Synthesis, spectroscopic, thermogravimetric and antimicrobial studies of mixed ligands complexes

Mahmoud, Walaa H.; Mahmoud, Nessma F.; El‐Sonbati, A.Z.; El-Bindary, A.A.

doi:10.1016/j.molstruc.2015.04.004

Cited by 44 publications

(33 citation statements)

References 49 publications

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“…The significant increase in the antimicrobial efficiency of modified PVC in presence of AgNPs may be due to the ability of Ag to penetrate the cell causing damage through its binding to the thiol groups (SH) exists in enzymes of microorganisms and subsequently leads to deactivation of enzymes .…”

Section: Resultsmentioning

confidence: 99%

Thiazole derivatives‐functionalized polyvinyl chloride nanocomposites with photostability and antimicrobial properties

Gaballah

Khalil

Rabie

2018

Vinyl Additive Technology

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Polyvinyl chloride (PVC) was modified via substitution reaction with 2-aminothiazole and ethyl 2-aminothiazole-4-carboxylate separately in the absence and in presence of silver (AgNPs) or copper (CuNPs) nanoparticles, using metal salts as precursors, in 3% (w/w) with respect to PVC. The functionalized PVCnanocomposites have been characterized via FTIR, 1 HNMR spectroscopic analyses, in addition to the morphological investigation such as scanning (SEM) and transmission electron microscopy (TEM). Spectral data confirmed the introduction of the thiazole (ester) to the PVC backbone. TEM analysis showed that the sizes of the AgNPs and CuNPs have fallen in the range of 10-30 nm and 30-50 nm for the prepared nanocomposites, respectively. Evaluating the photostability of modified nanocomposites was estimated by following the extent of discoloration for UV-irradiated samples colorimetrically in accordance with the irradiation time. The antimicrobial activity of the modified nanocomposites was explored against three Gram+ve bacteria (Bacillus subtilis, Staphylococcus aureus, and Streptococcus faecalis), three Gram-ve bacteria (Escherichia coli, Neisseria gonorrhoeae, and Pseudomonas aeruginosa), and two fungi (Candida albicans and Aspergillus flavus). Aminothiazole (ester)-functionalized PVC exhibited significant antimicrobial efficiencies against the investigated pathogens. However, incorporation of AgNPs or CuNPs to the modified PVC enhanced their inhibitory effect against the microorganisms under investigation. J. VINYL ADDIT. TECHNOL., 25:E137-E146, 2019.

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Section: Resultsmentioning

confidence: 99%

Thiazole derivatives‐functionalized polyvinyl chloride nanocomposites with photostability and antimicrobial properties

Gaballah

Khalil

Rabie

2018

Vinyl Additive Technology

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“…The conductance data indicates that some of the metal complexes are having conductivity values in accordance with electrolytes [8][9][10].…”

Section: Molar Conductivity Measurementsmentioning

confidence: 99%

Ternary metal complexes of guaifenesin drug: Synthesis, spectroscopic characterization and in vitro anticancer activity of the metal complexes

Mahmoud

El‐Sonbati

et al. 2015

Spectrochimica Acta Part A: Molecular and Biomolecular Spectros

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“…The thermal stability of the HL ligand and its metal complexes was investigated using TG and DTG under nitrogen atmosphere with a heating rate of 10°C/min from ambient temperature up to 1000°C to decide whether the water molecules (if present) are inside or outside the inner coordination sphere of the central metal ion (Table ) …”

Section: Resultsmentioning

confidence: 99%

Physicochemical characterization of nanobidentate ferrocene‐based Schiff base ligand and its coordination complexes: Antimicrobial, anticancer, density functional theory, and molecular operating environment studies

Mahmoud

2019

J Chinese Chemical Soc

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A novel bidentate Schiff base ligand (HL, Nanobidentate Ferrocene based Schiff base ligand L (has one replaceable proton H)) was prepared via the condensation of 2‐amino phenol with 2‐acetyl ferrocene. The ligand was characterized using elemental analysis, mass spectrometry, infrared (IR) spectroscopy, 1proton nuclear magnetic resonance (H‐NMR) spectroscopy, scanning electron microscopy (SEM), and thermal analysis. The corresponding 1:1 metal complexes with some transition‐metal ions were additionally characterized by their elemental analysis, molar conductance, SEM, and thermogravimetric ana1ysis (TGA). The complexes had the general formula [M(L)(Cl)(H2O)3]xCl·nH2O (M = Cr(III), Mn(II), Fe(III), Co(II), Ni(II), Cu(II), Zn(II), and Cd(II)), (x = 0 for Mn(II), Co(II), Ni(II), Cu(II), Zn(II), and Cd(II), x = 1 for Cr(III) and Fe(III)), (n = 1 for Cr(III), n = 3 for Mn(II) and Co(II), n = 4 for Fe(III), Ni(II), Cu(II), Zn(II), and Cd(II)). Density functional theory calculations on the HL ligand were also carried out in order to clarify molecular structures by the B31YP exchange‐correlation function. The results were subjected to molecular orbital diagram, highest occupied mo1ecu1ar orbital–lowest occupied molecular orbital, and molecular electrostatic potential calculations. The parent Schiff base and its eight metal complexes were assayed against four bacterial species (two Gram‐negative and two‐Gram positive) and four different antifungal species. The HL ligand was docked using molecular operating environment 2008 with crystal structures of oxidoreductase (1CX2), protein phosphatase of the fungus Candida albicans (5JPE), Gram(−) bacteria Escherichia coli (3T88), Gram(+) bacteria Staphylococcus aureus (3Q8U), and an androgen‐independent receptor of prostate cancer (1GS4). In order to assess cytotoxic nature of the prepared HL ligand and its complexes, the compounds were screened against the Michigan cancer foundation (MCF)‐7 breast cancer cell line, and the IC50 values of compounds were calculated.

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Synthesis, spectroscopic, thermogravimetric and antimicrobial studies of mixed ligands complexes

Cited by 44 publications

References 49 publications

Thiazole derivatives‐functionalized polyvinyl chloride nanocomposites with photostability and antimicrobial properties

Thiazole derivatives‐functionalized polyvinyl chloride nanocomposites with photostability and antimicrobial properties

Ternary metal complexes of guaifenesin drug: Synthesis, spectroscopic characterization and in vitro anticancer activity of the metal complexes

Physicochemical characterization of nanobidentate ferrocene‐based Schiff base ligand and its coordination complexes: Antimicrobial, anticancer, density functional theory, and molecular operating environment studies

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