Synthesis, spectroscopic studies and inhibitory activity against bactria and fungi of acyclic and macrocyclic transition metal complexes containing a triamine coumarine Schiff base ligand

Mahmoud, Nelly H.; Linert, Wolfgang

doi:10.1016/j.saa.2015.01.063

Cited by 48 publications

(27 citation statements)

References 46 publications

(33 reference statements)

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“…The values for the chloride complexes indicate that both chlorides are coordinated to the metal. The elemental analyses are consistent with the proposed formulae, and that the ratio of M/L in all of these complexes is 1:1 [33,34].…”

Section: Molar Conductivitiessupporting

confidence: 83%

Synthesis and characterization of transition metal complexes of a hexadentate N4O2 donor Schiff base ligand: X-ray crystal structures of the copper(II) and zinc(II) complexes and their antibacterial properties

Keypour

Shooshtari

Rezaeivala

et al. 2015

Transition Met Chem

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A potentially hexadentate N 4 O 2 Schiff base ligand, L, has been synthesized by condensation of an aromatic diamine with 2-pyridinecarbaldehyde. The complexes [MLNO 3 ]NO 3 (M=Cu, Ni, Cd or Zn) and [MlCl 2 ] (M=Co or Mn) were synthesized by the reactions of L with metal salts in methanol. Both free L and its complexes were characterized by physicochemical and spectroscopic methods. In addition, the crystal structures of [CuLNO 3 ]-NO 3 and [ZnLNO 3 ]NO 3 have been determined by singlecrystal X-ray diffraction. In both complexes, the ligand L is coordinated via pyridine and azomethine nitrogen atoms to give a distorted octahedral geometry. These complexes have antibacterial activities against three Gram-positive and three Gram-negative bacteria, which in most cases exceed those of tobramycin and tetracycline as standards.

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Section: Molar Conductivitiessupporting

confidence: 83%

Synthesis and characterization of transition metal complexes of a hexadentate N4O2 donor Schiff base ligand: X-ray crystal structures of the copper(II) and zinc(II) complexes and their antibacterial properties

Keypour

Shooshtari

Rezaeivala

et al. 2015

Transition Met Chem

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“…This shift can be attributed to intramolecular hydrogen bonding. The coordinating water in the complexes is characterized by the appearance of two bands at 931–993 and 837–896 cm −1 …”

Section: Resultsmentioning

confidence: 99%

Novel Schiff base ligand and its metal complexes with some transition elements. Synthesis, spectroscopic, thermal analysis, antimicrobial and in vitro anticancer activity

Mahmoud

Deghadi

Mohamed

2016

Applied Organom Chemis

125

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A novel Schiff base ligand (H2L) was prepared through condensation of 2,6‐diaminopyridine and o‐benzoylbenzoic acid in a 1:2 ratio. This Schiff base ligand was characterized using elemental and spectroscopic analyses. A new series of Cr(III), Mn(II), Fe(III), Co(II), Ni(II), Cu(II), Zn(II) and Cd(II) metal complexes of H2L were prepared and characterized using elemental analysis, spectroscopy (1H NMR, mass, UV–visible, Fourier transform infrared, electron spin resonance), magnetic susceptibility, molar conductivity, X‐ray powder diffraction and thermal analysis. The complexes are found to have trigonal bipyramidal geometry except Cr(III), Mn(II) and Fe(III) complexes which have octahedral geometry based on magnetic moment and solid reflectance measurements. The infrared spectral studies reveal that H2L behaves as a neutral bidentate ligand and coordinates to the metal ions via the two azomethine nitrogens. 1H NMR spectra confirm the non‐involvement of the carboxylic COOH proton in complex formation. The presence of water molecules in all reported complexes is supported by thermogravimetric studies. Kinetic and thermodynamic parameters were determined using Coats–Redfern and Horowitz–Metzger equations. The synthesized ligand and its complexes were screened for antimicrobial activities against two Gram‐positive bacteria (Bacillus subtilis and Staphylococcus aureus), two Gram‐negative bacteria (Escherichia coli and Neisseria gonorrhoeae) and one fungus (Candida albicans). Anticancer activities of the ligand and its metal complexes against human breast cancer cell line (MCF7) were investigated. Copyright © 2016 John Wiley & Sons, Ltd.

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“…The present study is an extension to our research work for the formation of mono- and binuclear complexes for coumarin derivatives, synthesized by the condensation of 4-hydroxycoumarin with oxalyldihydrazide in the molar ratio of 1:2, to afford the corresponding hydrazine [22]. Mono- and binuclear complexes of Co(II), Ni(II), Cu(II), VO(IV), and Fe(III) with the hydrazone Schiff base ligand have been prepared.…”

Section: Introductionmentioning

confidence: 99%

Syntheses, characterization, and biological activity of novel mono- and binuclear transition metal complexes with a hydrazone Schiff base derived from a coumarin derivative and oxalyldihydrazine

2017

Self Cite

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A hydrazone Schiff base ligand was synthesized by the condensation of 3-formyl-4-hydroxycoumarin and oxalyldihydrazide in the molar ratio 2:1. The Schiff base ligand acts as a mono-, bi-, tri- or even tetradentate ligand with metal cations in the molar ratios 1:1 or 2:1 (M:L) to yield either mono- or binuclear complexes as keto or enol isomers, where M = Co(II), Ni(II), Cu(II), VO(IV), and Fe(III). The ligand and its metal complexes were characterized by elemental analyses, IR, 1H NMR, mass, and UV–Vis spectroscopy. Furthermore, the magnetic moments were calculated from the measured electric conductivities of the complexes. According to the received data, the dihydrazone ligand contains one or two units of ONO domains and can bind to the metal ions via the azomethine nitrogen, the carbonyl oxygen atoms, and/or the phenolic oxygen atoms. Electronic spectra and the magnetic moments of all complexes show that the complexes’ geometries are either octahedral, tetrahedral, square planar, or square pyramidal. Cyclic voltammograms of the mononuclear Co(II) and Ni(II) complexes show quasi-reversible peaks. Tests against two pathogenic bacteria as Gram-positive and Gram-negative bacteria for both, the Schiff base ligand and its metal complexes were carried out. In addition, also one kind of fungi was tested. The synthesized complexes demonstrate mild antibacterial and antifungal activities against these organisms.Graphical abstract Electronic supplementary materialThe online version of this article (doi:10.1007/s00706-017-2075-9) contains supplementary material, which is available to authorized users.

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Synthesis, spectroscopic studies and inhibitory activity against bactria and fungi of acyclic and macrocyclic transition metal complexes containing a triamine coumarine Schiff base ligand

Cited by 48 publications

References 46 publications

Synthesis and characterization of transition metal complexes of a hexadentate N4O2 donor Schiff base ligand: X-ray crystal structures of the copper(II) and zinc(II) complexes and their antibacterial properties

Synthesis and characterization of transition metal complexes of a hexadentate N4O2 donor Schiff base ligand: X-ray crystal structures of the copper(II) and zinc(II) complexes and their antibacterial properties

Novel Schiff base ligand and its metal complexes with some transition elements. Synthesis, spectroscopic, thermal analysis, antimicrobial and in vitro anticancer activity

Syntheses, characterization, and biological activity of novel mono- and binuclear transition metal complexes with a hydrazone Schiff base derived from a coumarin derivative and oxalyldihydrazine

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