meta-Cyanobenzyl-substituted N-heterocyclic carbene (NHC) precursors were synthesized by the reaction of a series of N-(alkyl)benzimidazolium with 3-bromomethyl-benzonitrile. These benzimidazolium salts were characterized by using H NMR, C NMR, FTIR spectroscopy, and elemental analysis techniques. The molecular and crystal structures of 2f and 2g complexes were obtained by using the single-crystal X-ray diffraction method. The derivatives of these novel NHC precursors were effective inhibitors of α-glycosidase (AG), the cytosolic carbonic anhydrase I and II isoforms (hCA I and II), butyrylcholinesterase (BChE), and acetylcholinesterase (AChE) with K values in the range of 1.01-2.12 nM for AG, 189.56-402.44 nM for hCA I, 112.50-277.37 nM for hCA II, 95.45-352.58 nM for AChE, and 132.91-571.18 nM for BChE. In the last years, inhibition of the CA enzyme has been considered as a promising factor for pharmacologic intervention in a diversity of disturbances such as obesity, glaucoma, cancer, and epilepsy.

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A series of the morpholine‐liganded palladium(II) complexes (1a–e) bearing N‐heterocyclic carbene (NHC) functionalized by benzonitrile were synthesized. These complexes were synthesized from (NHC)Pd(II)(pyridine) complexes (PEPPSI) and morpholine. The new complexes were fully characterized by using 1H NMR, 13C NMR, Fourier‐transform infrared spectroscopy, and elemental analysis techniques. Single‐crystal X‐ray diffraction was used to determine the structure of a derivative. The DNA‐binding studies of the new (NHC)Pd(II)morpholine complexes were examined using the pBR322 plasmid. The 2,4,6‐trimethylbenzyl derivative compound has the most DNA binding activity. In addition, for the 3‐methylbenzyl derivative compound, oxidation effects were observed at concentrations higher than 100 µg/ml. Also, the molecular and crystal structures of the complex 3‐methylbenzyl derivative compound were recorded by using a single‐crystal X‐ray diffraction method.

Herein, we reported the synthesis of a new series of Pd-based complexes bearing N-heterocyclic carbene (NHC) and triphenylphosphine (PPh3) ligands.These complexes have been prepared from the (NHC)Pd(II)(pyridine) complexes and PPh3. All (NHC)Pd(II)PPh3 complexes have been characterized by using 1 H NMR, 13 C { 1 H}NMR, 31 P { 1 H}NMR, and FTIR spectroscopy and elemental analysis technique. Here, as a result of low catalyst [(NHC)Pd(II)PPh3] loading (0.01 mmol), acetylene derivatives with various functional groups were synthesized from the coupling of phenylacetylene with various aryl bromides in the aqueous medium.