Activity of andrographolide against chikungunya virus infection

Wintachai, Phitchayapak; Kaur, Parvinder; Lee, Regina Ching Hua; Ramphan, Suwipa; Kuadkitkan, Atichat; Wikan, Nitwara; Ubol, Sukathida; Roytrakul, Sittiruk; Chu, Justin Jang Hann; Smith, Duncan R.

doi:10.1038/srep14179

Cited by 120 publications

(96 citation statements)

References 57 publications

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“…The plant compound has been evidenced to have anti-inflammatory, anti-cancer, anti-obesity and anti-diabetes (Dai et al, 2019). Andrographolide was found to have antiviral properties over many types of viral infections (Gupta et al, 2017) and was found to have activity against Chikungunya (Wintachai et al, 2015) potential inhibitor of herpes simplex virus type-1 (Seubsasana et al, 2011). Also, during the outbreak of dengue in India at 2006, aqueous extracts of Andgrographis paniculata were given through the advice of Ministry of AYUSH (Ayurveda, Unani, Siddha and Homeopathy) department of India which led to decrease in cases and infection of the disease as a preventive measure even to normal people acting as a immune booster.…”

Section: Introductionmentioning

confidence: 99%

Andrographolide as a potential inhibitor of SARS-CoV-2 main protease: an in silico approach

Enmozhi

Raja

Sebastine³

et al. 2020

Journal of Biomolecular Structure and Dynamics

332

290

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SARS-CoV-2 virus which caused the global pandemic the Coronavirus Disease-2019 (COVID-2019) has infected about 1,203,959 patients and brought forth death rate about 64,788 among 206 countries as mentioned by WHO in the month of April 2020. The clinical trials are underway for Remdesivir, an investigational anti-viral drug from Gilead Sciences. Antimalarial drugs such as Chloroquine and Hydroxychloroquine derivatives are being used in emergency cases; however, they are not suitable for patients with conditions like diabetes, hypertension and cardiac issues. The lack of availability of approved treatment for this disease calls forth the scientific community to find novel compounds with the ability to treat it. This paper evaluates the compound Andrographolide from Andrographis paniculata as a potential inhibitor of the main protease of SARS-COV-2 (Mpro) through in silico studies such as molecular docking, target analysis, toxicity prediction and ADME prediction. Andrographolide was docked successfully in the binding site of SARS-CoV-2 Mpro. Computational approaches also predicts this molecule to have good solubility, pharmacodynamics property and target accuracy. This molecule also obeys Lipinski's rule, which makes it a promising compound to pursue further biochemical and cell based assays to explore its potential for use against COVID-19. ARTICLE HISTORY

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Section: Introductionmentioning

confidence: 99%

Andrographolide as a potential inhibitor of SARS-CoV-2 main protease: an in silico approach

Enmozhi

Raja

Sebastine³

et al. 2020

Journal of Biomolecular Structure and Dynamics

332

290

View full text Add to dashboard Cite

show abstract

“…Traditional Chinese herbs are gaining increasing attention as a source of anticancer agents, particularly as they are easy to obtain and have few, if any, side effects (24). Previous studies have demonstrated that ANDRO possesses anti-inflammatory (25,26), anti-asthmatic (27), anti-viral (28) and hepatoprotective (29) activities, in addition to its various anticancer effects (30,31). However, the effect of ANDRO on mutant p53 has not previously been investigated.…”

Section: Discussionmentioning

confidence: 99%

Andrographolide induces degradation of mutant p53 via activation of Hsp70

et al. 2018

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The tumor suppressor gene p53 encodes a transcription factor that regulates various cellular functions, including DNA repair, apoptosis and cell cycle progression. Approximately half of all human cancers carry mutations in p53 that lead to loss of tumor suppressor function or gain of functions that promote the cancer phenotype. Thus, targeting mutant p53 as an anticancer therapy has attracted considerable attention. In the current study, a small-molecule screen identified andrographlide (ANDRO) as a mutant p53 suppressor. The effects of ANDRO, a small molecule isolated from the Chinese herb Andrographis paniculata, on tumor cells carrying wild-type or mutant p53 were examined. ANDRO suppressed expression of mutant p53, induced expression of the cyclin-dependent kinase inhibitor p21 and pro-apoptotic proteins genes, and inhibited the growth of cancer cells harboring mutant p53. ANDRO also induced expression of the heat-shock protein (Hsp70) and increased binding between Hsp70 and mutant p53 protein, thus promoting proteasomal degradation of p53. These results provide novel insights into the mechanisms regulating the function of mutant p53 and suggest that activation of Hsp70 may be a new strategy for the treatment of cancers harboring mutant p53.

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“…Recently, effects of andrographolide on virus infection have also been reported. Wintachai et al (15), reported that andrographolide could significantly alleviate chikungunya virus infection by inhibiting or stimulating a variety of targets. In the present study of cervical carcinoma, Ekalaksananan et al (16), found that andrographolide and its derivatives inhibited HPV16 pseudovirus infection by inhibiting the expression of viral oncogene.…”

Section: Discussionmentioning

confidence: 99%

Andrographolide attenuates viral myocarditis through interactions with the IL‑10/STAT3 and P13K/AKT/NF‑κβ signaling pathways

Zhao¹,

Wang

et al. 2018

Exp Ther Med

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As a cardiac disease caused by the inflammation of the heart muscle, viral myocarditis (VMC) causes dilated cardiomyopathy, congestive heart failure and even death. With anti-inflammatory activities, andrographolide has been used in the treatment of various human diseases. In the present study, therapeutic effects of andrographolide on VMC were investigated using a VMC mouse model. Measurement of physiological indexes and echocardiographic examination was performed to explore the effects of andrographolide on cardiac function in mice with VMC. Levels of TNF-α, hs-CRP and cTnl in serum were measured by enzyme-linked immunosorbent assay (ELISA). Effects of andrographolide on the expression of L-10, STAT3, NF-κβ p65 and NF-κβ p50 were investigated by western blot analysis. Results indicated that andrographolide treatment reduced serum levels of TNF-α, hs-CRP and cTnl, increased the expression levels of IL-10 and STAT3 and reduced the expression levels of NF-κβ p65 and NF-κβ p50 and the phosphorylation levels of phosphoinositide 3-kinase (P13K) and AKT in the heart tissues of mice with VMC. In addition, andrographolide also increased the expression level of Iκβα in heart tissue. Therefore, it was concluded that andrographolide may inhibit the progression of VMC by interacting with the IL-10/STAT3 and NF-κβ signaling pathways.

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Activity of andrographolide against chikungunya virus infection

Cited by 120 publications

References 57 publications

Andrographolide as a potential inhibitor of SARS-CoV-2 main protease: an in silico approach

Andrographolide as a potential inhibitor of SARS-CoV-2 main protease: an in silico approach

Andrographolide induces degradation of mutant p53 via activation of Hsp70

Andrographolide attenuates viral myocarditis through interactions with the IL‑10/STAT3 and P13K/AKT/NF‑κβ signaling pathways

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