Synthesis, Spectroscopic Characterization and in Vitro Cytotoxicity Assay of Mropholine Mannich Base Derivatives of Benzimidazole with Some Heavy Metals

Alias, M. F. A.; Bakir, Shaimaa R.

doi:10.22401/jnus.21.3.06

Cited by 4 publications

(4 citation statements)

References 5 publications

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“…This shift indicates the coordination occurrence through the imine group, nitrogen ring of the thiadiazole, and S as tridentate ligand (17). The spectra of all the complexes show the additional medium intensity bands in the range 519-470, 470-412, and 369-320 cm -1 assigned to the υ(M-N), υ(M-S), and υ(M-Cl), respectively (18,21). Other bands of the coordinated water and others to water outside the coordinated sphere can be observed in Table 3.…”

Section: Fourier Transforms Spectroscopy (Ft-ir) Of Ligand and Their ...mentioning

confidence: 91%

“…The bands in the region 22935, 25250 and 37038, 47393 cm -1 is due to n → π* transition of the non-bonding electrons present on S, N, and to π → π* of aromatic ring in the ligand [18]. The magnetic measurement of brown complex CoL (3.92) B.M indicates that to be paramagnatic and high spin octahedral [19].…”

Section: Uv-vis Spectra Magnetic Susceptibility and Molar Conductivitymentioning

confidence: 99%

“…The FT-IR spectrum for free ligand showed five major bands 1620 cm -1 , 1581 cm -1 , 1222 cm -1 , 740 cm -1 , and 2893, 2903 cm -1 , returned to ν CH=Nschiff (24), νC=Ncyclic of thiadiazole (24), νCSC (18), ν CS (21), and ν (CH2-N) (25), respectively. Some of these peaks are shifted towards the high or low frequencies when they are coordinated with the metal ions.…”

Section: Fourier Transforms Spectroscopy (Ft-ir) Of Ligand and Their ...mentioning

confidence: 99%

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2023

J. Med. Chem. Sci.

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The Schiff-Mannich base was derived from 1,3,4 thiadazole prepared by combining of 2-amino-5-mercapto-1,3,4 thiadazole and 4-N,N-dimethyl benzaldehyde with indol. The result compound was 5-((1 H-ind ol -1-yl) methylthio)-N-(4-(dimethylamino)benzylidene)-,1,3,4-thiadiazol-2-amine(L), coordinated with six metal ion Co(II), Ni(II), Cu(II), Pd(II), Pt(IV), and Au(III). The ligand (L) has been characterized by using the following techniques, C.H.N.S, FT-IR, UV-ViS, 1 H-NMR, and 13 C-NMR. In addition, the measurement of (atomic absorption spectra, magentic susceptibility, and molar conductivity) was used when diagnosing the complexes. The experimental results showed that the ligands coordinated as tri-dentate with metal ions. The antibacterial and antifungal activity of all complexes were studied against Staphylococcus aureus and Bacillus subtilis as a model of gram-positive, as well as E-coli and Klebsiella pneumoniae as a gram-negative at a concentration of 0.02 M. Likewise, the effectiveness of the prepared compounds was determined in inhibiting selected types of bacteria and fungi. The results showed that the prepared metal complexes and ligand are more effective than the standard drug in bacteria and fungi. The metal to ligands ratio was determined by the molar ratio method and showed the metal interaction with the ligand proportion (1:1). Also, the compounds prepared were studied in gas phase by using the hyper-chem8.0.7 program. Through this program, the heat of formation, binding energy, HOMO and LUMO, and the electrostatic potential in addition to the infrared vibration of the ligand were calculated.

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Section: Fourier Transforms Spectroscopy (Ft-ir) Of Ligand and Their ...mentioning

confidence: 91%

Section: Uv-vis Spectra Magnetic Susceptibility and Molar Conductivitymentioning

confidence: 99%

Section: Fourier Transforms Spectroscopy (Ft-ir) Of Ligand and Their ...mentioning

confidence: 99%

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2023

J. Med. Chem. Sci.

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“…A new series of mannich base morpholine derivatives of benzimidazole (10) were studied for their in vitro cytotoxicity and these novel designed products were screened for their in vitro cytotoxic potential against RAW 264.7 cell lines and some of them showed remarkable anticancer activity. Presence of morphline moiety in compound and presence of imidazole group in compound declared them as potent anticancer agents (18).…”

Section: Anticancer Activitymentioning

confidence: 99%

General Aspects, Applications, and Recent Advancements of 1, 2-Disubstituted Benzimidazole Mannich Bases: A Privileged Scaffold

Babbar¹,

Arora²

2022

ECS Trans.

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Chemistry of heterocyclic compounds performs foremost part in synthesis of various pharmacological active compounds. Existence of benzimidazole core in innumerable group of medicinal agents, such as anti-inflammatory, anticancer, antiviral, antimicrobial, antihypertensive, and immune-modulators, contributed them to be essential announcer for growth of new pharmacological active agents. Mannich synthesis is significantly used in organic chemistry. This reaction is useful for synthesizing many bioactive drug molecules. The survey of literature notifies the fact about these bases that are extremely energetic and acknowledge to constitute dominant actions like anti-tumor, antibacterial, anthelmintic, anti-psychotic, anti-malarial, anti-tubercular, anti-viral activities, and many more.

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In Vitro Cytotoxicity Study of Pt Nanoparticles Decorated TiO2 Nanotube Array

et al. 2020

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Titanium dioxide nanotubes were synthesized by anodizing Ti sheets in the ethylene glycol solution and were covered in Pt nanoparticles onto the surface of TiO2NTs using electrodeposition method from using five derivatives of Mannich base Pt complexes which have been used as precursor of platinum. The mean size, shape, elemental composition of the titanium dioxide nanotubes and platinum deposited on the template were evaluated by different techniques such as field emission scanning electron microscope (FE-SEM), transmission electron microscopy (TEM), X-ray diffraction pattern (XRD), and energy dispersive X-ray (EDX) technique. From all these analyses, the TiO2NTs prepared and Ptnanoparticles deposited on it were identified. The diagnoses proved that all the Pt nanoparticles have a size less than 50 nm. The MCF-7 cancer cell lines and WRL68 normal cell lines were treated with concentration 800, 400,200,100, 50, 25, 12.5µg\ml of TiO2NTs and Pt\TiO2NTs(1) and (2) for 48hours using MTT assay.IC50 and inhibition rate were calculated. The result shows that the Pt\TiO2NTs have more inhibition effect on cancer cell lines than TiO2NTs array.

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Synthesis, Spectroscopic Characterization and in Vitro Cytotoxicity Assay of Mropholine Mannich Base Derivatives of Benzimidazole with Some Heavy Metals

Cited by 4 publications

References 5 publications

Untitled

Untitled

General Aspects, Applications, and Recent Advancements of 1, 2-Disubstituted Benzimidazole Mannich Bases: A Privileged Scaffold

In Vitro Cytotoxicity Study of Pt Nanoparticles Decorated TiO2 Nanotube Array

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