The synthesis of pentacoordinated Tin(IV) compounds derived from aminoalcohols is described. The compounds were characterized by IR, 1 H-,
13C-, and
119Sn-NMR, the mass spectrometry exhibits molecular ions corresponding to monomeric species. All compounds were evaluated for in vitro cytotoxic activities against five human tumor cell lines, U251 (human glioblastoma), PC-3 (human prostatic adenocarcinoma), K-562 (human chronic myelogenous leukemia), HCT-15 (human colorectal adenocarcinoma), MCF-7 (human mammary adenocarcinoma). The cytotoxic evaluation revealed that all compounds possess higher cytotoxic potency than that of the cisplatin, which was used as reference. Additionally, MT2 cells (human T-lymphocytes) were also evaluated.
Ring opening reactions O 0132 Facile Synthesis of Aminoalcohols by Ring Opening of Epoxides under Solvent-Free Conditions. -The cleavage of symmetrical and unsymmetrical epoxides under solvent-free conditions using aromatic and aliphatic amines offers a convenient entry to β-amino alcohols. -(HUERTA, G.; CONTRERAS-ORDONEZ, G.; ALVAREZ-TOLEDANO, C.; SANTES, V.; GOMEZ*, E.; TOSCANO, R. A.; Synth.
Abstract. The preparation and structural characterization of dimeric and monomeric siloxanes are described. The silicon complexes were obtained from β-amino alcohols and dichlorodimethylsilane, bisdimethylaminodimethylsilane and diphenyldichlorosilane. The complexes were characterized by 1H, 13C and 29Si NMR spectroscopy and mass spectrometry. The X-ray crystallography study for one compound confirmed the formation of a sixteen-membered heterocycle.Resumen. En este trabajo se describe la preparación y la caracterización de siloxanos diméricos y monoméricos. Los complejos de silicio se obtuvieron por reacción de β-amino alcoholes con diclorodimetilsilano, bisdimetilaminodimetilsilano y diclorodifenilsilano. Los complejos se caracterizaron por RMN de 1H, 13C y 29Si, y espectrometría de masas. La estructura molecular de un anillo de 16 miembros para uno de los compuestos se confirmó por difracción de rayos-X.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.