Synthesis, structural insights, and biological screening of DNA targeted Ru(ii)(η⁶-p-cymene) complexes containing bioactive amino-benzothiazole ligand scaffolds

Abstract

Two new ruthenium-based drug candidates [Ru(p-cymene)(C7H4ClN2S)Cl2] (1) and [Ru(p-cymene)(C7H5FN2S)Cl2] (2) containing amino benzothiazole ligands, were synthesized and comprehensively characterised by multi-spectroscopic and single crystal X-ray diffraction technique. B3LYP computations were...

Water soluble transition metal [Ni(ii), Cu(ii) and Zn(ii)] complexes of N-phthaloylglycinate bis(1,2-diaminocyclohexane). DNA binding, pBR322 cleavage and cytotoxicity

“…12). There is a clear indication of cleavage inhibition upon the addition of EtOH (lane 2), NaN3 (lane 5) and DMSO (lane 7), therefore validating the oxidative cleavage mechanism by the Cu( ii ) complex in which the ROS (reactive oxygen species), singlet oxygen species (O 2 ) and hydroxyl radicals (˙OH) were involved in plasmid nuclease activity 63 (Scheme 2). However, in the cases of Zn( ii ) and Ni( ii ), there was a significant inhibition of cleavage only with EtOH (lane 2) and DMSO (lane 7) which suggested hydrolytic cleavage in which the hydroxyl radicals (˙OH) trigger the activation of the phosphodiester backbone of DNA during the cleavage process.…”

Ru(II)(ƞ6-p-cymene) Conjugates Loaded onto Graphene Oxide: An Effective pH-Responsive Anticancer Drug Delivery System

“…Two ruthenium-based drug conjugates were synthesized by methods previously reported by our group [ 23 ]. Both of the complexes were encapsulated on graphene oxide by ultrasonication.…”

“…MCF7, MDA-MB-231, and HeLa, in terms of the GI 50 by SRB assay ( Figure 17 , Tables S2 and S3 ). Earlier, the cytotoxic activity of NCD 1 and NCD 2 was carried out against the same cancer cell lines, and both the complexes showed moderate cytotoxicity, which could be due to the better hydrophobic interaction of the p -cymene moiety of the metal complexes with the cell membrane [ 23 ]. Moderate cytotoxicity of ruthenium complexes has been previously reported in the literature by Ivanović et al for the [( η 6- p -cymene)RuCl(picolinic acid)]H 2 O complex with an IC 50 equal to 81.97 μM.…”