Synthesis, spectral characterization, thermal, computational and antibacterial studies of lanthanide complexes with 2-fluorobenzoic acid-(5-R-2-hydroxy-benzylidene)hydrazide {R = chloro or bromo)

Taha, Ziyad A.; Ababneh, Taher S.; Hijazi, Ahmed K.; AL-Aqtash, Sajeda M.; Momani, Waleed; Mhaidat, Ibrahim

doi:10.1016/j.jscs.2021.101400

Cited by 2 publications

(1 citation statement)

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“…[ 42–44 ] Additional band appears at 1068 cm −1 , due to ν(N–NH). [ 45,46 ] Meanwhile, the stretching vibrations of aromatic −CH and −CH 2 bands are observed at 3050 and 2982, 2920 cm −1 , respectively. [ 37,47 ] The ligand spectrum reveals a medium characteristic band at 1446 cm −1 , attributed to −CH 2 deformation [ 44,48 ] (Table 2).…”

Section: Resultsmentioning

confidence: 99%

Spectral studies, thermal investigations, and anticancer activity of some divalent metal complexes derived from 2‐(4‐bromophenylamino)acetohydrazide ligand

Emara

El‐Sayed

Khalaf‐Allah

et al. 2022

Applied Organom Chemis

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A series of biologically active metal complexes was yielded from the reactions of 2‐(4‐bromophenylamino)acetohydrazide ligand (HL) with Co(II), Ni(II), Cu(II), Cd(II) chlorides, CuBr2, Cu(CH3COO)2, and Cu(ClO4)2 salts. The structure and stereochemistry of the afforded complexes were elucidated by means of elemental analyses, molar conductance, magnetic susceptibility, thermal analyses (TG/DTG), and spectral techniques (mass, IR, UV‐Vis, and 1H NMR). Elemental analyses along with molar conductance data demonstrated that all metal complexes are nonelectrolyte and were formed with 1L:1M, 1L:2M, and 2L:1M stoichiometry. IR spectral data provided an evidence for the neutral bidentate behavior of the hydrazide ligand toward metal ions via carbonyl oxygen and amino nitrogen atoms (ON donor). Magnetic susceptibility along with electronic absorption spectral results authenticated that all complexes have an octahedral geometry except, CuCl2 complex (3), which possessed a square planar one. The hydrazide ligand and some of its synthesized metal complexes were screened in vitro for their antitumor and apoptotic activity. The results showed that CuBr2 complex (4) has promising anticancer activities against breast MCF7, liver HepG2, and colorectal HCT 116 cancerous cells through induction of proapoptotic gene (Bax) and inhibit the antiapoptotic gene (Bcl‐2), thus increase the Bax/Bcl‐2 ratio. Moreover, these newly synthesized compounds were most potent and can be used as a therapeutic chemoprevention against these cancerous cells compared with doxorubicin (DOX), the currently available anticancer drug against solid tumors.

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