNA Nanotechnology for Various Applications

“…17, 18 Additionally, DNA nanoplatforms augment photonic and nanoparticle plasmonic properties, enabling control over light−matter interactions. 19,20 DNA even has a place in the realm of computing and information storage; it serves as a promising medium due to the potential for parallel processing. 21,22 These applications collectively demonstrate that DNA nanostructures are advancing various directions in basic science and technology.…”

“…Because of these unique features, DNA nanostructures regularly appear in the areas of biomedicine, biomolecular engineering, nanofabrication, and nanotechnology now. , DNA nanostructures enable the precise and targeted delivery of therapeutic agents to specific cells or tissues. − In functionalization of these structures, the topology can be modified with targeted ligands or antibodies that enhance selectivity and reduce side effects of different therapies. , In the realm of bioimaging, the platform can be tagged with fluorescent dyes or other imaging agents that enable visualization and high-resolution imaging of biological structures. , DNA nanostructures have also been employed in molecular sensing applications, where they can be functionalized with specific receptors to detect and quantify target analytes such as proteins. , Additionally, DNA nanoplatforms augment photonic and nanoparticle plasmonic properties, enabling control over light–matter interactions. , DNA even has a place in the realm of computing and information storage; it serves as a promising medium due to the potential for parallel processing. , …”