Synthesis, Spectroscopic and Thermal Characterization of Copper(II) and Iron(III) Complexes of Folic Acid and Their Absorption Efficiency in the Blood

Abstract

The absorption efficiency of any drug in blood is of prime importance. Compounds having the general formula: Kn[M(FO)2(H2O)2] · xH2O, where (M = Cu(II) or Fe(III), n = 2 or 1, FO = folate anion, x = 2 or 3 with respect), were prepared, and their absorption efficiency in rodent's blood was determined. The obtained compounds were characterized by elemental analysis, infrared as well as thermogravimetric analysis and polarization of light. The results suggest that the two folate complexes were formed in 1 : 2 molar ratio (metal : folic acid) which acted as a bidentate ligand through both carboxylic groups. Polarization of light proved that the folate complexes have symmetric geometry. Biological application proved that Cu(II) and Fe(III) complexes were absorbed more efficiently in rodent blood than folic acid itself.

The synthesis and characterisation of strontium and calcium folates with potential osteogenic activity

“…This behaviour is in concordance with folic acid thermal stability and other folate-metal complexes described by different authors and reveals the formation of proposed compounds. [13][14][15][16] Coordination between the carboxylic group of the folate derivatives and the different cations have been described in the literature indicating the possibility of chelating mode through monodentate or bidentate bridging as shown in Fig. 4.…”

Highly Selective Optical Sensor Eu (TTA)3 Phen Embedded in Poly Methylmethacrylate for Assessment of Total Prostate Specific Antigen Tumor Marker in Male Serum Suffering Prostate Diseases

“…The sensitivity of the optical sensor toward the tPSA depends on the ratio between the two emission bands at 590 nm (magnetic-dipole), where the 5 D 0 → 7 F 1 transition is not affected by the coordinate environment, and 614 nm (electric dipole), in which the transition 5 D 0 → 7 F 2 is the most intense peak, suggesting that Eu (III) occupies an inversion centered site. Any variation in the surrounding chemical environment of the sensor affects the electric dipole band (Hamed et al, 2009) of the Eu (III).…”

Interaction of folic acid and some matrix metalloproteinase (MMP) inhibitor folate-γ-hydroxamate derivatives with Zn(II) and human serum albumin

“…Literature data on the binding modes of complexes formed between folic acid and divalent transition metal ions show that the ligand can coordinate via the pteridinic (O ,N (5) ) or mainly via the (O ,N (5) ,N (10) ) donor sets [24,[52][53][54] as it is depicted in Scheme 3, but data are rather contradictory for coordination via glutamate carboxylates [55,56].…”