Synthesis, structural, electrochemical, DNA interaction, antimicrobial and molecular docking studies on dimeric copper(II) complexes involving some potential bidentate ligands

Jayamani, Arumugam; Sengottuvelan, Nallathambi; Chakkaravarthi, G.

doi:10.1016/j.poly.2014.05.076

Cited by 43 publications

(18 citation statements)

References 70 publications

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“…The strong coordinating properties of 2-hydroxy-benzaldehyde (salicylaldehyde) and its complexes with 3d transition metals have stimulated research on these compounds that find applications in both pure [19,20] and applied chemistry [21,22]. It has also been shown that these ligands possess antimicrobial properties [23,24]. These ligands coordinate mainly in a bidentate manner with transition metals in the mono-anionic form, adopting geometries from square-planar [25] to square-pyramidal [26] and octahedral [27].…”

mentioning

confidence: 99%

Cadmium(II) complexes of 5-nitro-salicylaldehyde and α-diimines: synthesis, structure and interaction with calf-thymus DNA

Zianna

Šumar-Ristović

Psomas

et al. 2015

Journal of Coordination Chemistry

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complexes of 5-nitro-salicylaldehyde and α-diimines: Synthesis, structure and interaction with calf-thymus DNA, Journal of Coordination Chemistry, Five Cd(II) complexes with the anion of 5-NO 2 -salicylaldehydeH (5-NO 2 -saloH) in the absence or presence of the α-diimine 1,10-phenanthroline (phen), 2,2'-dipyridylamine (dpamH), 2,2'-dipyridine (bipy) or 2,9-dimethyl-1,10-phenanthroline (neoc) were synthesized and characterized as (2), [Cd(5-NO 2 -salo) 2 (dpamΗ)] (3), [Cd 3 (5-NO 2 -salo) 6 (bipy) 2 ] (4) and [Cd(5-NO 2salo)(neoc)(NO 3 )] 2 (5). Based on spectroscopic results (IR, UV, NMR), elemental analysis and conductivity measurements an octahedral geometry around cadmium metal ion is suggested, with the 5-NO 2 -salicylaldehyde ligand having different coordination modes. The structures determined by X-ray crystallography verified neutral mononuclear 1-3 and trinuclear 4.Simultaneous TG/DTG-DTA technique was used to analyze the thermal behavior of 1, 2 and 3.The complexes bind tightly to calf-thymus DNA mainly by intercalation, as concluded by DNAviscosity measurements and exhibit significant displacement of EB from the EB-DNA complex.

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mentioning

confidence: 99%

Cadmium(II) complexes of 5-nitro-salicylaldehyde and α-diimines: synthesis, structure and interaction with calf-thymus DNA

Zianna

Šumar-Ristović

Psomas

et al. 2015

Journal of Coordination Chemistry

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“…B. subtilis showed highest susceptibility against MPH3, MPH4 and MPH5 with zone of inhibition 15±0.1 mm. the complexes MPH3, MPH4 and MPH5 showed a significant antibacterial activity against E. coli with zone of inhibition 12±0.3 mm (29). In case of antifungal activity, the highest activity was observed in MPH2 against C. neoformans with 10±0.6 mm zone of inhibition.…”

Section: Antimicrobial Activitymentioning

confidence: 94%

Synthesis of Chlorotoxin by Native Chemical Ligation

Tcm

Parameshwara²,

Venkatesh³

et al. 2018

Journal of the Turkish Chemical Society Section A: Chemistry

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Complexes of nickel(II), cobalt(II), copper(II), zinc(II), and manganese(II) are derived from the ligand, (N-(3-methoxyphenyl)-2-[(2E)-3-phenylprop-2-enoyl]hydrazinecarboxamide [MPH] and structurally characterized by various physicochemical and spectral tools such as FTIR, UV-Visible, 1 H NMR, LC-Mass, P-XRD and TGA-DTC. These studies showed that the ligand coordinated to the 3d metal ions in bidentate manner. X-ray diffraction studies indicates that the Ni(II), Cu(II) and Zn(II) complexes are crystalline in nature. Degradation mechanisms, thermodynamic and kinetic parameters of the synthesized metal complexes have been evaluated. The prepared ligand and complexes were evaluated for in-vitro antioxidant DPPH assay, in which metal complexes showed excellent activity. The molecular docking analysis by using human antioxidant enzyme DTT (PDB: 3MNG) have also been evaluated. The ligand and their metal complexes were screened for their antimicrobial activities against different pathogenic bacterial and fungal species.

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“…On the other hand, Co(II) complex showed promising activity towards gram-negative bacterial strains of P. aeruginosa and B. subtilis. While the ligand AF and Zn(II) showed the least activity towards all the bacterial strains (29,30).…”

Section: Biological Studies Antibacterial Activitymentioning

confidence: 99%

Spectral, DFT, molecular docking and antibacterial activity studies of Schiff base derived from furan-2-carbaldehyde and their metal(II) complexes

Manjuraj

Tcm

Jayanna³

et al. 2020

Journal of the Turkish Chemical Society Section A: Chemistry

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Metal(II) complexes of cobalt(II) (1), copper(II) (2), nickel(II) (3), and zinc(II) (4) with Schiff base ligand derived from furan-2-carbaldehyde were synthesized and elucidated by IR, electronic, mass, 1 H NMR, and magnetic susceptibility measurements. Using DFT-based optimization of structures, bond length, bond angle, HOMO-LUMO energy gaps, and molecular electrostatic potential maps (MEP) of ligand and complexes 1-3 were theoretically calculated at the B3LYP/LANL2DZ level of theory. HOMO-LUMO energy gap was calculated which allowed the calculation of comparable properties like chemical hardness, chemical inertness, and chemical potential. The Ni(II) and Cu(II) complexes showed potent inhibition against all the bacterial strains. In comparison with antibacterial activity, molecular docking studies were carried out with protein receptor SEC2 (PDB: 1STE) in Staphylococcus aureus.

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Synthesis, structural, electrochemical, DNA interaction, antimicrobial and molecular docking studies on dimeric copper(II) complexes involving some potential bidentate ligands

Cited by 43 publications

References 70 publications

Cadmium(II) complexes of 5-nitro-salicylaldehyde and α-diimines: synthesis, structure and interaction with calf-thymus DNA

Cadmium(II) complexes of 5-nitro-salicylaldehyde and α-diimines: synthesis, structure and interaction with calf-thymus DNA

Synthesis of Chlorotoxin by Native Chemical Ligation

Spectral, DFT, molecular docking and antibacterial activity studies of Schiff base derived from furan-2-carbaldehyde and their metal(II) complexes

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