Synthesis, structures and anticancer studies of symmetrically and non-symmetrically aliphatic nitrile functionalized silver(I)-<i>N</i>-heterocyclic carbene and palladium(II)-<i>N</i>-heterocyclic carbene complexes

Hussaini, Sunusi Y.; Haque, Rosenani A.; Agha, M. Taleb; Majid, Amin Malik Shah Abdul; Razali, Mohd. R.

doi:10.1080/24701556.2018.1504074

Cited by 6 publications

(2 citation statements)

References 51 publications

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“…The newly Ag(I)‐NHC and Pd(II)‐NHC complexes ( 4 and 5 ) which have symmetrically and unsymmetrically nitrile functionalization were synthesized by Hussaini et al (Figure 2) (Hussaini et al, 2018). Cytotoxic activity of complexes was assessed against MCF‐7 human breast cancer cell lines and in respect to that of tamoxifen as standard drug.…”

Section: Silver (Ag)mentioning

confidence: 99%

“…These results indicated that the complex 5 was three times more active than the standard drug tamoxifen (IC 50 of 11.2 ± 1.8 μM). Hussaini et al showed that increased in carbon side chain lengths (for complex 4, 1‐cyanobutyl‐3‐cyanopentyl; for complex 5 1,3‐dicyanopentyl) results in lower IC 50 values and increased the cytotoxic potential in Ag(I)‐NHC complexes (Hussaini et al, 2018).…”

Section: Silver (Ag)mentioning

confidence: 99%

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Silver(I)‐N‐heterocyclic carbene complexes challenge cancer; evaluation of their anticancer properties and in silico studies

Şahin‐Bölükbaşı

Cantürk-Kılıçkaya

Kılıçkaya

2021

Drug Development Research

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Because of the continuous need for efficient therapeutic agents against various kinds of cancers and infectious diseases, the pharmaceutical industry has to find new candidates and strategies to develop novel and efficient drugs. They increasingly use computational tools in R&D stages for screening extensive sets of drug candidates before starting pre‐clinical and clinical trials. N‐Heterocyclic carbenes (NHCs) can be evaluated as good drug candidates because they offer both anti‐cancer and anti‐inflammatory features with their general low‐toxicity profiles. To date, different kinds of NHCs (Cu, Co, Ni, Au, Ag, Ru, etc.) have been synthesized and their therapeutic uses has been shown. Here, we have reviewed the recent studies focused on Ag(I)‐NHC complexes and their anti‐cancer activities. Also, existing examples of the usage of density functional theory and structure–activity relationship have been evaluated.

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Section: Silver (Ag)mentioning

confidence: 99%

Section: Silver (Ag)mentioning

confidence: 99%

Silver(I)‐N‐heterocyclic carbene complexes challenge cancer; evaluation of their anticancer properties and in silico studies

Şahin‐Bölükbaşı

Cantürk-Kılıçkaya

Kılıçkaya

2021

Drug Development Research

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New morpholine‐liganded palladium(II) N‐heterocyclic carbene complexes: Synthesis, characterization, crystal structure, and DNA‐binding studies

Türker

Gürses

Celepci

et al. 2019

Archiv der Pharmazie

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A series of the morpholine‐liganded palladium(II) complexes (1a–e) bearing N‐heterocyclic carbene (NHC) functionalized by benzonitrile were synthesized. These complexes were synthesized from (NHC)Pd(II)(pyridine) complexes (PEPPSI) and morpholine. The new complexes were fully characterized by using 1H NMR, 13C NMR, Fourier‐transform infrared spectroscopy, and elemental analysis techniques. Single‐crystal X‐ray diffraction was used to determine the structure of a derivative. The DNA‐binding studies of the new (NHC)Pd(II)morpholine complexes were examined using the pBR322 plasmid. The 2,4,6‐trimethylbenzyl derivative compound has the most DNA binding activity. In addition, for the 3‐methylbenzyl derivative compound, oxidation effects were observed at concentrations higher than 100 µg/ml. Also, the molecular and crystal structures of the complex 3‐methylbenzyl derivative compound were recorded by using a single‐crystal X‐ray diffraction method.

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A critical review of palladium organometallic anticancer agents

Scattolin

Voloshkin

Visentin

et al. 2021

Cell Reports Physical Science

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Synthesis, structures and anticancer studies of symmetrically and non-symmetrically aliphatic nitrile functionalized silver(I)-N-heterocyclic carbene and palladium(II)-N-heterocyclic carbene complexes

Cited by 6 publications

References 51 publications

Silver(I)‐N‐heterocyclic carbene complexes challenge cancer; evaluation of their anticancer properties and in silico studies

Silver(I)‐N‐heterocyclic carbene complexes challenge cancer; evaluation of their anticancer properties and in silico studies

New morpholine‐liganded palladium(II) N‐heterocyclic carbene complexes: Synthesis, characterization, crystal structure, and DNA‐binding studies

A critical review of palladium organometallic anticancer agents

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