Synthesis, spectroscopic and structural aspects of some tetraorganodistannoxanes with internally functionalized oxime: crystal and molecular structures of [{R2Sn(ONC(Me)py)}2O]2 (R=Bun and Et) and 2-NC5H4C(Me)NOH

Sharma, Vinita; Sharma, Ramavtar; Bohra, Rakesh; Ratnani, Raju; Jain, Vimal K.; Drake, John E.; Hursthouse, Michael B.; Light, Mark E.

doi:10.1016/s0022-328x(02)01330-x

Cited by 43 publications

(25 citation statements)

References 49 publications

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“…Oximes, including internally functionallized oximes, constitute an important class of N/O type donor ligands [34][35][36][37][38][39] because of their varying coordination abilities with the metal centers. Our previous studies on oximato complexes with some main group and transition metals show quite interesting structural features in both the solution and solid states [40][41][42][43][44][45][46][47]. The distinctive preference of the vanadium ion for these types of ligands has further promoted the synthesis and characterization of many model complexes containing N/O donor ligands [2,3,6,12,25,33,48,49].…”

Section: Introductionmentioning

confidence: 99%

Synthesis and characterization of some oxovanadium(V) complexes with internally functionallized oximes. Crystal and molecular structure of heptacoordinated [VOCl{ON=C(CH3) (C4H3S-2)}2] · CH3OH

Sharma

Bohra

et al. 2007

Transition Met Chem

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New heteroleptic oxovanadium(V) chloro oximato complexes of the type [VO{Cl} 3-n {ON=C(CH 3 )(Ar)} n ] (where Ar = C 4 H 3 O-2, C 4 H 3 S-2, C 5 H 4 N-2 and n = 1 or 2) have been synthesized in excellent yields by the reaction of VOCl 3 with the sodium salts of corresponding internally functionallized oximes in refluxing anhydrous benzene. The complexes are characterized by elemental analyses and spectroscopic techniques (FT-IR, 1 H-, 1 3C{ 1 H}-and 51 V-NMR). FAB mass spectral analysis of one of the derivatives, [VOCl{ON=C(CH 3 )C 4 H 3 S} 2 ] indicates the monomeric nature of the complex. 51 V-NMR spectral studies of these complexes suggest tetra-coordination around the vanadium atom in solution. However, the single crystal X-ray diffraction study of a redistribution product [VOCl{ON=C(CH 3 )(C 4 H 3 S-2)} 2 ] AE CH 3 OH obtained on recrystallization of [VOCl 2 {ON=C(CH 3 )(C 4 H 3 S-2)}] from a methanol-hexane mixture shows the vanadium(V) atom is hepta-coordinated with distorted pentagonal bipyramidal geometry. The oxo-atom occupies the axial position while the weakly coordinated CH 3 OH group is trans to the V=O atom. The two oximato ligands in the approximate pentagonal plane are bonded to the central vanadium atom in dihapto (g 2 -N, O) manner with the formation of three-membered rings. The V-Cl bond occupies the fifth position in the approximate plane.

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Section: Introductionmentioning

confidence: 99%

Synthesis and characterization of some oxovanadium(V) complexes with internally functionallized oximes. Crystal and molecular structure of heptacoordinated [VOCl{ON=C(CH3) (C4H3S-2)}2] · CH3OH

Sharma

Bohra

et al. 2007

Transition Met Chem

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“…5) Presently, the biological activity of organotin compounds is well known owing to their practical applications as fungicides, bactericides, biocides, and pesticides. 4,[6][7][8] However, one of the fields that have been more studied and reviewed is the activity of such compounds against cancer. 2,4,9,10) Up to date several articles concerning antitumor activity of organometallic tin-containing compounds have been reported.…”

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Synthesis, Characterization and in Vitro Cytotoxicity of Pentacoordinated Tin(IV) Complexes Derived from Aminoalcohols

Gómez¹,

Contreras‐Ordoñez²,

Ramírez‐Ápan³

2006

CHEMICAL & PHARMACEUTICAL BULLETIN

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The synthesis of pentacoordinated Tin(IV) compounds derived from aminoalcohols is described. The compounds were characterized by IR, 1 H-, 13C-, and 119Sn-NMR, the mass spectrometry exhibits molecular ions corresponding to monomeric species. All compounds were evaluated for in vitro cytotoxic activities against five human tumor cell lines, U251 (human glioblastoma), PC-3 (human prostatic adenocarcinoma), K-562 (human chronic myelogenous leukemia), HCT-15 (human colorectal adenocarcinoma), MCF-7 (human mammary adenocarcinoma). The cytotoxic evaluation revealed that all compounds possess higher cytotoxic potency than that of the cisplatin, which was used as reference. Additionally, MT2 cells (human T-lymphocytes) were also evaluated.

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“…The biological activity of organotin compounds has become well known due to their practical applications as fungicides, bactericides, biocides, and pesticides [3,[6][7][8]. It is now well established that organotin compounds are very important in cancer chemotherapy [9] and as potential anti-cancer agents [10][11][12][13].…”

Section: Introductionmentioning

confidence: 99%

“…In addition, the organometallic-DNA and organometallic-nucleic acid interactions of these compounds have also been investigated [2][3][4]. More recently, ferricenium salts, organotin, and bismuth complexes have also emerged as examples of organometallic compounds that have been found to exhibit interesting anti-tumour activity [5].The biological activity of organotin compounds has become well known due to their practical applications as fungicides, bactericides, biocides, and pesticides [3,[6][7][8]. It is now well established that organotin compounds are very important in cancer chemotherapy [9] and as potential anti-cancer agents [10][11][12][13].…”

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An in vitro study on the effect of synthesized tin(IV) complexes on glioblastoma, colorectal, and skin cancer cell lines

Williams¹,

Lewis-Alleyne²,

Solomon³

et al. 2016

Biomed Res Clin Prac

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Abstract((E)-2-(2-hydroxybenzylideneamino)phenolato-2,2-diphenyl-6-aza-1,3-dioxa-2-stanna- [d,h] dibenzocyclononene, [Sn(Ph 2 SB)] (compound 1, where Ph 2 SB=(E)-2-(2-hydroxybenzylideneamino)phenolato Schiff base) and two novel compounds, [[SnPh 2 (F-azoSB)] (compound 2, where F-azoSB=4-((E)-(4-fluorophenyl) diazenyl)-2-((E)-(2-hydroxyphenylimino)methyl)phenolato Schiff base), [[SnPh 2 (sulf-azoSB)]0.125CHCl 3 (compound 3, where sulfamerazineazosalSB=4-((E)-(4-hydroxy-3-((E)-(2-hydroxyphenylimino)methyl)phenyl)diazenyl)-N-(4-methylpyrimidin-2-yl) benzenesulfonamide Schiff base), and the control compound, cisplatin (compound 4) were analysed to comparatively determine their effect on cancer cell growth. Anti-cancer properties of compounds 1-4 were examined using glioblastoma (U-1242 MG), colorectal (HT-29 and HCT-116), and skin (A431) human cancer cell lines. With regards to human glioblastoma cells, compounds 1 and 3 demonstrated anti-proliferative capacity in the cell line tested. Specifically, compounds 1 and 3 inhibited cell proliferation by 50% at concentrations between 10 and 50 µM. With respect to colon cancer cell lines, the IC 50 values for compounds 1-3 ranged from 3.04 ± 0.98 to 104.51 ± 13.87 µM. In the case of HCT-116, this translates to a 3-to 73-fold inhibitory effect of compounds 1-3 over cisplatin. In all cell lines tested, the chemo-effect was more pronounced with compounds 1-3 than with the control (compound 4); demonstrating that these azo-containing Sn(IV) complexes were more potent than compound 4. The overall effect of compounds 1-3 in the induction of appotosis and the inhibition of proliferation have defined an essential role for these compounds in chemotherapy. IntroductionFrom the late 1960s until the present, there have been significant advances in both the early detection and the treatments of cancer. Despite these advances overall incidences of cancer and deaths from cancer have increased during the same period [1]. These counterintuitive increases have been the impetus for development of new drugs for cancer treatment. In this context the organometallic compounds have been widely investigated as potential anti-tumour agents. Metallocene dihalide complexes Cp 2 MX 2 (where M=titanium, vanadium, niobium, or molybdenum) were the first early transition metal complexes that were shown to have anti-tumour activity. In addition, the organometallic-DNA and organometallic-nucleic acid interactions of these compounds have also been investigated [2][3][4]. More recently, ferricenium salts, organotin, and bismuth complexes have also emerged as examples of organometallic compounds that have been found to exhibit interesting anti-tumour activity [5].The biological activity of organotin compounds has become well known due to their practical applications as fungicides, bactericides, biocides, and pesticides [3,[6][7][8]. It is now well established that organotin compounds are very important in cancer chemotherapy [9] and as potential anti-cancer agents [10][11][12][13]. This is due in part to thei...

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Synthesis, spectroscopic and structural aspects of some tetraorganodistannoxanes with internally functionalized oxime: crystal and molecular structures of [{R2Sn(ONC(Me)py)}2O]2 (R=Bun and Et) and 2-NC5H4C(Me)NOH

Cited by 43 publications

References 49 publications

Synthesis and characterization of some oxovanadium(V) complexes with internally functionallized oximes. Crystal and molecular structure of heptacoordinated [VOCl{ON=C(CH3) (C4H3S-2)}2] · CH3OH

Synthesis and characterization of some oxovanadium(V) complexes with internally functionallized oximes. Crystal and molecular structure of heptacoordinated [VOCl{ON=C(CH3) (C4H3S-2)}2] · CH3OH

Synthesis, Characterization and in Vitro Cytotoxicity of Pentacoordinated Tin(IV) Complexes Derived from Aminoalcohols

An in vitro study on the effect of synthesized tin(IV) complexes on glioblastoma, colorectal, and skin cancer cell lines

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