Synthesis, spectroscopic, redox properties, and DNA cleavage activity of low-spin iron(III) complexes of bleomycin analogues

Ternary iron(ii) complex with an emissive imidazopyridine arm from Schiff base cyclizations and its oxidative DNA cleavage activity

“…[4][5][6][7][8] In contrast, synthetic model iron complexes are rare, possibly due to the structural complexity of BLMs. [9][10][11][12][13][14][15] Scheme 1 Schematic structure of Bleomycins.…”

28 Inorganic pharmaceuticals

“…78^81 This includes the in£uence of varying the metal centre stereochemistry, which has not been determined by X-ray crystallography, on DNA interactions and model iron complexes. 82,83 A new potential iron-pharmaceutical is promised by the non-covalent hydrophobic binding of synthetic iron porphyrin complexes bearing an imidazole side chain to human albumin. The complex reversibly binds dioxygen in the manner of haemoglobin and thus has the potential to be used as a non-toxic red-cell substitute for emergency transfusions.…”

Synthetic analogue approach to metallobleomycins: syntheses, structure and properties of mononuclear and tetranuclear gallium(III) complexes of a ligand that resembles the metal-binding site of bleomycin

“…These low molecular weight metal complexes are ideally obtainable in crystalline form and can provide structural and spectroscopic data that relate to the MBLM. Pioneer work from Mascharak [32][33][34][35][36][37][38][39][40][41][42][43][44][45][46][47] and others [48][49][50][51][52][53][54][55] on the ''synthetic analogue approach'' has provided substantial information about the structure and function of MBLMs described above.…”