Synthesis, structural characteristics, DNA binding properties and cytotoxicity studies of a series of Ru(III) complexes

Tan, Cai‐Ping; Liu, Jie; Chen, Lanmei; Shi, Shuo; Ji, Liang‐Nian

doi:10.1016/j.jinorgbio.2008.03.005

Cited by 197 publications

(53 citation statements)

References 72 publications

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“…The results were compared with the experimental photophysical and electrochemical data, antimicrobial activity and photocleavage of pBR322 DNA of complexes 1-3, also investigated cytotoxicity, apoptosis and cell cycle arrest against selected cancer cell lines by flow cytometry. All these experiments showed that the complexes 1-3 exhibit efficient activity in a dose-dependent manner [26][27][28][29].…”

Section: Introductionmentioning

confidence: 91%

Synthesis, Spectral Properties and DFT Calculations of new Ruthenium (II) Polypyridyl Complexes; DNA Binding Affinity and in Vitro Cytotoxicity Activity

et al. 2017

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In this paper a novel ligand debip (2-(4-N,N-diethylbenzenamine)1H-imidazo[4,5-f] [1, 10]phenanthroline) and its Ru(II) polypyridyl complexes [Ru(L)(debip)], (L = phen (1), bpy (2) and dmb (3)) have been synthesized and characterized by spectroscopic techniques. The DNA binding studies for all these complexes were examined by absorption, emission, quenching studies, viscosity measurements and cyclic voltammetry. The light switching properties of complexes 1-3 have been evaluated. Molecular docking, Density Functional Theory (DFT) and time dependent DFT calculations were performed. The Ru(II) complexes exhibited efficient photocleavage activity against pBR322 DNA upon irradiation and exhibited good antimicrobial activity. Also investigated 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) reduction assay, lactate dehydrogenase (LDH) release assay and reactive oxygen species (ROS) against selected cancer cell lines (HeLa, PC3, Lancap, MCF-7 and MD-MBA 231).

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Section: Introductionmentioning

confidence: 91%

Synthesis, Spectral Properties and DFT Calculations of new Ruthenium (II) Polypyridyl Complexes; DNA Binding Affinity and in Vitro Cytotoxicity Activity

et al. 2017

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“…In recent years, many research have been focused on the interaction of small molecules with DNA (Song et al 2006;Kožurková et al 2008;Tan et al 2008). DNA is generally the primary intracellular target of anticancer drugs, because the interaction between small molecules and DNA can cause DNA damage in cancer cells, blocking the division of cancer cells and resulting in cell death (Zuber et al 1998;Hecht 2000;Sastry and Patel 1993).…”

Section: Introductionmentioning

confidence: 99%

From GC-rich DNA binding to the repression of survivin gene for quercetin nickel (II) complex: implications for cancer therapy

2010

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The DNA binding and cleavage properties of quercetin nickel (II) complex have been studied, but little attention has been devoted to the relationship between antitumor activity of this complex and DNA-binding properties. In the present study, we report that quercetin nickel (II) complex showed significant cytotoxicity against three tumor cell lines (HepG2, SMMC7721 and A549). Hoechst33258 and AO/EB staining showed HepG2 cells underwent the typical morphologic changes of apoptosis characterized by nuclear shrinkage, chromatin condensation, or fragmentation after exposure to quercetin nickel (II) complex. We also demonstrate that the levels of survivin and bcl-2 protein expression in HepG2 cells decreased concurrently, and the levels of p53 protein increased significantly after treatment with quercetin nickel (II) complex by immunocytochemistry analysis. The relative activity of caspase-3 and caspase-9 increased significantly after treatment with the complex. Furthermore, fluorescence measurements and molecular modeling were performed to learn that the complex could be preferentially bound to DNA in GC region. These results imply that quercetin nickel (II) complex may intercalate into the GC-rich core promoter region of survivin, down-regulating survivin gene expression and promoting tumor cells apoptosis. So our results suggest that antitumor activity of quercetin nickel (II) complex might be related to its intercalation into DNA and DNA-binding selectivity, and that the complex may be a promising agent for cancer therapy.

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“…The titrations were performed for complexes (1)(2)(3)(4)(5) and the control ethidium bromide (0.2-1.0×10 -5 M). Each compound was introduced into the CT DNA solution and the average flow time was observed for each resulting mixture during the viscosity titration [17] . The viscosity of CT DNA increased with rising ratio of complexes (1)(2)(3)(4)(5) , where η is the specific viscosity of DNA in the presence of the complex and η 0 is the specific viscosity of DNA alone; t complex , t DNA and t 0 are the average flow time for the DNA in the presence of the complex, DNA alone and Tris-HCl buffer, respectively [18] .…”

Section: Viscosity Titration Measurementsmentioning

confidence: 99%

Antimicrobial, Antioxidant and DNA Interaction Studies of Water-soluble Complexes of Schiff Base Bearing Morpholine Moiety

Sakthikumar¹,

Raja²,

Sankarganesh³

et al. 2018

pharmaceutical-sciences

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Synthesis, structural characteristics, DNA binding properties and cytotoxicity studies of a series of Ru(III) complexes

Cited by 197 publications

References 72 publications

Synthesis, Spectral Properties and DFT Calculations of new Ruthenium (II) Polypyridyl Complexes; DNA Binding Affinity and in Vitro Cytotoxicity Activity

Synthesis, Spectral Properties and DFT Calculations of new Ruthenium (II) Polypyridyl Complexes; DNA Binding Affinity and in Vitro Cytotoxicity Activity

From GC-rich DNA binding to the repression of survivin gene for quercetin nickel (II) complex: implications for cancer therapy

Antimicrobial, Antioxidant and DNA Interaction Studies of Water-soluble Complexes of Schiff Base Bearing Morpholine Moiety

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