28 Inorganic pharmaceuticals

Thermal behavior and other properties of Pr(III), Sm(III), Eu(III), Gd(III), Tb(III) complexes with 4,4′-bipyridine and trichloroacetates

“…This work is a continuation of our previous studies on synthesis, properties, and thermal decomposition of metal complexes with bipyridine isomers and carboxylates [1][2][3][4][5][6][7]. Lanthanide compounds are curious for many research workers in last years because of their variety applications [8][9][10][11][12][13]. Halogenoacetates complexes show varied types of coordination, therefore they are interesting ligands.…”

30 Inorganic pharmaceuticals

“…Several peptides and proteins for selective delivery have been reported, including the somatostatin analogue octreotide, 51,52 collagen fragments, 53 and antibodies. 54, 55 These agents were conjugated to the copper radionuclide via bifunctional chelators incorporating tetaH 4 (1,4,8,11-tetraazacyclotetradecane-N,NЈ,NЉ,Nٞ-tetraacetic acid) 51,53 and dotaH 4 (1,4,7,10-tetraazacyclododecane-N,NЈ,NЉ,Nٞ-tetraacetic acid). 52, 55 Further developments in the design of bifunctional chelators for these applications have also been reported.…”

“…The definition of inorganic pharmaceuticals for the purposes of this report is as previously indicated. 1 In addition to developments classified below (in order of increasing atomic number of the element concerned), a number of useful general reviews not cited in specific sections below have appeared. These cover metal complexes of anti-inflammatory drugs, 2 catalysis of DNA hydrolysis by lanthanides 3 and other metals, 4 platinum binding to DNA, 5 imaging and therapy uses of peptide conjugates of radioactive metals, 6,7 and general aspects of chelator design for these applications.…”

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“…For definitions of what comprises 'inorganic pharmaceuticals', the reader is referred to ref. 1. 1 The dominant areas are again platinum anti-cancer drugs and radiopharmaceuticals, with the use of therapeutic radiopharmaceuticals gaining further momentum.…”