Synthesis, Spectral Characterization, Magnetic Moment, Mass, X-Ray Diffraction, and Kinetic (TGA) Studies of Cr(III) Complex with Metformin: An Oral Antidiabetic Drug

Abstract

The present work describes synthesis, spectral characterization, and X-ray diffraction studies of Cr(III) with “metformin,” an oral antidiabetic drug. The conductometric titration using monovariation method indicates that complex is ionic and of L2M type. Analytical data agree with the molecular formula of complex namely, [(C4H11N5)2Cr(H2O)2]2Cl. Geometry of complex assigned is octahedral, supported by IR, electronic spectra, magnetic moments,1H-NMR and mass studies, and proposed structure (I) for complex. X-ray diffraction data also supports the complex formation and symmetry of complex and various parameters like particle size, porosity, volume of unit cell, and density have been calculated. The Freeman-Carroll and Sharp-Wentworth methods have been used to calculate activation energy and thermal stability. The activation energy(Ea)calculated with the help of these methods are in agreement with each other. Thermodynamic parameters such as free energy change (ΔF) and entropy change are also determined on the basis of TG curves and by using data of the Freeman-Carroll method.

Synthesis, Spectral Characterization and Kinetic Study of Cu(II) Complex with N-Hexahydrocyclopenta[c]pyrrol-2(1H)-yl carbamoyl-4-methylbenzenesulfonamide

“…The first few points that did not fall on straight line were discarded. These types of deviations of points are reported in literature by several research workers [20][21][22][23][24][25][26][27][28][29] .…”

Antibacterial, DFT and molecular docking studies of metformin complex as active material for the fabrication of copper (II) selective potentiometric sensor

“…The solid complex of Cu (II) with metformin drug was synthesized by mixing 1.7 g of Cu (II) with 3.3 g of metformin drug in least amount of methanol with continuous stirring for about 2 hr at room temperature until complex was developed and the solutions were allowed to evaporate slowly at room temperature . The formed complex was filtered of, washed several times with little amounts of solvent and dried under vacuum over anhydrous calcium chloride.…”

Synthesis, Characterization and DFT Theoretical Studies of Metformin With Glycine Mixed Ligand and Their Complexes With Uranyl Ions

“…It was discovered that the platinum (IV) complex exhibits anticancer activity, while the vanadyl complex with metformin exhibits potential synergistic insulin mimics (Shahabadi and Heidari, 2012). Looking at the significance of metformin, the other metformin complexes, such as complexation with chromium, are thought to be the most commonly prescribed antidiabetic medication worldwide (Krishan et al, 2012). Additionally, studies of metformin complexes such as Co (II), Zn (II), and Pt (II) complexes have interesting thermal behavior in addition to having an antibacterial activity (Viossat, et al, 1995 ;Lemoine, et al,1996 ;Zhu, et al, 2002a andOlar, et al, 2005. The metformin ligand's metal complexes are typically cationic, and its brightly coloured chelate changes depending on the type of metal ion, its oxidation state, the number of ligands present in the complex, and these factors together In this study, metformin uranyl complexes were synthesized and characterized, and the structures of complexes will be investigated using several techniques.…”