Synthesis, structure and spectral studies on mixed ligand copper(II) complexes of diimines and acetylacetonate

Onawumi, O. O. E.; Faboya, O.O.P.; Odunola, O. A.; Prasad, Thazhe Kootteri; Rajasekharan, M. V.

doi:10.1016/j.poly.2007.08.041

Cited by 40 publications

(21 citation statements)

References 14 publications

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“…18,19 In this regard casiopeinas, generic name of heteroleptic copper(II) complexes with good antineoplastic activity have set a foundation for synthesis of therapeutically potent agents based on mix ligand copper(II) complexes. 20,21 Moreover, copper complexes can act as enzyme inhibitors by blocking the active sites on enzyme surface as copper has ability to bind to various proteins in biological system. However, a very few copper carboxylates have been reported so far with alpha glucosidase, acetylcholine and butyrylcholine esterases inhibition activity.…”

Section: Introductionmentioning

confidence: 99%

New Bioactive Heteroleptic Copper(II) Carboxylates: Structure, Enzymatic and DNA-Binding Studies

Mushtaq

Ali

Tahir

et al. 2017

ACSi

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Two new binuclear O-bridged copper(II) carboxylates with chemical formulas [Cu 2 (3-ClC 6 H 4 CH 2 COO) 4 (phen) 2 ] (1) and [Cu 2 (3-ClC 6 H 4 CH 2 COO) 4 (bipy) 2 ] (2) where phen = 1,10-phenanthroline and bipy = 2,2'-bipyridine have been synthesized and characterized by FT-IR, UV-Visible spectroscopy, CHN analysis and single crystal XRD. The results revealed distorted square pyramidal geometry around each copper atom of 1 and 2. The DNA interaction studies showed strong binding with K b = 5.07 × 10 3 and 4.62 × 10 3 M -1 for 1 and 2, respectively. Both complexes showed strong enzyme inhibition, i.e., 70% and 90% for α-glucosidase with IC 50 = 34.6 and 30.1 μM for 1 and 2, respectively, where acarbose was employed as control. However, both the complexes were found inactive against α-amylase. Using galantamine hydrobromide as control, 1 showed moderate inhibition activity (47%) with IC 50 = 179.4 μM for acetylcholine esterase whereas 2 showed strong inhibition activity (76%) with IC 50 = 95.8 μM for butyrylcholine esterase. The data reflects active anti-diabetic and anti-Alzheimer's nature of the synthesized complexes.

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Section: Introductionmentioning

confidence: 99%

New Bioactive Heteroleptic Copper(II) Carboxylates: Structure, Enzymatic and DNA-Binding Studies

Mushtaq

Ali

Tahir

et al. 2017

ACSi

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“…This activity could have plenty of supporting antioxidant compounds present in the aqueous totum (Singh et al, 2013). Reduction in its antioxidant capacity was identified by thinlayer chromatography with a yellow color on a purple background (Onawumi et al, 2012). The antioxidant activity may be related to the presence of polar compounds with polyphenols (N'Guessan et al, 2011).…”

Section: Discussionmentioning

confidence: 99%

Antioxidant and anti-hyperglycaemic activity of <i>Euphorbia hirta</i> L. on Wistar rats

Fofie¹,

Sanogo²,

Diarra³

et al. 2014

Int. J. Bio. Chem. Sci

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The objective of this study was to investigate the antioxidant capacity and anti-hyperglycemic activity of aqueous macerate extracts of Euphorbia hirta L., in the treatment of hypertension associated with diabetes. The research focused on the aqueous maceration of the aerial part or totum. The search and evaluation of the antioxidant activity was done according to the method of Blois based on the reduction of 2,2-diphenyl-1-picrylhydrazyl (DPPH). The search for antihyperglycaemic activity was performed on rats having received a glucose overdose. This activity was compared to those of glyburide and metformin. The totum showed a percentage inhibition of 63.66 ± 0.54% for 1 mg/mL of extract and an IC 50 of 0.031 ± 0.001 µg/mL .A 200 mg/kg extract has shown a very good antihyperglycaemic activity; while on normal blood sugar, the activity was not important compared with glyburide and metformin. These results show the presence of antioxidant and normoglycaemic substances in aqueous macerated of Euphorbia hirta L.

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“…Three weak bands appearing in the low energy visible region at 15057 -15317, 17104 -17384 and 20755 -20982 cm -1 ranges may be attributed to the d-d transitions of the copper(II) ion in the square-pyramidal environment (C 4v ) [32]. In the square -pyramidal copper(II) complexes the plausible dorbital energy level scheme (idealized symmetry group C 4v ), is dx 2 [31,33,34]. This finding is further confirmed from the results of the ESR spectra.…”

Section: Ir Spectral Studies:-mentioning

confidence: 99%

Synthesis and Characterization of N3s2 Donors Macrocyclic Copper(ii) Complexes. Catechol Oxidase and Phenoxazinone Synthase Biomimetic Catalytic Activity.

Ramadan¹,

Shaban²,

Khalil³

et al. 2017

IJAR

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A new series of hexa-, and five-coordinated copper(II) complexes, having the molecular formulae of [CuLX]X H 2 O, 1, 2, 3 (X = Cl¯, Br¯, NO 3¯) and [CuL]X 2 nH 2 O, 4, 5 (X= AcO¯ and ClO 4¯) respectively and L is pentadentate pyridine based ligand have been synthesized. Structural characterization of these newly synthesized compounds was achieved by several physicochemical methods including elemental and thermal analysis (TGA and DTG), electrical molar conductance, magnetic moment measurements and spectral investigations such as IR, UV-Vis and ESR. The spectral and magnetic measurements in addition to the electrolytic conductance results demonstrated the octahedral and square-pyramidal stereochemistries for the hexa, and five coordinated copper(II) chelates respectively. Catechol oxidase and phenoxazinone synthase biomimetic catalytic activity of the inspected copper(II) chelates was studied and the results obtained indicated that, the catalytic reactivity is markedly depends on the structural properties of these newly synthesized copper(II) complexes. …………………………………………………………………………………………………….... Introduction:-Functional models of the metalloenzymes that activate molecular oxygen possess great potential as catalyst for specific oxidation reactions and as guides for the development of efficient small molecule catalysts [1]. Since, the oxidation of organic substrates with molecular oxygen under mild conditions is of great interest for industrial [2] and synthetic processes both from an economical and environmental [3] point of view, most of the focus of ongoing biomimetic and bioinspired synthetic approaches is on reproducing some structural and/or functional feature of the title enzymes. The synthesis and reactivity studies of transition metal complexes, as functional model compounds for metalloenzymes with oxidase activity, are of particular interest for the development of bioinspired catalysts for oxidation reactions.The potential role played by copper ions in the active sites of a large number of metalloproteins has stimulated efforts to design and characterize copper complexes as models for providing better understanding of biological systems and for assisting in the development of new homogeneous catalysts for selective oxidation. Particularly, the

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Synthesis, structure and spectral studies on mixed ligand copper(II) complexes of diimines and acetylacetonate

Cited by 40 publications

References 14 publications

New Bioactive Heteroleptic Copper(II) Carboxylates: Structure, Enzymatic and DNA-Binding Studies

New Bioactive Heteroleptic Copper(II) Carboxylates: Structure, Enzymatic and DNA-Binding Studies

Antioxidant and anti-hyperglycaemic activity of <i>Euphorbia hirta</i> L. on Wistar rats

Synthesis and Characterization of N3s2 Donors Macrocyclic Copper(ii) Complexes. Catechol Oxidase and Phenoxazinone Synthase Biomimetic Catalytic Activity.

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