Synthesis, Structure, and Biological Activities of 10‐Substituted 3,3,6,6‐Tetramethyl‐9‐Aryl‐3,4, 6,7,9,10‐hexahydroacridine‐1,8(2H,5H)‐dione Derivatives

Abstract

A series of 10‐substituted‐3,3,6,6‐tetramethyl‐9‐aryl‐3,4,6,7,9,10‐hexahydroacridine‐1,8(2H,5 H)‐dione derivatives 2 were synthesized by reaction of compounds 1 with amines. The compounds 1 were effectively prepared by 5,5‐dimethylcyclohexane‐1,3‐dione and aldehydes in the presence of a little amount of L‐proline as catalyst at room temperature. All the compounds were characterized by IR, MS, and 1H NMR. The crystal data of 1b and 2d were collected by X‐ray single‐crystal diffraction, and compounds 2b and 2d exhibited better inhibitory activity against HepG2 cells.

A biscationic imidazolium ionic liquid immobilized on graphene oxide as an efficient heterogeneous catalyst for the synthesis of tetraketone derivatives

“…26,27 They are also essential synthetic intermediates that can be used as precursors in the production of biologically and therapeutically active xanthene and polyhydroacridine derivatives. 28,29…”

Aluminized polyborate catalyzed efficient solvent-free synthesis of 1,8-dioxo-decahydroacridines via hantzsch condensation

“…They also find applications as an inhibitors of acetyl cholinesterase, fluorescent materials for visualization of biomolecules, dyes and in laser technologies. 3,4 They are also used as photo initiators, photo sensitizers and selective fluoride ion chemosensor. 5 They also finds application in treatment of Alzheimer's disease due to their platelet antiaggregatory activity.…”