Synthesis, structure–activity relationships and biological evaluation of dehydroandrographolide and andrographolide derivatives as novel anti-hepatitis B virus agents

Chen, Hao; Ma, Yun‐Bao; Huang, Xiaoyan; Geng, Chang‐An; Zhao, Yong; Wang, Lijun; Guo, Ruihua; Liang, Wen-Juan; Zhang, Xuemei

doi:10.1016/j.bmcl.2014.03.060

Cited by 92 publications

(61 citation statements)

References 36 publications

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“…The results suggest that andrographolide exerts its activity at a post entry step, and effectively inhibits viral genome replication. Several previous studies have shown that andrographolide possesses anti-cancer 30 31 , anti-metastasis 32 , anti-inflammatory 33 , anti-bacterial 34 and antiviral 35 36 37 38 39 40 41 42 43 activities. Andrographolide has been shown to exert activity on a wide range of viruses including human papillomavirus pseudovirus 38 , Influenza A virus 37 43 , hepatitis B virus 36 hepatitis C virus 39 , herpes simplex virus 41 42 and human immunodeficiency virus 35 40 .…”

Section: Discussionmentioning

confidence: 99%

Activity of andrographolide against chikungunya virus infection

Wintachai

Kaur

Lee

et al. 2015

Sci Rep

118

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Chikungunya virus (CHIKV) is a re-emerging mosquito-borne alphavirus that has recently engendered large epidemics around the world. There is no specific antiviral for treatment of patients infected with CHIKV, and development of compounds with significant anti-CHIKV activity that can be further developed to a practical therapy is urgently required. Andrographolide is derived from Andrographis paniculata, a herb traditionally used to treat a number of conditions including infections. This study sought to determine the potential of andrographolide as an inhibitor of CHIKV infection. Andrographolide showed good inhibition of CHIKV infection and reduced virus production by approximately 3log10 with a 50% effective concentration (EC50) of 77 μM without cytotoxicity. Time-of-addition and RNA transfection studies showed that andrographolide affected CHIKV replication and the activity of andrographolide was shown to be cell type independent. This study suggests that andrographolide has the potential to be developed further as an anti-CHIKV therapeutic agent.

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Section: Discussionmentioning

confidence: 99%

Activity of andrographolide against chikungunya virus infection

Wintachai

Kaur

Lee

et al. 2015

Sci Rep

118

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“…Chen et al. found that dehydroandrographolide and andrographolide, two natural diterpenoids isolated from A. paniculata, possessed activity against hepatitis B virus DNA replication . Luo et al.…”

Section: Discussionmentioning

confidence: 99%

Successful treatment of plantar warts using topical Zijinding, a traditional Chinese medicine preparation: A case series

Zhao

Sridhar

Guo

et al. 2019

J of Cosmetic Dermatology

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Introduction Plantar warts are associated with high transmissibility and morbidity. Among the available therapeutic options, none is uniformly effective or virucidal. Salicylic acid is the first‐line therapy but approximately one‐third of lesions could not resolve and become recalcitrant despite repeated treatment. Cryotherapy is widely accessible with low cost but may be complicated by pain, blister formation, hemorrhage, infection, excessive granulation tissue formation, and hyper‐/hypo‐pigmentation. Hence, alternative treatment modalities are essential. Methods Three patients with debilitating plantar warts refractory or intolerant to cryotherapy were treated with a course of Zijinding (a traditional Chinese medicine preparation) paste prepared with white vinegar. Results All three patients showed excellent clinical response with Zijinding application with evolution of lesions to scabs and subsequently healthy skin within 1.5 to 5 months of treatment. Treatment was well tolerated and had no significant side effects with excellent compliance recorded for all three patients. There was no relapse for at least 10 months after stopping the treatment. Conclusion Topical Zijinding could be a promising alternative modality for the treatment of plantar warts. Further clinical trials on the comparison of Zijinding and other treatment modalities of plantar warts are warranted. Further studies are required to investigate the mechanism of action of Zijinding and to isolate the active ingredient.

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“…According to molecular hybridization principle of medicinal chemistry, they designed and synthesized 48 derivatives of dehydroandrographolide and andrographolide, and evaluated for their anti-HBV activity. Among these, compound 56 ( Figure 12) has the best bioactivity with an IC 50 value of 10.3 μM [141].…”

Section: Inhibitors Of Viral Dna Synthesismentioning

confidence: 98%

Recent Advance of the Hepatitis B Virus Inhibitors: A Medicinal Chemistry Overview

et al. 2015

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Hepatitis B Virus (HBV) is one of the most prevalent viral infections of human worldwide. The therapies are limited in the clinical context because of negative side effects of interferons and the development of viral resistance to the nucleoside/nucleotide inhibitors. In this review, we summarize the recent advances in design and development of potent anti-HBV inhibitors from natural sources and synthetic compounds, targeting different steps in the life cycle of HBV. We attempt to emphasize the major structural modifications, mechanisms of action and computer-aided docking analysis of novel potent inhibitors that need to be addressed in the future to design potent anti-HBV molecules.

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Synthesis, structure–activity relationships and biological evaluation of dehydroandrographolide and andrographolide derivatives as novel anti-hepatitis B virus agents

Cited by 92 publications

References 36 publications

Activity of andrographolide against chikungunya virus infection

Activity of andrographolide against chikungunya virus infection

Successful treatment of plantar warts using topical Zijinding, a traditional Chinese medicine preparation: A case series

Recent Advance of the Hepatitis B Virus Inhibitors: A Medicinal Chemistry Overview

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