Synthesis, X‐ray Structure, and Pharmacological Activity of Some 6,6‐Disubstituted Chromeno[4,3‐<i>b</i>]‐ and Chromeno‐ [3,4‐<i>c</i>]‐quinolines

Hegab, Mohamed I.; Abdel-Fattah, Abdel-Samee M.; Yousef, Nabil M.; Nour, Hany F.; Mostafa, Ahmed; Ellithey, Mohey

doi:10.1002/ardp.200700089

Cited by 51 publications

(21 citation statements)

References 32 publications

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“…Amides in conjugation with other aliphatic, aromatic and heterocyclic rings produce various types of biological activity. They possess a wide spectrum of biological activities like antituberculosis, anticonvulsant, analgesic, anti‐inflammatory, insecticidal, antifungal and antitumour properties …”

Section: Introductionmentioning

confidence: 99%

Novel design of recyclable copper(II) complex supported on magnetic nanoparticles as active catalyst for Beckmann rearrangement in poly(ethylene glycol)

Keyhaniyan

Shiri

Eshghi

et al. 2018

Applied Organom Chemis

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Coppercomplex-functionalized magnetic core-shell nanoparticles (Fe 3 O 4 @SiO 2 -Lig-Cu) were prepared and characterized using various techniques. The activity of the new catalyst was tested for the Beckmann rearrangement. The reaction conditions allow for the conversion of a wide variety of aldoximes, including aromatic and heterocyclic ones, to amides in good to excellent yields. High efficiency, mild reaction conditions, easy work-up, use of poly(ethylene glycol) as a green medium and simple purification of products are important advantages of this system. Moreover, the eco-friendly heterogeneous nanocatalyst could be easily recovered from the reaction mixture using an external magnet and reused several times.

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Section: Introductionmentioning

confidence: 99%

Novel design of recyclable copper(II) complex supported on magnetic nanoparticles as active catalyst for Beckmann rearrangement in poly(ethylene glycol)

Keyhaniyan

Shiri

Eshghi

et al. 2018

Applied Organom Chemis

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“…1 Particularly, the chromenoquinoline skeleton is found in a variety of potential bioactive entities, such as -selective estrogen ligands (ER) 1, 2,3 antitumor agents 2 4,5 and anti-inflammatory derivative 3 (Figure 1). 6 Furthermore, due to their fluorescent properties, some chromeno [4,3-b]quinoline ana-logues 4, 5 have been used in fluorescent probes to study cell permeability and live-cell imaging of thiols and amino acids (Figure 1). [7][8][9] Figure 1 Representative bioactive chromeno [4,3-b]quinolines 1-5…”

Section: O + Omentioning

confidence: 99%

I2/DMSO-Promoted Synthesis of Chromeno[4,3-b]quinolines through an Imine Formation/Aza-Diels–Alder/Aromatization Tandem Reaction under Metal-Catalyst- and Photosensitizer-Free Conditions

et al. 2021

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A tandem approach was developed for the efficient synthesis of substituted chromeno[4,3-b]quinolines from arylamines and O-cinnamyloxy salicylaldehydes under metal-catalyst and photosensitizer-free reaction conditions. Our protocol is based on an inexpensive I2/DMSO system in which molecular iodine first acts as a Lewis acid to promote the formation of the corresponding imine bearing the alkene moiety, then, this species fulfills a second role by catalyzing the intramolecular aza-Diels-Alder cycloaddition to generate the respective tetrahydro-chromenoquinolines as an intermediates. Finally, the dual behaviour of DMSO as an oxidant and as a solvent resulted crucial at this stage, allowing the regeneration of I2 and promoting the aromatization of the tetrahydro-chromenoquinoline intermediates to yield the desired 7-aryl-6H-chromeno[4,3-b]quinolines. This protocol features by being mild, easy to perform, high step-economy (tandem process) and for providing a new access to biologically important nitrogen and oxygen containing heterocyclic molecules.

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“…Alkyl and Aryl amides have wide range of biological functionalities. Number of aromatic and heterocyclic amide derivatives have been associated with various types of biological activities like antituberculosis, anti‐inflammatory, anticonvulsant, antiplatelet, antitumor and antifungal …”

Section: Quinone Oxadiazole and β‐Lactam Derivativesmentioning

confidence: 99%

Recent Advances and Developments of in vitro Evaluation of Heterocyclic Moieties on Cancer Cell Lines

Tandon

Singh

Luxami

et al. 2018

The Chemical Record

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Besides worthy development in cancer therapy, cancer is still one of the leading causes of death, worldwide. The future burden of cancer will probably be even larger because people are adopting poor lifestyles with poor diet, frequently smoking and less physical activity. The effective anticancer drugs having efficacy and selectivity with low toxicity is still a challenge for the scientific fraternity. The advances in the cancer study have its origin on the availability of different types of experimental model systems that review the various forms of this disease. Cell lines emerge as a feasible alternative for anticancer activities, being at the same time easy to manipulate and molecularly characterize. Heterocycles are key structural components of many of the anti-cancer drugs available on the market today. Indeed, of the novel molecular anti-cancer agents approved by the FDA between 2010 and 2017, almost two-thirds contained heterocyclic rings within their structures. This review summarizes and provides updated literature on heterocyclic compounds using various cancer cell lines reported during the period of 2014-2017 together with the structure-activity relationships.

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Synthesis, X‐ray Structure, and Pharmacological Activity of Some 6,6‐Disubstituted Chromeno[4,3‐b]‐ and Chromeno‐ [3,4‐c]‐quinolines

Cited by 51 publications

References 32 publications

Novel design of recyclable copper(II) complex supported on magnetic nanoparticles as active catalyst for Beckmann rearrangement in poly(ethylene glycol)

Novel design of recyclable copper(II) complex supported on magnetic nanoparticles as active catalyst for Beckmann rearrangement in poly(ethylene glycol)

I2/DMSO-Promoted Synthesis of Chromeno[4,3-b]quinolines through an Imine Formation/Aza-Diels–Alder/Aromatization Tandem Reaction under Metal-Catalyst- and Photosensitizer-Free Conditions

Recent Advances and Developments of in vitro Evaluation of Heterocyclic Moieties on Cancer Cell Lines

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