Synthesis, structure analysis, DFT calculations and energy frameworks of new coumarin appended oxadiazoles, to regress ascites malignancy by targeting VEGF mediated angiogenesis

Jyothi, Mahima; Banumathi,; Zabiulla,; Sherapura, Ankith; Khamees, Hussien Ahmed; Prabhakar, B.T.; Khanum, Shaukath Ara

doi:10.1016/j.molstruc.2021.132173

Cited by 7 publications

(5 citation statements)

References 76 publications

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“…Jyothi and colleagues [ 106 ] synthesized coumarin quinoline derivatives 148a – c ( Figure 25 ) ( Table 10 ) and evaluated their activities against the human-derived cancer cells ACHN, A375, SIHA, Skov3, EAC, and NIH3T3. However, compounds 148a – c did not demonstrate any anticancer activity.…”

Section: Pharmacological Activitiesmentioning

confidence: 99%

Application of Quinoline Ring in Structural Modification of Natural Products

Zhao,

Li,

Guo

et al. 2023

Molecules

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Natural compounds are rich in pharmacological properties that are a hot topic in pharmaceutical research. The quinoline ring plays important roles in many biological processes in heterocycles. Many pharmacological compounds, including saquinavir and chloroquine, have been marketed as quinoline molecules with good anti-viral and anti-parasitic properties. Therefore, in this review, we summarize the medicinal chemistry of quinoline-modified natural product quinoline derivatives that were developed by several research teams in the past 10 years and find that these compounds have inhibitory effects on bacteria, viruses, parasites, inflammation, cancer, Alzheimer’s disease, and others.

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Section: Pharmacological Activitiesmentioning

confidence: 99%

Application of Quinoline Ring in Structural Modification of Natural Products

Zhao,

Li,

Guo

et al. 2023

Molecules

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“…T he results showed that compound 22 ( Figure 2 ) exhibited antiproliferative effects on EAC and Skov3 cell lines with IC 50 values of 10.2 and 9.5 μM compared with the standard 5-Fluorouracil. In addition, studies have shown that compound 22 has a targeting effect on VEGF and can significantly inhibit the growth of ascites tumours, so it is a promising anticancer molecule 30 .…”

Section: Oxadiazolementioning

confidence: 99%

Research progress on the synthesis and pharmacology of 1,3,4-oxadiazole and 1,2,4-oxadiazole derivatives: a mini review

Wang

Sun

Jia

et al. 2022

Journal of Enzyme Inhibition and Medicinal Chemistry

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Oxadiazole is a five-membered heterocyclic compound containing two nitrogen atoms and one oxygen atom. The 1,3,4-oxadiazole and 1,2,4-oxadiazole have favourable physical, chemical, and pharmacokinetic properties, which significantly increase their pharmacological activity via hydrogen bond interactions with biomacromolecules. In recent years, oxadiazole has been demonstrated to be the biologically active unit in a number of compounds. Oxadiazole derivatives exhibit antibacterial, anti-inflammatory, anti-tuberculous, anti-fungal, anti-diabetic and anticancer activities. In this paper, we report a series of compounds containing oxadiazole rings that have been published in the last three years only (2020–2022) as there was no report or their activities described in any article in 2019, which will be useful to scientists in research fields of organic synthesis, medicinal chemistry, and pharmacology.

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“…It is well known that the key element of probe design is the ability of an excellently chosen uorophore to combine with the detection group for speci c recognition. Coumarin dyes are widely used in uorescent probes because of their low biotoxicity, high uorescence sensitivity, good photostability and easy modi cation of the main chain [22][23][24][25][26][27][28][29][30] . Coumarin derivatives can also be used as uorescence markers or imaging agents to identify tumor lesions and study the subcellular localization of drugs [31][32][33][34][35][36][37][38][39][40][41][42] .…”

Section: Introductionmentioning

confidence: 99%

Two Novel coumarin-based fluorescent probes for the detection of Cu2+ and biological applications

Zhang

Huang

Wang

et al. 2023

Preprint

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Large accumulations of copper (Cu) ions in the human body may cause damage, including organ and brain damage. In recent years, studies have proven that a large accumulation of Cu ions can lead to Parkinson's disease and Alzheimer's disease, therefore it is great important to develop novel strategies for detecting trace Cu in environmental and biological samples. In this work, we designed two new coumarin-based colorimetric and fluorescent probes HQ1 and HQ2. These two probes could selectively respond to Cu2+ with obvious color and fluorescence changes, and the presence of other metal ions had no effect on these changes. The two probes also exhibited high sensitivity for Cu2+, with a detection limit as low as 1.81×10-8 M/ 1.57×10-8 M. Notably, the two probes showed potential practical applications and were successfully used for detecting Cu2+ in a test strip, A549 cells and living zebrafish larvae.

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Synthesis, structure analysis, DFT calculations and energy frameworks of new coumarin appended oxadiazoles, to regress ascites malignancy by targeting VEGF mediated angiogenesis

Cited by 7 publications

References 76 publications

Application of Quinoline Ring in Structural Modification of Natural Products

Application of Quinoline Ring in Structural Modification of Natural Products

Research progress on the synthesis and pharmacology of 1,3,4-oxadiazole and 1,2,4-oxadiazole derivatives: a mini review

Two Novel coumarin-based fluorescent probes for the detection of Cu2+ and biological applications

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