2016
DOI: 10.1016/j.molliq.2016.05.047
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Synthesis, structural characterization, X-ray, solvatochromism and biological properties of 7-hydroxy-2-(2-hydroxy-5-(phenyldiazenyl)benzylidene)amino)-4-phenyl-4H-chromene-3-carbonitrile

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Cited by 11 publications
(5 citation statements)
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“…[1][2][3] Chromenes demonstrate a diverse range of biological activities, such as anti-anaphylactic activity, antimicrobial, anticancer properties, diuretic, and spasmolytic, and are also used to synthesize tacrine analogs and the blood anticoagulant warfarin. 4,5 Chromene derivatives also form components of many natural products such as calanolides, calophyllolide, and calanone. 6 In addition, pyrano [3,2-c]chromenes exhibit a wide range of biological activities, including against Alzheimer's disease, schizophrenia, and AIDS-associated dementia, making them valuable synthons for the synthesis of pharmacological agents.…”
Section: Introductionmentioning
confidence: 99%
“…[1][2][3] Chromenes demonstrate a diverse range of biological activities, such as anti-anaphylactic activity, antimicrobial, anticancer properties, diuretic, and spasmolytic, and are also used to synthesize tacrine analogs and the blood anticoagulant warfarin. 4,5 Chromene derivatives also form components of many natural products such as calanolides, calophyllolide, and calanone. 6 In addition, pyrano [3,2-c]chromenes exhibit a wide range of biological activities, including against Alzheimer's disease, schizophrenia, and AIDS-associated dementia, making them valuable synthons for the synthesis of pharmacological agents.…”
Section: Introductionmentioning
confidence: 99%
“…[15,16] Chromene derivatives have displayed a wide range of biological activities such as antibacterial, antifungal, anti-influenza, antimalarial, anticoagulant, antitumor, anticancer, and anti-HIV. [17][18][19] Hence, design and synthesis of pharmacophores in medicinal chemistry and drug development could be performed by modeling chromene-like structure found in plant. [20] Also, chromenes included 3-substituted coumarin, 3-substituted indole, β-naphthol, and indandion derivatives are found in some natural and medicinal compounds, while there are very few papers for their synthesis.…”
Section: Introductionmentioning
confidence: 99%
“…Therefore, for synthetic organic chemists, these compounds are capable of functioning as both starting and intermediate material in many chemical reactions. For instance, 2‐(4‐nitrobenzylidene)malononitrile and 2‐(3,4,5‐trimethoxybenzylidene)malononitrile are well known as potent tyrosine kinase inhibitors, and 2‐amino‐7‐hydroxy‐4‐phenyl‐4H‐chromene‐3‐carbonitrile exhibits activity against the gram‐positive bacteria Bacillus cereus, Staphylococcus aureus and Staphylococcus epidermidis …”
Section: Introductionmentioning
confidence: 99%