Synthesis, structure, and reactions of (4-aryl-3-cyano-6-oxopiperidin-2-ylidene)malononitriles

New Reactions of 5-Amino-3-(Cyanomethyl)-1H-Pyrazole-4-Carbonitrile

“…In continuation of our studies on the chemistry of functionalized pyridines [15][16][17][18], we decided to prepare hybrid molecules bearing both nicotinonitrile and 3(50-aminopyrazole moieties. First, we prepared chloroacetamide 10 through reaction of 5-amino-3-(cyanomethyl)-1H-pyrazole-4carbonitrile 1 with chloroacetyl chloride (Scheme 2).…”

Synthesis of (3-Cyano-5,6,7,8-Tetrahydroquinolin-2(1H)-ylidene) Malononitriles

“…[4-Aryl-3-Cyano-5,6,7,8-Tetrahydroquinolin-2(1H)-ylidene]malononitriles (2) 2-Amino-4-arylbuta-1,3-diene-1,1,3-tricarbonitrile (0.5 g) was dissolved in hot absolute EtOH (15 mL). To the solution formed, an excess (0.35-0.4 mL) of freshly distilled 4-(1-cyclohexen-1-yl) morpholine was added.…”

“…Arylmethylidene derivatives of malononitrile dimer (AMDM) 1 are highly reactive Michael acceptors and are convenient and widely used synthetic reagents for constructing various heterocyclic systems [1]. A literature survey reveals the methods for the preparation of (pyridin-2(1H)-ylidene)malononitriles and (isoquinolin-3(2H)-ylidene) malononitriles [2,3]. However, there are no data on the preparation of quinolines by the reaction of AMDMs with enamines.…”

The Reaction of 5-Amino-3-(cyanomethyl)-1H-pyrazol-4-carbonitrile with beta-Cycloketols

“…In continuation of our studies in the chemistry of the malononitrile dimer [16][17][18][19], herein we report the reaction of 3-aryl-5-hydroxy-5-methyl-2,4-di (ethoxycarbonyl)cyclohexanones 1a,b with 5-amino-3-(cyanomethyl)-1H-pyrazole-4-carbonitrile 7 (Scheme 2). Aminopyrazole 7 can be easily prepared by the reaction of malononitrile dimer 8 with hydrazine hydrate [20].…”