Synthesis, Structure–Property Evaluation and Biological Assessment of Supramolecular Assemblies of Bioactive Glass with Glycyrrhizic Acid and Its Monoammonium Salt

Abstract

Medical nutrients obtained from plants have been used in traditional medicine since ancient times, owning to the protective and therapeutic properties of plant extracts and products. Glycyrrhizic acid is one of those that, apart from its therapeutic effect, may contribute to stronger bones, inhibiting bone resorption and improving the bone structure and biomechanical strength. In the present study, we investigated the effect of a bioactive glass (BG) addition to the structure–property relationships of supramolecular assemblies formed by glycyrrhizic acid (GA) and its monoammonium salt (MSGA). FTIR spectra of supramolecular assemblies evidenced an interaction between BG components and hydroxyl groups of MSGA and GA. Moreover, it was revealed that BG components may interact and bond to the carboxyl groups of MSGA. In order to assess their biological effects, BG, MSGA, and their supramolecular assemblies were introduced to a culture of human bone-marrow-derived mesenchymal stromal cells (BMSCs). Both the BG and MSGA had positive influence on BMSC growth, viability, and osteogenic differentiation—these positive effects were most pronounced when BG1d-BG and MSGA were introduced together into cell culture in the form of MSGA:BG assemblies. In conclusion, MSGA:BG assemblies revealed a promising potential as a candidate material intended for application in bone defect reconstruction and bone tissue engineering approaches.

Development and evaluation of gastro retentive drug delivery system of monoammonium glycyrrhizinate for the management of gastric ulcer

“…The peak at 3563 cm− 1 represented N-H symmetric stretching (Figure 3a.) [16]. The FTIR spectroscopy recorded for sodium alginate demonstrated characteristics peak at 3653.01 cm− 1 representing the characteristic stretching vibration of -OH (hydroxyl) group [17].…”

The State-of-the-Art Antibacterial Activities of Glycyrrhizin: A Comprehensive Review

“…This property serves as a drug delivery system, enhancing drug absorption [ 53 ]. GLY inclusion complexes can be utilized by a variety of compounds such as cholesterol [ 17 ], lagochiline [ 54 ], and paclitaxel [ 55 , 56 ]. The formation of inclusion complexes prolongs the action of drug compounds, enhances their stability, and reduces the therapeutic load/dose.…”